ChemicalBook > CAS DataBase List > (4-HYDROXYMETHYL-BENZYL)-CARBAMIC ACID TERT-BUTYL ESTER

(4-HYDROXYMETHYL-BENZYL)-CARBAMIC ACID TERT-BUTYL ESTER

Product Name
(4-HYDROXYMETHYL-BENZYL)-CARBAMIC ACID TERT-BUTYL ESTER
CAS No.
123986-64-1
Chemical Name
(4-HYDROXYMETHYL-BENZYL)-CARBAMIC ACID TERT-BUTYL ESTER
Synonyms
4-(BOC-AMINOMETHYL-PHENYL)-METHANOL;4-(N-Boc-aMinoMethyl)benzyl alcohol;N-Boc-4-(aminomethyl)benzyl Alcohol;tert-BUTYL-4-(HYDROXYMETHYL)BENZYLCARBAMATE;4-(Aminomethyl)benzyl alcohol, N-BOC protected;4-(Aminomethyl)benzylalcohol,N-BOCprotected97%;4-(tert-Butoxycarbonylaminomethyl)benzyl alcohol;tert-Butyl [4-(hydroxymethyl)benzyl]carbamate 97%;4-(N-TERT-BUTOXYCARBONYLAMINOMETHYL)BENZYL ALCOHOL;4-(Aminomethyl)benzyl alcohol, N-BOC protected 97%
CBNumber
CB6682736
Molecular Formula
C13H19NO3
Formula Weight
237.29
MOL File
123986-64-1.mol
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(4-HYDROXYMETHYL-BENZYL)-CARBAMIC ACID TERT-BUTYL ESTER Property

Melting point:
98 °C
Boiling point:
397.2±30.0 °C(Predicted)
Density 
1.106±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
form 
solid
pka
12.19±0.46(Predicted)
color 
White
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Safety

Hazard Codes 
Xi
Hazard Note 
Irritant
HS Code 
2906290090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
H972423
Product name
(4-Hydroxymethyl-benzyl)-carbamicacidtert-butylester
Packaging
100mg
Price
$45
Updated
2021/12/16
TRC
Product number
H972423
Product name
(4-Hydroxymethyl-benzyl)-carbamicacidtert-butylester
Packaging
500mg
Price
$65
Updated
2021/12/16
BroadPharm
Product number
BP-21247
Product name
(4-HYDROXYMETHYL-BENZYL)-CARBAMICACIDTERT-BUTYLESTER
Packaging
1g
Price
$70
Updated
2021/12/16
AK Scientific
Product number
J92615
Product name
tert-Butyl4-(hydroxymethyl)benzylcarbamate
Packaging
5g
Price
$75
Updated
2021/12/16
Apolloscientific
Product number
OR14352
Product name
4-(Aminomethyl)benzylalcohol,N-BOCprotected
Purity
97%
Packaging
5g
Price
$90
Updated
2021/12/16
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(4-HYDROXYMETHYL-BENZYL)-CARBAMIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production

Synthesis

24424-99-5

39895-56-2

123986-64-1

GENERAL STEPS: A mixture of 4-(aminomethyl)benzenemethanol (1 g, 7.29 mmol) and di-tert-butyl dicarbonate (1.59 g, 7.29 mmol) in dichloromethane (30 mL) was reacted at room temperature with stirring overnight. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography with the eluent being a solvent mixture of dichloromethane and ethyl acetate (1:1, v/v) to afford tert-butyl 4-(hydroxymethyl)benzylcarbamate (0.8 g, 2.28 mmol, 31% yield) as a white solid. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 7.37 (s, 1H), 7.22 (dd, J = 27.8, 8.0 Hz, 4H), 5.13 (t, J = 5.7 Hz, 1H), 4.46 (d, J = 5.7 Hz, 2H), 4.10 (d, J = 6.1 Hz, 2H), 1.36 (s, 9H ).

References

[1] Patent: WO2006/12135, 2006, A1. Location in patent: Page/Page column 49-51
[2] Patent: US2006/293379, 2006, A1. Location in patent: Page/Page column 63
[3] Angewandte Chemie - International Edition, 2012, vol. 51, # 4, p. 941 - 944
[4] Chemical Communications, 2010, vol. 46, # 7, p. 1073 - 1075
[5] Journal of Medicinal Chemistry, 2009, vol. 52, # 1, p. 33 - 47

(4-HYDROXYMETHYL-BENZYL)-CARBAMIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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(4-HYDROXYMETHYL-BENZYL)-CARBAMIC ACID TERT-BUTYL ESTER Suppliers

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123986-64-1, (4-HYDROXYMETHYL-BENZYL)-CARBAMIC ACID TERT-BUTYL ESTERRelated Search:

Benzyl alcohol tert-butyl N-{[4-(dimethylphosphoryl)phenyl]methyl}carbamate Carbamic acid, N-[[(1R,2S)-2-aminocyclopentyl]methyl]-, 1,1-dimethylethyl ester tert-butyl N-{[1-(3-hydroxyazetidin-3-yl)cyclopropyl]methyl}carbamate tert-butyl N-[5-(prop-2-yn-1-yloxy)pentyl]carbamate 2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLIC ACID 2-TERT-BUTYL 6-METHYL 3,4-DIHYDROISOQUINOLINE-2,6(1H)-DICARBOXYLATE 4-[(tert-Butoxycarbonylamino)methyl]benzoic acid (3-HYDROXYMETHYL-BENZYL)-CARBAMIC ACID TERT-BUTYL ESTER 4-[(TERT-BUTOXYCARBONYL-METHYL-AMINO)-METHYL]-BENZOIC ACID METHYL ESTER 4-(BOC-AMIDINO)-BENZOIC ACID 2-(4-CARBOXY-PHENYL)-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 2-(TERT-BUTOXYCARBONYL)ISOINDOLINE-5-CARBOXYLIC ACID 4-(T-BOC-AMINOMETHYL)-3-CHLOROBENZOIC ACID (4-HYDROXYMETHYL-BENZYL)-CARBAMIC ACID TERT-BUTYL ESTER 4-(1-(TERT-BUTOXYCARBONYL)PIPERIDIN-2-YL)BENZOIC ACID tert-butyl 6-(1-hydroxy-1-methylethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate RARECHEM AL BO 1195

  • 4-(BOC-AMINOMETHYL-PHENYL)-METHANOL
  • (4-HYDROXYMETHYL-BENZYL)-CARBAMIC ACID TERT-BUTYL ESTER
  • 4-(N-TERT-BUTOXYCARBONYLAMINOMETHYL)BENZYL ALCOHOL
  • N-Boc-4-(aminomethyl)benzyl Alcohol
  • tert-butyl N-[[4-(hydroxymethyl)phenyl]methyl]carbamate
  • 4-(N-tert-Butoxycarbonylaminomethyl)benzyl alcohol 97%
  • tert-BUTYL-4-(HYDROXYMETHYL)BENZYLCARBAMATE
  • (4-hydroxymethyl-benzyl)-carbamic acid ter-butyl ester
  • tert-Butyl [4-(hydroxymethyl)benzyl]carbamate 97%
  • 4-(Aminomethyl)benzyl alcohol, N-BOC protected
  • 4-(N-Boc-aMinoMethyl)benzyl alcohol
  • 4-(Aminomethyl)benzyl alcohol, N-BOC protected 97%
  • tert-Butyl [4-(hydroxymethyl)benzyl]carbamate, 4-(Hydroxymethyl)benzylamine, N-BOC protected
  • 4-[N-(tert-butoxycarbonyl)aminomethyl]-1-phenylmethanol
  • 4-(Aminomethyl)benzylalcohol,N-BOCprotected97%
  • 4-(tert-Butoxycarbonylaminomethyl)benzyl alcohol
  • Carbamic acid, N-[[4-(hydroxymethyl)phenyl]methyl]-, 1,1-dimethylethyl ester
  • 1,1-Dimethylethyl N-[[4-(hydroxymethyl)phenyl]methyl]carbamate
  • 123986-64-1
  • Phenyls & Phenyl-Het
  • Miscellaneous Biochemicals
  • Aminomethyl's
  • Phenyls & Phenyl-Het