ChemicalBook > CAS DataBase List > Methyl Pyrazole-3-carboxylate
Methyl Pyrazole-3-carboxylate
- Product Name
- Methyl Pyrazole-3-carboxylate
- CAS No.
- 15366-34-4
- Chemical Name
- Methyl Pyrazole-3-carboxylate
- Synonyms
- Albb-003661;TIMTEC-BB SBB000006;methyl 1H-pyrazole-;3- pyrazole carboxylate;Methyl 3-Pyrazolecarboxylate;Methyl Pyrazole-3-carboxylate;MethylPyrazole-3-carboxylate>Methyl 1H-pyrazol-3-carboxylate;METHYL 1H-PYRAZOLE-5-CARBOXYLATE;METHYL 1H-PYRAZOLE-3-CARBOXYLATE
- CBNumber
- CB6714824
- Molecular Formula
- C5H6N2O2
- Formula Weight
- 126.11
- MOL File
- 15366-34-4.mol
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Methyl Pyrazole-3-carboxylate Property
- Melting point:
- 141-142℃
- Boiling point:
- 271℃
- Density
- 1.275
- Flash point:
- 118℃
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Soluble in methanol.
- form
- powder to crystal
- pka
- 11.04±0.10(Predicted)
- color
- White to Almost white
- λmax
- 217nm(EtOH)(lit.)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- CDS009495
- Product name
- Methyl 1<I>H</I>-pyrazole-3-carboxylate
- Purity
- Aldrich<SUP>CPR</SUP>
- Packaging
- 100 mg
- Price
- $179
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- CDS009495
- Product name
- Methyl 1H-pyrazole-3-carboxylate
- Purity
- AldrichCPR
- Packaging
- 100MG
- Price
- $174
- Updated
- 2024/03/01
TCI Chemical
- Product number
- M2444
- Product name
- Methyl Pyrazole-3-carboxylate
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $71
- Updated
- 2025/07/31
TRC
- Product number
- P842565
- Product name
- 4-PyrazolecarboxylicAcidMethylEster
- Packaging
- 2.5g
- Price
- $130
- Updated
- 2021/12/16
Usbiological
- Product number
- 287142
- Product name
- 4-Pyrazolecarboxylic acid methyl ester
- Packaging
- 1g
- Price
- $418
- Updated
- 2021/12/16
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Methyl Pyrazole-3-carboxylate Chemical Properties,Usage,Production
Uses
The methyl ester derivative of 4-Pyrazolecarboxylic Acid (P842550) used in the preparation of androgen receptor (AR) antagonists as well as pyrazole nucleosides.
Uses
The methyl ester derivative of 4-Pyrazolecarboxylic Acid (P842550), Methyl Pyrazole-3-carboxylate can be used in the preparation of androgen receptor (AR) antagonists as well as pyrazole nucleosides.
Synthesis
67-56-1
1621-91-6
15366-34-4
To a stirred solution of 1H-pyrazole-3-carboxylic acid (2 g, 17.8 mmol, 1 eq.) in methanol (20 mL) was slowly added thionyl chloride (2.5 mL, 35.5 mmol, 2 eq.). The reaction mixture was stirred at 40 °C for 5 hours. Upon completion of the reaction, the mixture was concentrated under reduced pressure to remove the solvent. The resulting residue was dissolved in dichloromethane (DCM) and washed with saturated aqueous sodium bicarbonate (NaHCO3). The organic layer was separated, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (petroleum ether/ethyl acetate=1/3, v/v) to afford methyl 1H-pyrazole-3-carboxylate (1.8 g, yield 79.6%) as a white solid.
References
[1] Journal of Medicinal Chemistry, 2008, vol. 51, # 1, p. 159 - 166
[2] Russian Journal of General Chemistry, 2011, vol. 81, # 8, p. 1745 - 1746
[3] Patent: WO2018/11628, 2018, A1. Location in patent: Paragraph 00314
[4] Heterocycles, 1996, vol. 42, # 2, p. 517 - 523
[5] Journal fuer Praktische Chemie (Leipzig), 1935, vol. <2> 143, p. 259,273
Methyl Pyrazole-3-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl Pyrazole-3-carboxylate manufacturers
Shaanxi Dideu New Materials Co. Ltd
- Product
- Methyl Pyrazole-3-carboxylate 15366-34-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-08
Honest Joy Holdings Limited
- Product
- Methyl 1H-pyrazole-5-carboxylate 15366-34-4
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99.5%
- Supply Ability
- 100 tons
- Release date
- 2022-02-08
Career Henan Chemical Co
- Product
- METHYL 1H-PYRAZOLE-3-CARBOXYLATE 15366-34-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 500kg
- Release date
- 2018-08-19
15366-34-4, Methyl Pyrazole-3-carboxylateRelated Search:
Dimethyl 1H-pyrazole-3,5-dicarboxylate
3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE)-PYRAZOLE
5-Pyrazolecarboxylic acid
4-CYANOPYRAZOLE
Pyrazole
Pyrazole-3-boronic acid
1H-PYRAZOLE-3-CARBONITRILE
DIETHYL 3,5-PYRAZOLEDICARBOXYLATE
1-ETHYL-3-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
Ethyl 5-thien-2-yl-1H-pyrazole-3-carboxylate
5-TERT-BUTYL-2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYL ESTER
ETHYL 1,5-DIMETHYL-1H-PYRAZOLE-3-CARBOXYLATE
Ethyl pyrazole-3-carboxylate
Ethyl 5-amino-4-cyano-1-phenyl-1H-pyrazole-3-carboxylate
Ethyl 3-methyl-1H-pyrazole-5-carboxylate
Ethyl 1-methyl-1H-pyrazole-5-carboxylate ,97%
ETHYL 3-(TERT-BUTYL)-1-METHYL-1H-PYRAZOLE-5-CARBOXYLATE
RARECHEM AL BF 1033