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POBN

Product Name
POBN
CAS No.
66893-81-0
Chemical Name
POBN
Synonyms
POBN;Butylpyridyloxidenitrone;-(4-pyridyl-1-oxide)nitrone;PYRIDYLOXIDE t-BUTYLNITRONE;N-tert-Butyl-α4-Pyridyl-1-oxide-tert-butyl Nitrone;A-(4-PYRIDYL-N-OXIDE-N-TERT-BUTYLNITRONE;N-TERT-BUTYL-A-(4-PYRIDYL)NITRONEN-OXIDE;N-tert-Butyl-α-(4-pyridyl-1-oxide)nitrone;α-(4-pyridyl n-oxide)-n-tert-butylnitrone
CBNumber
CB6702751
Molecular Formula
C10H14N2O2
Formula Weight
194.23
MOL File
66893-81-0.mol
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POBN Property

Melting point:
183-185 °C(lit.)
Boiling point:
330.68°C (rough estimate)
Density 
1.1444 (rough estimate)
refractive index 
1.5000 (estimate)
storage temp. 
room temp
solubility 
water: soluble10mg/mL, clear, colorless to faintly yellow
form 
White to off-white or colorless crystalline solid.
pka
0.76±0.53(Predicted)
color 
White to Light yellow
Water Solubility 
water: soluble 10mg/mL, clear, colorless to faintly yellow
BRN 
1453764
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
HS Code 
29333999
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
215430
Product name
α-(4-Pyridyl N-oxide)-N-tert-butylnitrone
Purity
99%
Packaging
1g
Price
$644
Updated
2025/07/31
Sigma-Aldrich
Product number
P9271
Product name
α-(4-Pyridyl N-oxide)-N-tert-butylnitrone
Purity
~95%
Packaging
1g
Price
$62
Updated
2023/06/20
TCI Chemical
Product number
B1735
Product name
N-tert-Butyl-alpha-(4-pyridyl-1-oxide)nitrone
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$224
Updated
2025/07/31
TCI Chemical
Product number
B1735
Product name
N-tert-Butyl-alpha-(4-pyridyl-1-oxide)nitrone
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$673
Updated
2025/07/31
Cayman Chemical
Product number
20623
Product name
POBN
Purity
≥98%
Packaging
100mg
Price
$40
Updated
2024/03/01
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POBN Chemical Properties,Usage,Production

Chemical Properties

white to pale yellow crystalline powder

Uses

Spin trap reagent used to measure ethanol oxidation to 1-hydroxyethyl radical (HER) which can bind to protein. Has also been used in studies of DNA methylation, iron-mediated polyunsaturated fatty acid peroxidation, and free-radical formation by Alzheimer β-amyloid peptide. The formation of hydroxyl radical in chondrocytes and cartilage has been detected using POBN.

Uses

POBN is a cell permeable hydrophilic spin trap for in vitro studies. It is a water soluble analog of PBN with low paramagnetic impurities and does not require any further purification. POBN has also also been used in studies of DNA methylation, iron-mediated polyunsaturated fatty acid peroxidation, and free-radical formation by Alzheimer β-amyloid peptide.

in vivo

Electron spin resonance (ESR) spectrum of radical adducts detected in bile of rats 1 h after acute Sodium formate (2 g/kg) and POBN (1.5 g/kg) i.p. administration[1].

Animal Model:Fischer male rats (300-400 g)[1]
Dosage:1.5 g/kg (Pharmacokinetic Analysis)
Administration:Injected simultaneously i.p.
Result:A strong six-line ESR signal of the POBN radical adduct was detected in the bile of rats after acute sodium formate poisoning.

POBN Preparation Products And Raw materials

Raw materials

Preparation Products

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POBN Suppliers

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66893-81-0, POBNRelated Search:

1-Hydroxy-2,2,6,6-tetramethyl-4-oxopiperidine 4,4'-DIPYRIDYL DISULFIDE 4-Picoline-N-oxide 4-Pyridinealdoxime isonicotinaldehyde oxime 1-oxide POBN

  • α-(4-Pyridyl N-oxide)-N-tert-butylnitrone,N-(4-Pyridylmethylene)-tert-butylamine N,N′-dioxide, N-tert-Butyl-α-(4-pyridyl)nitrone N′-oxide, POBN
  • alpha-(4-Pyridyl 1-oxide)-N-tert-butyl-nitrone, 99% 100MG
  • N-tert-Butyl-α-(4-pyridyl)nitrone Nμ-oxide
  • POBN, N-tert-Butyl-α-(4-pyridyl)nitrone Nμ-oxide, N-(4-Pyridylmethylene)-tert-butylamine N,Nμ-dioxide
  • 2-Methyl-N-[(pyridine 1-oxide)-4-ylmethylene]-2-propanamine oxide
  • 4-Pyridyl-1-oxide-tert-butyl Nitrone
  • N-[(Pyridine 1-oxide)-4-ylmethylene]-tert-butylamineN-oxide
  • N-[[(Pyridine-1-oxide)-4-yl]methylene]-1,1-dimethylethanamine-N-oxide
  • N-tert-Butyl-α-(4-pyridyl-1-oxide)nitrone
  • alpha-(4-Pyridyl 1-oxide)-N-tert-butyl-nitrone,99%
  • N-tert-Butyl-alpha-(4-pyridyl)nitrone N'-Oxide POBN N-(4-Pyridylmethylene)-tert-butylamine N,N'-Dioxide alpha-(4-Pyridyl N-Oxide)-N-tert-butylnitrone
  • alpha-(4-Pyridyl N-oxide)-N-tert-butylnitrone ~95%
  • alpha-(4-Pyridyl N-oxide)-N-tert-butylnitrone 99%
  • -(4-pyridyl-1-oxide)nitrone
  • <i>N</i>-<i>tert</i>-Butyl-&alpha
  • (Z)-2-Methyl-N-((1-oxidopyridin-4-yl)methylene)propan-2-amine oxide
  • Dimethylaminoparthenolide/ Tert-Butyl-[(1-Oxido-4-Pyridylidene)Methyl]-Oxo-Ammonium
  • N-(4-PYRIDYLMETHYLENE)-TERT-BUTYLAMINE N,N'-DIOXIDE
  • N-TERT-BUTYL-ALPHA-(4-PYRIDYL-1-OXIDE)NITRONE
  • N-TERT-BUTYL-ALPHA-(4-PYRIDYL)-NITRONE N'-OXIDE
  • POBN
  • ALPHA-(4-PYRIDYL-1-OXIDE)-N-T-BUTYLNITRONE
  • ALPHA-(4-PYRIDYL 1-OXIDE)-N-TERT-BUTYLNITRONE
  • ALPHA-(4-PYRIDYL N-OXIDE)-N-TERT-BUTYLNITRONE
  • Butylpyridyloxidenitrone
  • N-tert-Butyl-alpha-(4-pyridyl-1-oxide)nitrone [spin trapping
  • 1,1-dimethyl-N-(4-pyridylmethylene)ethylamine N,N'-dioxide
  • A-(4-PYRIDYL-N-OXIDE-N-TERT-BUTYLNITRONE
  • α-(4-pyridyl n-oxide)-n-tert-butylnitrone
  • N-TERT-BUTYL-A-(4-PYRIDYL)NITRONEN-OXIDE
  • N-TERT-BUTYL-ALPHA-(4-PYRIDYL-1-OXIDE)NITRONE [SPIN TRAPPING REAGENT]
  • N-tert-Butyl-alpha-(4-pyridyl-1-oxide)nitrone &gt
  • 2-Propanamine, 2-methyl-N-[(1-oxido-4-pyridinyl)methylene]-, N-oxide
  • ert-butyl-[(1-oxidopyridin-4-ylidene)methyl]-oxoazanium
  • PYRIDYLOXIDE t-BUTYLNITRONE
  • α-(4-Pyridyl <i>N</i>-oxide)-<i>N</i>-<i>tert</i>-butylnitrone
  • 66893-81-0
  • Building Blocks
  • C9 to C46
  • Spin Trapping Reagents
  • ESR Spectrometry
  • Heterocyclic Building Blocks
  • Pyridines
  • Analytical Chemistry
  • ESR Spectrometry
  • Spin Trapping Reagents
  • Analytical Reagents
  • Analytical/Chromatography
  • Building Blocks
  • C10
  • Chemical Synthesis
  • Electron Spin Resonance (ESR/EPR) Spectroscopy
  • Heterocyclic Building Blocks
  • Pyridines
  • Spectroscopy