(4-HYDROXYMETHYL-BENZYL)-CARBAMIC ACID TERT-BUTYL ESTER

Product Name: (4-HYDROXYMETHYL-BENZYL)-CARBAMIC ACID TERT-BUTYL ESTER
CAS No.: 123986-64-1
Chemical Name: (4-HYDROXYMETHYL-BENZYL)-CARBAMIC ACID TERT-BUTYL ESTER
Synonyms: 4-(BOC-AMINOMETHYL-PHENYL)-METHANOL;4-(N-Boc-aMinoMethyl)benzyl alcohol;N-Boc-4-(aminomethyl)benzyl Alcohol;tert-BUTYL-4-(HYDROXYMETHYL)BENZYLCARBAMATE;4-(Aminomethyl)benzyl alcohol, N-BOC protected;4-(Aminomethyl)benzylalcohol,N-BOCprotected97%;4-(tert-Butoxycarbonylaminomethyl)benzyl alcohol;tert-Butyl [4-(hydroxymethyl)benzyl]carbamate 97%;4-(N-TERT-BUTOXYCARBONYLAMINOMETHYL)BENZYL ALCOHOL;4-(Aminomethyl)benzyl alcohol, N-BOC protected 97%
CBNumber: CB6682736
Molecular Formula: C13H19NO3
Formula Weight: 237.29
MOL File: 123986-64-1.mol

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(4-HYDROXYMETHYL-BENZYL)-CARBAMIC ACID TERT-BUTYL ESTER Property

Melting point:: 98 °C
Boiling point:: 397.2±30.0 °C(Predicted)
Density: 1.106±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
form: solid
pka: 12.19±0.46(Predicted)
color: White

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Safety

Hazard Codes: Xi
Hazard Note: Irritant
HS Code: 2906290090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: H972423
Product name: (4-Hydroxymethyl-benzyl)-carbamicacidtert-butylester
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: H972423
Product name: (4-Hydroxymethyl-benzyl)-carbamicacidtert-butylester
Packaging: 500mg
Price: $65
Updated: 2021/12/16

BroadPharm

Product number: BP-21247
Product name: (4-HYDROXYMETHYL-BENZYL)-CARBAMICACIDTERT-BUTYLESTER
Packaging: 1g
Price: $70
Updated: 2021/12/16

AK Scientific

Product number: J92615
Product name: tert-Butyl4-(hydroxymethyl)benzylcarbamate
Packaging: 5g
Price: $75
Updated: 2021/12/16

Apolloscientific

Product number: OR14352
Product name: 4-(Aminomethyl)benzylalcohol,N-BOCprotected
Purity: 97%
Packaging: 5g
Price: $90
Updated: 2021/12/16

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(4-HYDROXYMETHYL-BENZYL)-CARBAMIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production

Synthesis

24424-99-5

39895-56-2

123986-64-1

GENERAL STEPS: A mixture of 4-(aminomethyl)benzenemethanol (1 g, 7.29 mmol) and di-tert-butyl dicarbonate (1.59 g, 7.29 mmol) in dichloromethane (30 mL) was reacted at room temperature with stirring overnight. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography with the eluent being a solvent mixture of dichloromethane and ethyl acetate (1:1, v/v) to afford tert-butyl 4-(hydroxymethyl)benzylcarbamate (0.8 g, 2.28 mmol, 31% yield) as a white solid. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 7.37 (s, 1H), 7.22 (dd, J = 27.8, 8.0 Hz, 4H), 5.13 (t, J = 5.7 Hz, 1H), 4.46 (d, J = 5.7 Hz, 2H), 4.10 (d, J = 6.1 Hz, 2H), 1.36 (s, 9H ).

References

[1] Patent: WO2006/12135, 2006, A1. Location in patent: Page/Page column 49-51
[2] Patent: US2006/293379, 2006, A1. Location in patent: Page/Page column 63
[3] Angewandte Chemie - International Edition, 2012, vol. 51, # 4, p. 941 - 944
[4] Chemical Communications, 2010, vol. 46, # 7, p. 1073 - 1075
[5] Journal of Medicinal Chemistry, 2009, vol. 52, # 1, p. 33 - 47

(4-HYDROXYMETHYL-BENZYL)-CARBAMIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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(4-HYDROXYMETHYL-BENZYL)-CARBAMIC ACID TERT-BUTYL ESTER Suppliers

Belgium 1 China 81 Germany 1 India 1 United Kingdom 3 United States 13 Global 100

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123986-64-1, (4-HYDROXYMETHYL-BENZYL)-CARBAMIC ACID TERT-BUTYL ESTERRelated Search:

Benzyl alcohol tert-butyl N-{[4-(dimethylphosphoryl)phenyl]methyl}carbamate Carbamic acid, N-[[(1R,2S)-2-aminocyclopentyl]methyl]-, 1,1-dimethylethyl ester tert-butyl N-{[1-(3-hydroxyazetidin-3-yl)cyclopropyl]methyl}carbamate tert-butyl N-[5-(prop-2-yn-1-yloxy)pentyl]carbamate 2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLIC ACID 2-TERT-BUTYL 6-METHYL 3,4-DIHYDROISOQUINOLINE-2,6(1H)-DICARBOXYLATE 4-[(tert-Butoxycarbonylamino)methyl]benzoic acid (3-HYDROXYMETHYL-BENZYL)-CARBAMIC ACID TERT-BUTYL ESTER 4-[(TERT-BUTOXYCARBONYL-METHYL-AMINO)-METHYL]-BENZOIC ACID METHYL ESTER 4-(BOC-AMIDINO)-BENZOIC ACID 2-(4-CARBOXY-PHENYL)-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 2-(TERT-BUTOXYCARBONYL)ISOINDOLINE-5-CARBOXYLIC ACID 4-(T-BOC-AMINOMETHYL)-3-CHLOROBENZOIC ACID (4-HYDROXYMETHYL-BENZYL)-CARBAMIC ACID TERT-BUTYL ESTER 4-(1-(TERT-BUTOXYCARBONYL)PIPERIDIN-2-YL)BENZOIC ACID tert-butyl 6-(1-hydroxy-1-methylethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate RARECHEM AL BO 1195

4-(BOC-AMINOMETHYL-PHENYL)-METHANOL

(4-HYDROXYMETHYL-BENZYL)-CARBAMIC ACID TERT-BUTYL ESTER

4-(N-TERT-BUTOXYCARBONYLAMINOMETHYL)BENZYL ALCOHOL

N-Boc-4-(aminomethyl)benzyl Alcohol

tert-butyl N-[[4-(hydroxymethyl)phenyl]methyl]carbamate

4-(N-tert-Butoxycarbonylaminomethyl)benzyl alcohol 97%

tert-BUTYL-4-(HYDROXYMETHYL)BENZYLCARBAMATE

(4-hydroxymethyl-benzyl)-carbamic acid ter-butyl ester

tert-Butyl [4-(hydroxymethyl)benzyl]carbamate 97%

4-(Aminomethyl)benzyl alcohol, N-BOC protected

4-(N-Boc-aMinoMethyl)benzyl alcohol

4-(Aminomethyl)benzyl alcohol, N-BOC protected 97%

tert-Butyl [4-(hydroxymethyl)benzyl]carbamate, 4-(Hydroxymethyl)benzylamine, N-BOC protected

4-[N-(tert-butoxycarbonyl)aminomethyl]-1-phenylmethanol

4-(Aminomethyl)benzylalcohol,N-BOCprotected97%

4-(tert-Butoxycarbonylaminomethyl)benzyl alcohol

Carbamic acid, N-[[4-(hydroxymethyl)phenyl]methyl]-, 1,1-dimethylethyl ester

1,1-Dimethylethyl N-[[4-(hydroxymethyl)phenyl]methyl]carbamate

123986-64-1

Phenyls & Phenyl-Het

Miscellaneous Biochemicals

Aminomethyl's

Phenyls & Phenyl-Het