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Prednisolone phosphate sodium

Product Name
Prednisolone phosphate sodium
CAS No.
125-02-0
Chemical Name
Prednisolone phosphate sodium
Synonyms
PREDNISOLONE SODIUM PHOSPHATE;PREDNISONE SODIUM PHOSPHATE;codelsol;Pediapred;hydeltrasol;Prednisolone sodium phosphate CRS;optival;predsol;Ak-pred;Dojilon
CBNumber
CB6725349
Molecular Formula
C21H27Na2O8P
Formula Weight
484.39
MOL File
125-02-0.mol
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Prednisolone phosphate sodium Property

Melting point:
>197°C (dec.)
alpha 
D25 +102.5°
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Freely soluble in water, very slightly soluble in ethanol (96 per cent).
form 
Solid
color 
White to Off-White
λmax
243nm(MeOH)(lit.)
Merck 
14,7721
Stability:
Hygroscopic
CAS DataBase Reference
125-02-0(CAS DataBase Reference)
EPA Substance Registry System
Pregna-1,4-diene-3,20-dione, 11,17-dihydroxy-21-(phosphonooxy)-, disodium salt, (11.beta.)- (125-02-0)
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Safety

WGK Germany 
3
RTECS 
TU4153300
HS Code 
2937290000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Precautionary statements

P201Obtain special instructions before use.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR2816
Product name
Prednisolone Sodium Phosphate
Purity
certified reference material, pharmaceutical secondary standard
Packaging
500MG
Price
$170
Updated
2024/03/01
Sigma-Aldrich
Product number
P2810000
Product name
Prednisolone sodium phosphate
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
p2810000
Price
$153
Updated
2024/03/01
Sigma-Aldrich
Product number
1557000
Product name
Prednisolone sodium phosphate
Packaging
500mg
Price
$436
Updated
2024/03/01
TCI Chemical
Product number
D3918
Product name
Disodium Prednisolone 21-Phosphate
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$297
Updated
2024/03/01
Cayman Chemical
Product number
15933
Product name
Prednisolone Phosphate (sodium salt)
Purity
≥98%
Packaging
1g
Price
$49
Updated
2024/03/01
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Prednisolone phosphate sodium Chemical Properties,Usage,Production

Description

Prednisolone is a synthetic analog of the natural glucocorticoid corticosterone that has anti-inflammatory and immunsuppressive actions. It avidly binds both glucocorticoid and mineralocorticoid receptors (Kis = 2.4 and 37 nM). Prednisolone Phosphate, prepared as the sodium salt, is a water-soluble ester of the poorly soluble parent molecule, prednisolone. It is rapidly hydrolyzed in vivo to the parent molecule when administered intravenously. In addition, when given orally, prednisolone phosphate is more readily absorbed than prednisolone, resulting in a higher effective blood concentration of prednisolone.

Chemical Properties

White or almost white, hygroscopic, crystalline powder.

Originator

Hydeltrasol, MSD ,US ,1957

Uses

Prednisolone Sodium is a synthetic corticosteroid; metabolically interconvertible with prednisone.

Uses

antiinflammatory

Definition

ChEBI: Prednisolone sodium phosphate is an organic sodium salt of prednisolone phosphate. It is an ophthalmology drug used for the treatment of short-term inflammatory eye conditions and helps relieve inflammation, redness and irritation of the eyes. It has a role as an ophthalmology drug, an anti-inflammatory agent, a glucocorticoid receptor agonist, a prodrug and an anti-allergic agent. It is an organic sodium salt and a glucocorticoid. It contains a prednisolone phosphate(2-).

Manufacturing Process

Preparation of Prednisolone 21-Methanesulfonate: Seventy liters of dry pyridine and 7.5 kg of prednisolone are charged to a 30-gallon jacketed glasslined still. The mixture is agitated until complete solution is obtained. About 40 liters of pyridine are distilled at high vacuum while maintaining the batch temperature below 40°C. The solution is cooled to 0°C, and 2.2 liters of methanesulfonyl chloride are charged. The batch temperature is maintained between 0°C and +3°C during charging of the methanesulfonyl chloride. An atmosphere of flowing nitrogen is maintained in the still, and the mixture isagitated during the last stages of the addition. The mixture is then aged for one hour, and 15 gallons of ice water are added cautiously to the still while maintaining the temperature between 0° and 5°C.
The still contents are then transferred to a jacketed kettle equipped with an agitator, and 62 kg of cracked ice in 15 gallons of deionized water are added. The batch is aged one hour and a solution of 2 liters of concentrated (37%) hydrochloric acid in 4 gallons of deionized water is added. The batch is centrifuged and the centrifuge cake washed free of pyridine with deionized water. The centrifuge cake is then vacuum-dried at 50°C to a moisture content of about 1%, which requires about 3 days of drying. Yield about 7.77 kg (92%), according to US Patent 2,932,657.
Preparation of Prednisolone 21-Iodide: To a 30-gallon jacketed glass-lined still 64.5 lb (31.0 liters) of dimethylformamide are charged by vacuum. The still contents are agitated as 7.74 kg of dry (less than 1% moisture) prednisolone 21-methanesulfonate are charged. Then 4.02 kg of sodium iodide are charged. The still contents are heated to 57° to 60°C by means of a steam jacket and held at this temperature for 30 minutes. The batch is cooled to 35°C and 12 gallons of deionized water are added at the rate of about 1 gallon per minute. In the event the solution becomes cloudy, addition of water is interrupted and the mixture agitated for five minutes before resumption of water addition. After all of the water is added, the batch is transferred to a 50 gallon kettle equipped with agitator and an additional 16.7 gallons of deionized water are added. The batch is cooled to 0° to 5°C and aged for one hour. The batch is filtered and the filter cake washed and vacuum dried at 30° to 35°C to a moisture content of less than 1%. Yield about 7.95 kg (96%), according to US Patent 2,932,657.
Preparation of Prednisolone 21-Disodium Phosphate: Acetonitrile (50.0 ml) containing phosphoric acid (90%; 1.0 ml) was treated with triethylamine (3.0 ml) and the solution added to 11β,17α-dihydroxy-21-iodopregna-1,4-diene-3,20dione (1.0 gram; powdered). The mixture was refluxed for 2.75 hours and the solvent was then evaporated under reduced pressure to give a yellow oil. The oil was taken up in methanol (25 ml) and titrated to pH 10.9 with sodium hydroxide in methanol (N) using a pH meter. The precipitate was filtered off and the filtrate evaporated to a gum under reduced pressure. The gum was taken up in methanol (5 ml), filtered through filter paper and acetone (100 ml) was added to the filtrate. The precipitate was filtered off, washed with acetone and dried at 100°C/1 mm for 0.75 hour giving a pale yellow solid, prednisolone disodium phosphate (0.74 gram), which was completely soluble in water, according to US Patent 2,936,313.

brand name

Hydeltrasol (Merck); Inflamase (Novartis); Metreton (Schering); Orapred (BioMarin); Pediapred (UCB); Predair (Pharmafair).

Therapeutic Function

Glucocorticoid

Prednisolone phosphate sodium Preparation Products And Raw materials

Raw materials

Preparation Products

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Prednisolone phosphate sodium Suppliers

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View Lastest Price from Prednisolone phosphate sodium manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Prednisolone phosphate sodium 125-02-0
Price
US $1.00/Kg/Bag
Min. Order
1KG
Purity
96.0%-103.0%,EP9
Supply Ability
200kg/month
Release date
2021-06-01
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Prednisolone phosphate sodium 125-02-0
Price
US $0.00/Kg/Bag
Min. Order
1KG
Purity
96.0%～103.0%; EP9.0
Supply Ability
1000kg/month
Release date
2021-06-03
Wuhan Haorong Biotechnology Co.,Ltd
Product
Prednisolone phosphate sodium 125-02-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
5000
Release date
2023-07-27

125-02-0, Prednisolone phosphate sodiumRelated Search:

Tylosin phosphate Triethyl phosphate Sodium polyphosphate Solvent Red 43 Trisodium phosphate Zinc phosphate Pentasodium triphosphate hexhydrate Calcium phosphate Ethylenediaminetetraacetic acid disodium salt Disodium succinate Prednisolone Methylprednisolone Sodium Phosphate Monobasic Monohydrate Methylprednisolone acetate Prednisolone-21-acetate Meprednisone Prednisone Prednisolone sodium succinate

  • SODIUM PREDNISOLONE-21-PHOSPHATE
  • PREDNISONE SODIUM PHOSPHATE
  • prednisolone phosphate sodium
  • PREDNISOLONE SODIUM PHOSPHATE
  • PREDNISOLONE 21-PHOSPHATE, DISODIUM SALT
  • (11beta)-
  • 4-diene-3,20-dione,11-beta,17,21-trihydroxy-pregna-21-(dihydrogenphosphat
  • codelsol
  • e),disodiumsalt
  • hydeltrasol
  • inflamase
  • optival
  • phortisolone
  • prednesol
  • prednisolone21-phosphatedisodium
  • prednisolonedisodiumphosphate
  • predsol
  • predsolan
  • pregna-1,4-diene-3,20-dione,11,17-dihydroxy-21-(phosphonooxy)-,disodiumsalt,
  • prozorin
  • sodiumprednisolonephosphate
  • solucort
  • Pregna-1,4-diene-3,20-dione, 11,17-dihydroxy-21-(phosphonooxy)-, disodium salt, (11.beta.)-
  • PREDNISOLONESODIUMPHOSPHATE,USP
  • Ak-pred
  • Dojilon
  • Hefasolon
  • Metreton
  • Pediapred
  • Pregna-1,4-diene-3,20-dione, 11,17-dihydroxy-21-(phosphonooxy)-, disodium salt, (11b)- (9CI)
  • Pregna-1,4-diene-3,20-dione, 11b,17,21-trihydroxy-, 21-(dihydrogen phosphate), disodium salt (7CI, 8CI)
  • Pregna-1,4-diene-3,20-dione, 11b,17,21-trihydroxy-, 21-phosphate, disodium salt (6CI)
  • Solu-Predalone
  • Prednisolone 21-sodium phosphate
  • Prednisolone phospha
  • prednisolone 21-(disodium phosphate)
  • PrednisoloneSodiumPhosphateBp/Usp/Ep
  • Prednisolone Series Base 50-24-8 / Phosphate
  • Prednisolone Sodium Phosphate (500 mg)
  • Prednisolone SodiuM Phosphate USP/EP
  • Prednisolone Phosphate (sodium salt)
  • disodium [2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] phosphate
  • )-6,9-Difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-3-oxoandrosta-1,4-diene-17-carboxylic Acid
  • -Hydroxy-17,20:20,21-bis(methylenedioxy)pregn-4-en-3-one Nitrite
  • )-21-Chloro-9-fluoro-11-hydroxy-17-(1-oxopropoxy)pregna-1,4-diene-3,20-dione
  • )-9-Fluoro-11,21-dihydroxy-16-methyl-pregna-1,4,16-triene-3,20-dione
  • 17,21-Trihydroxy-16&alpha
  • -methyl-pregn-4-ene-3,20-dione 21-Acetate
  • 17,20&beta
  • 21-Tetrahydroxypregna-1,4-dien-3-one 21-Acetate
  • -Hydroxy-3-oxo-androsta-1,4-diene-17&beta
  • )-17-(Acetyloxy)-11-[4-(dimethylamino)phenyl]-3-hydroxy-19-norpregna-1,3,5(10)-trien-20-one-d3
  • 21-Tetrahydroxypregna-1,4-diene-3,20-dione-d3
  • )-11-Hydroxy-16-methyl-17,21-bis(1-oxoacetoxy)-pregna-1,4-diene-3,20-dione
  • 17,21-Trihydroxy-3,20-dioxo-cyclic-18,11-hemiacetal Pregn-4-en-18-al Triacetate
  • -methyl-17,20:20,21-bis(methylenedioxy)-pregn-4-en-3-one
  • )-11,17,21-Trihydroxy-pregna-1,4,8-triene-3,20-dione
  • -Hydroperoxy Dienogest