Pyrazole-3-boronic acid
- Product Name
- Pyrazole-3-boronic acid
- CAS No.
- 376584-63-3
- Chemical Name
- Pyrazole-3-boronic acid
- Synonyms
- 1H-PYRAZOLE-3-BORONIC ACID;1H-Pyrazole-5-boronic acid;e-5-boronic acid;CHEMBRDG-BB 4201615;3-Pyrazoleboronicacid;Pyrazole-3-boronicaci;Pyrazole-5-boronic acid;Pyrazole-2-boronic acid;Pyrazole-3-boronic acid;Pyrazol-3-ylboronic acid
- CBNumber
- CB8704890
- Molecular Formula
- C3H5BN2O2
- Formula Weight
- 111.89
- MOL File
- 376584-63-3.mol
Pyrazole-3-boronic acid Property
- Melting point:
- 85-88°C
- Boiling point:
- 430.4±37.0 °C(Predicted)
- Density
- 1.40±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- form
- solid
- pka
- 8.58±0.53(Predicted)
- color
- Off-white
- Water Solubility
- Soluble in water.
- InChI
- InChI=1S/C3H5BN2O2/c7-4(8)3-1-2-5-6-3/h1-2,7-8H,(H,5,6)
- InChIKey
- NEUWPDLMDVINSN-UHFFFAOYSA-N
- SMILES
- N1C=CC(B(O)O)=N1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B529883
- Product name
- 1h-Pyrazole-3-boronicAcid
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 287935
- Product name
- 1H-Pyrazol-3-yl boronic acid
- Packaging
- 500mg
- Price
- $360
- Updated
- 2021/12/16
- Product number
- W5854
- Product name
- (1H-Pyrazol-3-yl)boronicacid
- Packaging
- 5g
- Price
- $201
- Updated
- 2021/12/16
- Product number
- J92698
- Product name
- (1H-Pyrazol-3-yl)boronicacid
- Packaging
- 10g
- Price
- $250
- Updated
- 2021/12/16
- Product number
- OR8413
- Product name
- 1H-Pyrazole-5-boronicacid
- Packaging
- 10g
- Price
- $279
- Updated
- 2021/12/16
Pyrazole-3-boronic acid Chemical Properties,Usage,Production
Uses
Significantly used as synthetic intermediates. They are widely used in the production of optics.
Synthesis
449758-17-2
376584-63-3
General procedure for the synthesis of 1H-pyrazole-3-boronic acid from 1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole: To a solution of 1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole (7.6 g, 52 mmol) in tetrahydrofuran (THF, 50 mL) was added slowly at -78 °C n-butyllithium (n-BuLi, 33 mL, 2.5 M hexane solution, 82.5 mmol), followed by the addition of triisopropylborane (12.7 mL, 55 mmol) dropwise, keeping the reaction temperature at -70 °C. The reaction mixture was stirred at -70 °C for 1 hour and then slowly warmed to room temperature over 4 hours. After completion of the reaction, the reaction was quenched with 2M hydrochloric acid (HCl) and the solvent was removed under vacuum. The pH of the reaction mixture was adjusted to 6 with 1M sodium hydroxide (NaOH) solution, at which time a precipitate was formed. The precipitate was collected by filtration, washed sequentially with toluene and petroleum ether, and finally ground with ethyl acetate to afford 1H-pyrazole-3-boronic acid as a white solid (2.7 g, 48% yield), and the product could be used in subsequent reactions without further purification.
References
[1] Patent: WO2007/138072, 2007, A2. Location in patent: Page/Page column 55
[2] Journal of Medicinal Chemistry, 2004, vol. 47, # 12, p. 2995 - 3008
Pyrazole-3-boronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Pyrazole-3-boronic acid manufacturers
- Product
- 1H-Pyrazol-3-ylboronic acid 376584-63-3
- Price
- US $3.00-9.00/KG
- Min. Order
- 0.1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2025-07-05
- Product
- Pyrazole-3-boronic acid 376584-63-3
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- 100kg
- Release date
- 2018-12-22