ChemicalBook > CAS DataBase List > 5-FLUORO-2-METHYLBENZOXAZOLE

5-FLUORO-2-METHYLBENZOXAZOLE

Product Name
5-FLUORO-2-METHYLBENZOXAZOLE
CAS No.
701-16-6
Chemical Name
5-FLUORO-2-METHYLBENZOXAZOLE
Synonyms
fluoromethylbenzoxazole;5-FLUORO-2-METHYLBENZOXAZOLE;Benzoxazole, 5-fluoro-2-methyl-;5-Fluoro-2-methylbenzoxazole>5-Fluoro-2-methylbenzo[d]oxazole;5-Fluoro-2-methyl-1,3-benzoxazole;5-FLUORO-2-METHYLBENZOXAZOLE 97+%
CBNumber
CB6748179
Molecular Formula
C8H6FNO
Formula Weight
151.14
MOL File
701-16-6.mol
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5-FLUORO-2-METHYLBENZOXAZOLE Property

Boiling point:
90°C 10mm
Density 
1.23
refractive index 
1.5210 to 1.5240
storage temp. 
Sealed in dry,Room Temperature
pka
1.05±0.10(Predicted)
Specific Gravity
1.23
Appearance
Yellow to orange Liquid
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Safety

Hazard Codes 
Xn
Risk Statements 
36/37/38-22
Safety Statements 
26-36/37/39
HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
F0420
Product name
5-Fluoro-2-methylbenzoxazole
Purity
>97.0%(GC)
Packaging
1g
Price
$44
Updated
2025/07/31
TCI Chemical
Product number
F0420
Product name
5-Fluoro-2-methylbenzoxazole
Purity
>97.0%(GC)
Packaging
5g
Price
$131
Updated
2025/07/31
TRC
Product number
F401718
Product name
5-Fluoro-2-Methylbenzoxazole
Packaging
50mg
Price
$45
Updated
2021/12/16
Apolloscientific
Product number
PC906427
Product name
5-Fluoro-2-methylbenzoxazole
Purity
97%
Packaging
1g
Price
$200
Updated
2021/12/16
AK Scientific
Product number
6772AL
Product name
5-Fluoro-2-methylbenzoxazole
Packaging
5g
Price
$244
Updated
2021/12/16
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5-FLUORO-2-METHYLBENZOXAZOLE Chemical Properties,Usage,Production

Uses

5-Fluoro-2-Methylbenzoxazole is used as a reactant in the preparation of benzothiadiazine compounds as CD73 inhibitors.

Synthesis

399-97-3

78-39-7

701-16-6

Procedure for the synthesis of 5-fluoro-2-methylbenzoxazole: 2-amino-4-fluorophenol (1.01 g, 7.95 mmol, 1.0 eq.), triethyl orthoacetate (1.60 mL, 8.7 mmol, 1.1 eq.), and bismuth(III) trifluoromethanesulfonate (50 mg) were mixed and stirred for 30 min at room temperature. Upon completion of the reaction, the reaction mixture was diluted with dichloromethane and purified by rapid chromatography on silica gel (eluent: dichloromethane) to afford 5-fluoro-2-methylbenzoxazole as a clear liquid in a yield of 1.045 g (87% yield). The liquid could be converted to a crystalline solid at lower than 5 °C. Mass spectrum (MALDI-TOF): MH+ = 152. UV/Vis spectrum (methanol): maximum absorption wavelength λmax = 282, 276, 230 nm. 1H NMR (400 MHz, CDCl3): δ 2.60 (s, 3H), 7.02 (1H, td), 7.33 (1H, dd), 7.39 (1H, dd).

References

[1] Patent: WO2008/40994, 2008, A2. Location in patent: Page/Page column 25
[2] Patent: WO2017/98421, 2017, A1. Location in patent: Page/Page column 223

5-FLUORO-2-METHYLBENZOXAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-FLUORO-2-METHYLBENZOXAZOLE Suppliers

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View Lastest Price from 5-FLUORO-2-METHYLBENZOXAZOLE manufacturers

Honest Joy Holdings Limited
Product
5-Fluoro-2-methylbenzoxazole 701-16-6
Price
US $0.00/KG
Min. Order
1KG
Purity
97.4%
Supply Ability
100 tons
Release date
2022-01-14
Career Henan Chemical Co
Product
5-FLUORO-2-METHYLBENZOXAZOLE 701-16-6
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000KGS
Release date
2019-12-23

701-16-6, 5-FLUORO-2-METHYLBENZOXAZOLERelated Search:

2-Methylbenzoxazole DL-ISOSERINE 6-FLUORO-2-METHYLBENZOXAZOLE 97,6-FLUORO-2-METHYLBENZOXAZOLE 97% DL-Isoserine 6-FLUORO-2-METHYLBENZOXAZOLE 5-Fluorobenzoxazole 5-FLUORO-1,3-BENZOXAZOLE-2-CARBOXYLIC ACID 5-FLUOROBENZO[D]OXAZOLE-2-CARBALDEHYDE 5-FLUORO-2-METHYLBENZOXAZOLE

  • fluoromethylbenzoxazole
  • 5-FLUORO-2-METHYLBENZOXAZOLE
  • 5-FLUORO-2-METHYLBENZOXAZOLE 97+%
  • 5-Fluoro-2-methylbenzo[d]oxazole
  • 5-Fluoro-2-methyl-1,3-benzoxazole
  • 5-Fluoro-2-methylbenzoxazole&gt
  • Benzoxazole, 5-fluoro-2-methyl-
  • 701-16-6