ChemicalBook > CAS DataBase List > Pyrazole-3-boronic acid

Pyrazole-3-boronic acid

Product Name: Pyrazole-3-boronic acid
CAS No.: 376584-63-3
Chemical Name: Pyrazole-3-boronic acid
Synonyms: 1H-PYRAZOLE-3-BORONIC ACID;1H-Pyrazole-5-boronic acid;e-5-boronic acid;CHEMBRDG-BB 4201615;3-Pyrazoleboronicacid;Pyrazole-3-boronicaci;Pyrazole-5-boronic acid;Pyrazole-2-boronic acid;Pyrazole-3-boronic acid;Pyrazol-3-ylboronic acid
CBNumber: CB8704890
Molecular Formula: C3H5BN2O2
Formula Weight: 111.89
MOL File: 376584-63-3.mol

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Pyrazole-3-boronic acid Property

Melting point:: 85-88°C
Boiling point:: 430.4±37.0 °C(Predicted)
Density: 1.40±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
form: solid
pka: 8.58±0.53(Predicted)
color: Off-white
Water Solubility: Soluble in water.
InChI: InChI=1S/C3H5BN2O2/c7-4(8)3-1-2-5-6-3/h1-2,7-8H,(H,5,6)
InChIKey: NEUWPDLMDVINSN-UHFFFAOYSA-N
SMILES: N1C=CC(B(O)O)=N1

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2933199090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: B529883
Product name: 1h-Pyrazole-3-boronicAcid
Packaging: 100mg
Price: $45
Updated: 2021/12/16

Usbiological

Product number: 287935
Product name: 1H-Pyrazol-3-yl boronic acid
Packaging: 500mg
Price: $360
Updated: 2021/12/16

AK Scientific

Product number: W5854
Product name: (1H-Pyrazol-3-yl)boronicacid
Packaging: 5g
Price: $201
Updated: 2021/12/16

AK Scientific

Product number: J92698
Product name: (1H-Pyrazol-3-yl)boronicacid
Packaging: 10g
Price: $250
Updated: 2021/12/16

Apolloscientific

Product number: OR8413
Product name: 1H-Pyrazole-5-boronicacid
Packaging: 10g
Price: $279
Updated: 2021/12/16

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Pyrazole-3-boronic acid Chemical Properties,Usage,Production

Uses

Significantly used as synthetic intermediates. They are widely used in the production of optics.

Synthesis

449758-17-2

376584-63-3

General procedure for the synthesis of 1H-pyrazole-3-boronic acid from 1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole: To a solution of 1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole (7.6 g, 52 mmol) in tetrahydrofuran (THF, 50 mL) was added slowly at -78 °C n-butyllithium (n-BuLi, 33 mL, 2.5 M hexane solution, 82.5 mmol), followed by the addition of triisopropylborane (12.7 mL, 55 mmol) dropwise, keeping the reaction temperature at -70 °C. The reaction mixture was stirred at -70 °C for 1 hour and then slowly warmed to room temperature over 4 hours. After completion of the reaction, the reaction was quenched with 2M hydrochloric acid (HCl) and the solvent was removed under vacuum. The pH of the reaction mixture was adjusted to 6 with 1M sodium hydroxide (NaOH) solution, at which time a precipitate was formed. The precipitate was collected by filtration, washed sequentially with toluene and petroleum ether, and finally ground with ethyl acetate to afford 1H-pyrazole-3-boronic acid as a white solid (2.7 g, 48% yield), and the product could be used in subsequent reactions without further purification.

References

[1] Patent: WO2007/138072, 2007, A2. Location in patent: Page/Page column 55
[2] Journal of Medicinal Chemistry, 2004, vol. 47, # 12, p. 2995 - 3008

Pyrazole-3-boronic acid Preparation Products And Raw materials

Raw materials

Sodium hydride Trifluoroacetic acid 3,4-Dihydro-2H-pyran Pyrazole Tetrahydrofuran Hydrochloric acid Triisopropyl borate n-Butyllithium

Preparation Products

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View Lastest Price from Pyrazole-3-boronic acid manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 1H-Pyrazol-3-ylboronic acid 376584-63-3
Price: US $3.00-9.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-07-05

Career Henan Chemical Co

Product: Pyrazole-3-boronic acid 376584-63-3
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: 100kg
Release date: 2018-12-22

376584-63-3, Pyrazole-3-boronic acidRelated Search:

Ethyl 2-(Chlorosulfonyl)acetate Pyraclostrobin Pyrazole Folic acid Glycine Zolpidem tartrate 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one 3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE)-PYRAZOLE Dimethyl 1H-pyrazole-3,5-dicarboxylate 5-Pyrazolecarboxylic acid 4-CYANOPYRAZOLE Methyl Pyrazole-3-carboxylate DIETHYL 3,5-PYRAZOLEDICARBOXYLATE 1H-PYRAZOLE-3-CARBONITRILE Pyrazinoic acid hydrazide Boric acid 1-(Tetrahydropyran-2-yl)-1H-pyrazole-5-boronic acid pinacol ester 5-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)-1-METHYL-1H-PYRAZOLE

2H-pyrazol-3-ylboronic acid

3-Pyrazoleboronicacid

Pyrazole-5-boronic acid

Pyrazol-3-ylboronic acid

CHEMBRDG-BB 4201615

1H-Pyrazole-3-boronic acid hydrate, 95%

1H-PYRAZOL-3-YL BORONIC ACID

1H-PYRAZOLE-3-YL BORONIC ACID

1H-PYRAZOLE-3-BORONIC ACID

Pyrazole-3-boronic acid

Pyrazole-2-boronic acid

boronic acid, 1H-pyrazol-5-yl-

1H-Pyrazole-5-boronic acid

1H-Pyrazol-3-yl boronic acid ,97%

1H-pyrazol-3-ylboronic acid(SALTDATA: 2H2O)

2H-Pyrazole-3-boronic acid, 5-Borono-1H-pyrazole

1H-Pyrazole-3(5)-boronic acid

1H-Pyrazol-5-boronic acid

1H-PYRAZOLE-3-BORONIC ACID; 1H-PYRAZOLE-5-BORONIC ACID

1H-pyrazol-5-yl-5-boronic acid

Pyrazole-3-boronic acid 1H-Pyrazole-3-boronic acid

e-5-boronic acid

Boronic acid, B-1H-pyrazol-3-yl-

Pyrazole-3-boronicaci

1H-Pyrazole-3-boronic acid hydrate, 95%,

(1H-Pyrazol-3-yl)boronic acid - [P10050]

376584-63-3

C3H4BBrN2O2

C3H5BN2O2H2O

C3H5BN2O2xH2O

Boronic acid

Organoborons

Pyrazole

Boric Acid| Boric Acid Ester| Potassium Trifluoroborate