ChemicalBook > CAS DataBase List > 3,5-BIS(METHYLSULFONYL)ANILINE

3,5-BIS(METHYLSULFONYL)ANILINE

Product Name
3,5-BIS(METHYLSULFONYL)ANILINE
CAS No.
101990-69-6
Chemical Name
3,5-BIS(METHYLSULFONYL)ANILINE
Synonyms
Dichloropyridine-4-methanol;3,5-BIS(METHYLSULFONYL)ANILINE;2,6-Dichloro-4-pyridinemethanol;3,5-BIS(METHYLSULPHONYL)ANILINE;2,6-DICHLOROPYRIDINE-4-METHANOL;4-Pyridinemethanol,2,6-dichloro-;(2,6-DICHLORO-4-PYRIDYL)METHANOL;2,6-DICHLORO-4-PYRIDINYL METHANOL;2,6-Dichloro-4-pyridinemethanol>(2,6-dichloropyridin- 4-yl)methanol
CBNumber
CB6694531
Molecular Formula
C6H5Cl2NO
Formula Weight
178.02
MOL File
101990-69-6.mol
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3,5-BIS(METHYLSULFONYL)ANILINE Property

Melting point:
0°C
Boiling point:
0°C
Density 
1.478±0.06 g/cm3(Predicted)
Flash point:
0°C
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
12.72±0.10(Predicted)
color 
White to Off-White
InChI
InChI=1S/C6H5Cl2NO/c7-5-1-4(3-10)2-6(8)9-5/h1-2,10H,3H2
InChIKey
YDGJTFCKLFLWFM-UHFFFAOYSA-N
SMILES
C1(Cl)=NC(Cl)=CC(CO)=C1
CAS DataBase Reference
101990-69-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
22-36/37/38
Safety Statements 
26-36/37/39
HazardClass 
IRRITANT
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
MNO000193
Product name
(2,6-Dichloro-4-pyridyl)methanol
Packaging
1g
Price
$107
Updated
2025/07/31
TCI Chemical
Product number
D4423
Product name
2,6-Dichloro-4-pyridinemethanol
Purity
>98.0%(GC)
Packaging
1g
Price
$54
Updated
2025/07/31
TCI Chemical
Product number
D4423
Product name
2,6-Dichloro-4-pyridinemethanol
Purity
>98.0%(GC)
Packaging
5g
Price
$246
Updated
2025/07/31
TRC
Product number
D436435
Product name
2,6-Dichloro-4-pyridinemethanol
Packaging
5g
Price
$370
Updated
2021/12/16
ChemScene
Product number
CS-W021525
Product name
2,6-Dichloropyridine-4-methanol
Packaging
1g
Price
$35
Updated
2021/12/16
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3,5-BIS(METHYLSULFONYL)ANILINE Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

2,6-Dichloro-4-pyridinemethanol is a reagent in the preparation of functionalized compounds such as bipyridines and terpyridines via Stille-type cross coupling. Also used in the preparation of fluorescent chemosensors.

Definition

ChEBI: (2,6-Dichloro-4-pyridyl)methanol is a chloropyridine.

Synthesis

5398-44-7

101990-69-6

The general procedure for the synthesis of 2,6-dichloropyridine-4-methanol from 2,6-dichloroisonicotinic acid was as follows: Preparation of Intermediate 3.1: To a stirred solution of 2,6-dichloroisonicotinic acid (10.0 g, 52.1 mmol) in THF (300 mL) at 0 °C was slowly added sulfadimethane-borane (1:1) complex (16.0 g, 210.5 mmol) to the THF solution. The reaction mixture was stirred at room temperature overnight. Subsequently, MeOH (22 mL) was carefully added to the stirred mixture under cooling in an ice bath. The reaction mixture was diluted with ethyl acetate (300 mL) and washed sequentially with 1N aqueous sodium hydroxide solution (100 mL) and saturated aqueous sodium chloride solution. The organic layer was concentrated and the residue was purified by silica gel column chromatography (eluent ratio: hexane/ethyl acetate = 7:1 to 3:1) to afford the target product 2,6-dichloropyridine-4-methanol (8.3 g, 46.6 mmol). The product was characterized by 1H NMR (300 MHz, CDCl3, 300 K): δ = 7.25 (2H); 4.72 (2H); 2.24 (1H).

References

[1] Journal of the American Chemical Society, 2005, vol. 127, # 29, p. 10124 - 10125
[2] Chemical Communications, 1998, # 15, p. 1567 - 1568
[3] Organic Letters, 2010, vol. 12, # 5, p. 940 - 943
[4] Journal fuer Praktische Chemie (Leipzig), 1938, vol. <2> 151, p. 65,79
[5] Tetrahedron, 2007, vol. 63, # 2, p. 291 - 298

3,5-BIS(METHYLSULFONYL)ANILINE Preparation Products And Raw materials

Raw materials

Toluene 2,6-Dichloroisonicotinic acid Lithium Aluminum Hydride Methanol Thionyl chloride

Preparation Products

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3,5-BIS(METHYLSULFONYL)ANILINE Suppliers

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View Lastest Price from 3,5-BIS(METHYLSULFONYL)ANILINE manufacturers

Dideu Industries Group Limited
Product
3,5-BIS(METHYLSULFONYL)ANILINE 101990-69-6
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons min
Release date
2021-09-02
Career Henan Chemical Co
Product
3,5-BIS(METHYLSULFONYL)ANILINE 101990-69-6
Price
US $500.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2018-08-04

101990-69-6, 3,5-BIS(METHYLSULFONYL)ANILINERelated Search:

METHYL 2,6-DICHLOROISONICOTINATE 3,5-BIS(METHYLSULFONYL)ANILINE 2,6-Dichloropyridine 2,3,5,6-Tetrachloropyridine-4-carboxylic acid (2,6-DICHLORO-4-PYRIDYL)METHYL THIOPHENE-2-CARBOXYLATE 3,5-DICHLOROBENZYL 2,6-DICHLOROISONICOTINATE 4-(CYANOMETHYL)PHENYL 2,6-DICHLOROISONICOTINATE (2,6-DICHLORO-4-PYRIDYL)METHYL 4-(TERT-BUTYL)BENZOATE ETHYL 2-([([(2,6-DICHLOROISONICOTINOYL)OXY]IMINO)(2,6-DICHLOROPHENYL)METHYL]AMINO)ACETATE N-[(2,6-DICHLOROISONICOTINOYL)OXY]-2-FURAMIDE O2-[(2,6-DICHLORO-4-PYRIDYL)CARBONYL]-5-NITROTHIOPHENE-2-CARBOHYDROXIMAMIDE (2,6-DICHLORO-4-PYRIDYL)METHYL 2,6-DICHLOROISONICOTINATE 2-[(4-CHLOROBENZYL)THIO]-4-(([(2,6-DICHLOROISONICOTINOYL)OXY]IMINO)METHYL)PYRIMIDINE 2-(2,6-DICHLORO-4-PYRIDYL)-5-FLUORO-4H-3,1-BENZOXAZIN-4-ONE (2,6-DICHLORO-4-PYRIDYL)METHYL N,N-DIMETHYLCARBAMATE O4-[(2,6-DICHLORO-4-PYRIDYL)CARBONYL]-3-(2,6-DICHLOROPHENYL)-5-METHYLISOXAZOLE-4-CARBOHYDROXIMAMIDE 2-CHLORO-4-FLUOROPHENYL 2,6-DICHLOROISONICOTINATE 2-ACETYLPHENYL 2,6-DICHLOROISONICOTINATE

  • 3,5-BIS(METHYLSULFONYL)ANILINE
  • 3,5-BIS(METHYLSULPHONYL)ANILINE
  • 2,6-DICHLORO-4-PYRIDINYL METHANOL
  • (2,6-DICHLORO-4-PYRIDYL)METHANOL
  • 2,6-DICHLOROPYRIDINE-4-METHANOL
  • 2,6-Dichloro-4-(hydroxymethyl)pyridine
  • 2,6-Dichloropyridine-4-methanol ,98%
  • (2,6-dichloropyridin- 4-yl)methanol
  • 2,6-Dichloro-4-pyridinemethanol
  • 4-Pyridinemethanol,2,6-dichloro-
  • 2,6-Dichloro-4-(hydroxymethyl)pyridine 95+%
  • 2,6-Dichloro-4-pyridinemethanol&gt
  • 3,5-BIS(METHYLSULFONYL)ANILINE ISO 9001：2015 REACH
  • Dichloropyridine-4-methanol
  • 101990-69-6
  • C8H11NO4S2
  • Heterocycle-Pyridine series