3,5-BIS(METHYLSULFONYL)ANILINE
- Product Name
- 3,5-BIS(METHYLSULFONYL)ANILINE
- CAS No.
- 101990-69-6
- Chemical Name
- 3,5-BIS(METHYLSULFONYL)ANILINE
- Synonyms
- Dichloropyridine-4-methanol;3,5-BIS(METHYLSULFONYL)ANILINE;2,6-Dichloro-4-pyridinemethanol;3,5-BIS(METHYLSULPHONYL)ANILINE;2,6-DICHLOROPYRIDINE-4-METHANOL;4-Pyridinemethanol,2,6-dichloro-;(2,6-DICHLORO-4-PYRIDYL)METHANOL;2,6-DICHLORO-4-PYRIDINYL METHANOL;2,6-Dichloro-4-pyridinemethanol>(2,6-dichloropyridin- 4-yl)methanol
- CBNumber
- CB6694531
- Molecular Formula
- C6H5Cl2NO
- Formula Weight
- 178.02
- MOL File
- 101990-69-6.mol
3,5-BIS(METHYLSULFONYL)ANILINE Property
- Melting point:
- 0°C
- Boiling point:
- 0°C
- Density
- 1.478±0.06 g/cm3(Predicted)
- Flash point:
- 0°C
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 12.72±0.10(Predicted)
- color
- White to Off-White
- InChI
- InChI=1S/C6H5Cl2NO/c7-5-1-4(3-10)2-6(8)9-5/h1-2,10H,3H2
- InChIKey
- YDGJTFCKLFLWFM-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC(Cl)=CC(CO)=C1
- CAS DataBase Reference
- 101990-69-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36/37/39
- HazardClass
- IRRITANT
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- MNO000193
- Product name
- (2,6-Dichloro-4-pyridyl)methanol
- Packaging
- 1g
- Price
- $107
- Updated
- 2025/07/31
- Product number
- D4423
- Product name
- 2,6-Dichloro-4-pyridinemethanol
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $54
- Updated
- 2025/07/31
- Product number
- D4423
- Product name
- 2,6-Dichloro-4-pyridinemethanol
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $246
- Updated
- 2025/07/31
- Product number
- D436435
- Product name
- 2,6-Dichloro-4-pyridinemethanol
- Packaging
- 5g
- Price
- $370
- Updated
- 2021/12/16
- Product number
- CS-W021525
- Product name
- 2,6-Dichloropyridine-4-methanol
- Packaging
- 1g
- Price
- $35
- Updated
- 2021/12/16
3,5-BIS(METHYLSULFONYL)ANILINE Chemical Properties,Usage,Production
Chemical Properties
White powder
Uses
2,6-Dichloro-4-pyridinemethanol is a reagent in the preparation of functionalized compounds such as bipyridines and terpyridines via Stille-type cross coupling. Also used in the preparation of fluorescent chemosensors.
Definition
ChEBI: (2,6-Dichloro-4-pyridyl)methanol is a chloropyridine.
Synthesis
5398-44-7
101990-69-6
The general procedure for the synthesis of 2,6-dichloropyridine-4-methanol from 2,6-dichloroisonicotinic acid was as follows: Preparation of Intermediate 3.1: To a stirred solution of 2,6-dichloroisonicotinic acid (10.0 g, 52.1 mmol) in THF (300 mL) at 0 °C was slowly added sulfadimethane-borane (1:1) complex (16.0 g, 210.5 mmol) to the THF solution. The reaction mixture was stirred at room temperature overnight. Subsequently, MeOH (22 mL) was carefully added to the stirred mixture under cooling in an ice bath. The reaction mixture was diluted with ethyl acetate (300 mL) and washed sequentially with 1N aqueous sodium hydroxide solution (100 mL) and saturated aqueous sodium chloride solution. The organic layer was concentrated and the residue was purified by silica gel column chromatography (eluent ratio: hexane/ethyl acetate = 7:1 to 3:1) to afford the target product 2,6-dichloropyridine-4-methanol (8.3 g, 46.6 mmol). The product was characterized by 1H NMR (300 MHz, CDCl3, 300 K): δ = 7.25 (2H); 4.72 (2H); 2.24 (1H).
References
[1] Journal of the American Chemical Society, 2005, vol. 127, # 29, p. 10124 - 10125
[2] Chemical Communications, 1998, # 15, p. 1567 - 1568
[3] Organic Letters, 2010, vol. 12, # 5, p. 940 - 943
[4] Journal fuer Praktische Chemie (Leipzig), 1938, vol. <2> 151, p. 65,79
[5] Tetrahedron, 2007, vol. 63, # 2, p. 291 - 298
3,5-BIS(METHYLSULFONYL)ANILINE Preparation Products And Raw materials
Raw materials
Preparation Products
3,5-BIS(METHYLSULFONYL)ANILINE Suppliers
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View Lastest Price from 3,5-BIS(METHYLSULFONYL)ANILINE manufacturers
- Product
- 3,5-BIS(METHYLSULFONYL)ANILINE 101990-69-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-02
- Product
- 3,5-BIS(METHYLSULFONYL)ANILINE 101990-69-6
- Price
- US $500.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2018-08-04