ChemicalBook > CAS DataBase List > 3,5-Dimethoxyphenylboronic acid
3,5-Dimethoxyphenylboronic acid
- Product Name
- 3,5-Dimethoxyphenylboronic acid
- CAS No.
- 192182-54-0
- Chemical Name
- 3,5-Dimethoxyphenylboronic acid
- Synonyms
- 3,5-DimethoxyphenyL;3,5-DIMETHOXYBENZENEBORONIC ACID;AKOS BRN-0893;5-DiMethoxyphenylboronic acid;3,5-DIMETHOXYPHENYLBORONIC ACID;B-(3,5-dimethoxyphenyl)boronic acid;3,5-DIMETHOXYPHENYLBORONIC ACID 99%;3,5-Dimethoxyphenylboronic acid ,98%;3,5-Dimethoxyphenylboronic acid >=95%;Boronic acid, B-(3,5-dimethoxyphenyl)-
- CBNumber
- CB6716893
- Molecular Formula
- C8H11BO4
- Formula Weight
- 181.98
- MOL File
- 192182-54-0.mol
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3,5-Dimethoxyphenylboronic acid Property
- Melting point:
- 202-207 °C
- Boiling point:
- 371.6±52.0 °C(Predicted)
- Density
- 1.19±0.1 g/cm3(Predicted)
- Flash point:
- 81℃
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Soluble in methanol.
- pka
- 7.67±0.10(Predicted)
- form
- powder to crystal
- color
- White to Light yellow to Light orange
- CAS DataBase Reference
- 192182-54-0(CAS DataBase Reference)
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Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- WGK Germany
- 3
- Hazard Note
- Irritant/Keep Cold
- HazardClass
- IRRITANT, KEEP COLD
- HS Code
- 29163990
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 715271
- Product name
- 3,5-Dimethoxyphenylboronic acid
- Purity
- ≥95%
- Packaging
- 1g
- Price
- $16.45
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- 715271
- Product name
- 3,5-Dimethoxyphenylboronic acid
- Purity
- ≥95%
- Packaging
- 5g
- Price
- $121
- Updated
- 2025/07/31
TCI Chemical
- Product number
- D3513
- Product name
- 3,5-Dimethoxyphenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 1g
- Price
- $33
- Updated
- 2025/07/31
TCI Chemical
- Product number
- D3513
- Product name
- 3,5-Dimethoxyphenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 5g
- Price
- $91
- Updated
- 2025/07/31
TCI Chemical
- Product number
- D3513
- Product name
- 3,5-Dimethoxyphenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 25g
- Price
- $301
- Updated
- 2025/07/31
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3,5-Dimethoxyphenylboronic acid Chemical Properties,Usage,Production
Chemical Properties
Gray to white solid
Uses
3,5-Dimethoxyphenylboronic acid is a useful reagent for palladium-catalyst and Suzuki-Miyaura cross coupling reactions.
Uses
Reactant for:
- Palladium-catalyzed coupling reactions
- Preparation of benzopyranone derivatives as positive GABAA receptor modulators
- Preparation of aryl alkenes via three-component coupling catalyzed by palladium
- Suzuki-Miyaura coupling
- Rhodium catalyzed cyanation with N-cyano-N-phenyl-p-methylbenzenesulfonamide
- Preparation of bisphosphonate inhibitors of human farnesyl pyrophosphate synthase
Uses
suzuki reaction
Synthesis
5419-55-6
20469-65-2
192182-54-0
1. Synthesis of 3,5-dimethoxyphenylboronic acid: After cooling the flame-dried reaction vessel under argon protection, 3,5-dimethoxybromobenzene (3 g, 13.82 mmol) and anhydrous tetrahydrofuran (36 ml) were added. The mixture was stirred until a clarified solution was formed. Subsequently, the reaction mixture was cooled to -78 °C and maintained at this temperature for 15 minutes. n-Butyllithium (10.92 ml, 2.1 M hexane solution) was slowly added and the reaction mixture continued to be stirred at -78 °C for 30 minutes. Then, triisopropyl borate (5.2 g, 27.64 mmol) was added dropwise and the reaction was continuously stirred at -78°C for 2 hours. After completion of the reaction, it was slowly warmed up to room temperature and acidified with 2 M sulfuric acid solution to pH 2. The reaction mixture was extracted with ethyl acetate, the organic phases were combined, dried with anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent. The crude product was purified by recrystallization from petroleum ether to give 3,5-dimethoxyphenylboronic acid in 92% yield.
References
[1] Patent: WO2008/118802, 2008, A1. Location in patent: Page/Page column 25-26
3,5-Dimethoxyphenylboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3,5-Dimethoxyphenylboronic acid manufacturers
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- 3,5-Dimethoxyphenylboronic acid 192182-54-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- 3,5-Dimethoxyphenylboronic acid 192182-54-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
Hebei shuoxi biotechnology co. LTD
- Product
- (3,5-dimethoxyphenyl)boronic acid 192182-54-0
- Price
- US $80.00/g
- Min. Order
- 10g
- Purity
- 99.8%
- Supply Ability
- 10tons
- Release date
- 2020-04-10
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