6-BROMO-2,3-DIFLUOROBENZALDEHYDE
Uses- Product Name
- 6-BROMO-2,3-DIFLUOROBENZALDEHYDE
- CAS No.
- 360576-04-1
- Chemical Name
- 6-BROMO-2,3-DIFLUOROBENZALDEHYDE
- Synonyms
- substance-name-is-not-available;2-bromo-5,6-difluorobenzaldehyde;6-BROMO-2,3-DIFLUOROBENZALDEHYDE;Benzaldehyde, 6-broMo-2,3-difluoro-;6-Bromo-2,3-difluorobenzaldehyde,98%;6-Bromo-2,3-difluorobenzaldehyde 99%;6-BROMO-2,3-DIFLUOROBENZALDEHYDE ISO 9001：2015 REACH
- CBNumber
- CB6713180
- Molecular Formula
- C7H3BrF2O
- Formula Weight
- 221
- MOL File
- 360576-04-1.mol
6-BROMO-2,3-DIFLUOROBENZALDEHYDE Property
- Melting point:
- 39-43℃
- Boiling point:
- 225.7±35.0 °C(Predicted)
- Density
- 1.758±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Sensitive
- Air Sensitive
- InChI
- InChI=1S/C7H3BrF2O/c8-5-1-2-6(9)7(10)4(5)3-11/h1-3H
- InChIKey
- LAVPYRPTHABUAD-UHFFFAOYSA-N
- SMILES
- C(=O)C1=C(Br)C=CC(F)=C1F
Safety
- HS Code
- 2913000090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B678290
- Product name
- 6-Bromo-2,3-difluorobenzaldehyde
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- PC303096
- Product name
- 6-Bromo-2,3-difluorobenzaldehyde
- Purity
- 99%
- Packaging
- 1g
- Price
- $29
- Updated
- 2021/12/16
- Product number
- 2615-B-09
- Product name
- 6-Bromo-2,3-difluorobenzaldehyde?
- Purity
- 99%
- Packaging
- 1g
- Price
- $32
- Updated
- 2021/12/16
- Product number
- FB73258
- Product name
- 6-Bromo-2,3-Difluorobenzaldehyde
- Packaging
- 5G
- Price
- $75
- Updated
- 2021/12/16
- Product number
- PC303096
- Product name
- 6-Bromo-2,3-difluorobenzaldehyde
- Purity
- 99%
- Packaging
- 5g
- Price
- $87
- Updated
- 2021/12/16
6-BROMO-2,3-DIFLUOROBENZALDEHYDE Chemical Properties,Usage,Production
Uses
6-BROMO-2,3-DIFLUOROBENZALDEHYDE is a useful research chemical.
Synthesis
348-61-8
68-12-2
360576-04-1
General procedure for the synthesis of 6-bromo-2,3-difluorobenzaldehyde from 3,4-difluorobromobenzene and N,N-dimethylformamide: Aryl bromide (1.0 eq.) was dissolved in anhydrous THF (0.2 M) and the reaction mixture was cooled to -78 °C under nitrogen protection. LDA (2.0 M in THF, 1.1 eq.) was added dropwise over 15 min. Stirring was continued for 20 min after addition. DMF (1.2 eq.) was then added and stirred at -78 °C for 15 min. Glacial acetic acid (4.0 eq.) was added, followed immediately by water (12 times the volume of glacial acetic acid) and the reaction mixture was slowly warmed to room temperature. The phases were separated and the aqueous phase was extracted twice with ethyl acetate. The combined organic layers were washed sequentially with dilute aqueous HCl, water and brine. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated. The resulting residue was purified by silica gel column chromatography with the eluent being a hexane solution of 0 to 5% ethyl acetate to give 6-bromo-2,3-difluorobenzaldehyde (83% yield) as a yellow oil.1H NMR (CDCl3) δ: 7.31 (t, J = 1.4 Hz, 1H), 7.45 (ddd, J = 9.0, 4.1, 1.9 Hz, 1H), 7.29 (td, J = 9.2, 8.0 Hz, 1H).
References
[1] Patent: WO2004/9578, 2004, A2. Location in patent: Page 40
[2] Patent: WO2015/67549, 2015, A1. Location in patent: Page/Page column 122
[3] Patent: US2015/126449, 2015, A1. Location in patent: Paragraph 0676 - 0678
[4] Patent: WO2009/108838, 2009, A1. Location in patent: Page/Page column 67-68
6-BROMO-2,3-DIFLUOROBENZALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-BROMO-2,3-DIFLUOROBENZALDEHYDE manufacturers
- Product
- 6-BROMO-2,3-DIFLUOROBENZALDEHYDE 360576-04-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.10000000149011612kg
- Purity
- 98%
- Supply Ability
- 100kg
- Release date
- 2023-03-04