APHIDICOLIN
- Product Name
- APHIDICOLIN
- CAS No.
- 38966-21-1
- Chemical Name
- APHIDICOLIN
- Synonyms
- APC;ici69653;nsc-234714;APHIDICOLIN;(+)-APHIDICOLIN;,11a-beta,11b-beta))-;APHIDICOLIN USP/EP/BP;Aphidicolin, Ready Made Solution;(+)-APHIDICOLIN, NIGROSPORA ORYZAE;Aphidicolin, froM Nigrospora oryzae
- CBNumber
- CB6683304
- Molecular Formula
- C20H34O4
- Formula Weight
- 338.48
- MOL File
- 38966-21-1.mol
APHIDICOLIN Property
- Melting point:
- 218-220°C
- alpha
- D27 +12° (c = 1 in methanol)
- Boiling point:
- 394.61°C (rough estimate)
- Density
- 1.0057 (rough estimate)
- vapor pressure
- 0.55 hPa ( 20 °C)
- refractive index
- 1.4434 (estimate)
- Flash point:
- 87℃
- storage temp.
- 2-8°C
- solubility
- ethanol: soluble1mg/mL (stable at least a week at 4°C.)
- pka
- 14.24±0.70(Predicted)
- form
- White solid
- color
- colorless
- optical activity
- [α]27/D +12°, c = 1 in methanol(lit.)
- Water Solubility
- Soluble in DMSO or methanol. Insoluble in water. Store solutions at -20°
- Merck
- 13,734
- BRN
- 4689958
- Stability:
- Stable for 2 years from date of purchase from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- 89458
- Product name
- Aphidicolin
- Purity
- analytical standard
- Packaging
- 5mg
- Price
- $1120
- Updated
- 2024/03/01
- Product number
- 5.04744
- Product name
- InSolution Aphidicolin - CAS 38966-21-1 - Calbiochem
- Packaging
- 1mg
- Price
- $167
- Updated
- 2024/03/01
- Product number
- 178273
- Product name
- Aphidicolin
- Packaging
- 1mg
- Price
- $144
- Updated
- 2024/03/01
- Product number
- J60236
- Product name
- Aphidicolin
- Packaging
- 1mg
- Price
- $207
- Updated
- 2023/06/20
- Product number
- J60236
- Product name
- Aphidicolin
- Packaging
- 5mg
- Price
- $607
- Updated
- 2023/06/20
APHIDICOLIN Chemical Properties,Usage,Production
Description
(+)-
Chemical Properties
White crystal
Uses
A DNA polymerase inhibitor. Blocks the cell cycle at the early S-phase
Uses
(+)-Aphidicolin is a naturally occurring tetracyclic diterpene with potential antiviral and antimitotical properties.
Uses
Aphidicolin is a tetracyclic diterpene antibiotic isolated from fungi, notably Cephalosporium, Nigrospora, Harziella and Phoma. Aphidicolin has antibiotic, antiviral and antimitotic properties, blocking the cell cycle at early S-phase. This property has been used to synchronise cell division and is useful as a tool in cell differentiation research. Aphidicolin is a reversible inhibitor of DNA replication by inhibiting selected DNA polymerases. Aphidicolin induces apoptosis, prolongs the half-life of DNA methyltransferase, is active against Leishmania parasites and acts synergistically with the antitumour agents, vincristine and doxorubicin.
Definition
ChEBI: A tetracyclic diterpenoid that has an tetradecahydro-8,11a-methanocyclohepta[a]naphthalene skeleton with two hydroxymethyl substituents at positions 4 and 9, two methyl substituents at positions 4 and 11b and two hydroxy substituents at positi ns 3 and 9. An antibiotic with antiviral and antimitotical properties. Aphidicolin is a reversible inhibitor of eukaryotic nuclear DNA replication.
General Description
A cell-permeable tetracyclic diterpene antibiotic. Cell synchronization agent. Blocks the cell cycle at the early S-phase. Specific inhibitor of DNA polymerase α and δ in eukaryotic cells and in some viruses of animal origin. Potentiates apoptosis induced by arabinosyl nucleosides in leukemia cell lines. Also induces apoptosis in HeLaS3 cells, but inhibits vincristine-induced apoptosis in the p53-negative human prostate cancer cell line PC-3.
Biochem/physiol Actions
Cell permeable: yes
storage
+4°C
References
1) Syvaoja et al. (1990), DNA polymerases alpha, delta, and epsilon: three distinct enzymes from HeLa cells; Proc. Natl. Acad. Sci. USA, 87 6664 2) Urbani et al. (1995), Dissociation of nuclear and cytoplasmic cell cycle progression by drugs employed in cell synchronization; Exp. Cell Res., 219 159 3) Kuwakado et al. (1993), Aphidicolin potentiates apoptosis induced by arabinosyl nucleosides in human myeloid leukemia cell lines; Biochem. Pharmacol., 46 1909 4) Yin and Schimke (1996), Inhibition of apoptosis by overexpressing Bcl-2 enhances gene amplification by a mechanism independent of aphidicolin pretreatment; Proc. Natl. Acad. Sci. USA, 93 3394
APHIDICOLIN Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from APHIDICOLIN manufacturers
- Product
- (+)-Aphidicolin, Nigrospora oryzae 38966-21-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2020-05-09
- Product
- APHIDICOLIN 38966-21-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-06-24
- Product
- APHIDICOLIN 38966-21-1
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- ≥98%
- Supply Ability
- g/kg/Ton
- Release date
- 2019-12-25