5-FLUORO-2-METHYLBENZOXAZOLE
- Product Name
- 5-FLUORO-2-METHYLBENZOXAZOLE
- CAS No.
- 701-16-6
- Chemical Name
- 5-FLUORO-2-METHYLBENZOXAZOLE
- Synonyms
- fluoromethylbenzoxazole;5-FLUORO-2-METHYLBENZOXAZOLE;Benzoxazole, 5-fluoro-2-methyl-;5-Fluoro-2-methylbenzoxazole>5-Fluoro-2-methylbenzo[d]oxazole;5-Fluoro-2-methyl-1,3-benzoxazole;5-FLUORO-2-METHYLBENZOXAZOLE 97+%
- CBNumber
- CB6748179
- Molecular Formula
- C8H6FNO
- Formula Weight
- 151.14
- MOL File
- 701-16-6.mol
5-FLUORO-2-METHYLBENZOXAZOLE Property
- Boiling point:
- 90°C 10mm
- Density
- 1.23
- refractive index
- 1.5210 to 1.5240
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 1.05±0.10(Predicted)
- Specific Gravity
- 1.23
- Appearance
- Yellow to orange Liquid
Safety
- Hazard Codes
- Xn
- Risk Statements
- 36/37/38-22
- Safety Statements
- 26-36/37/39
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- F0420
- Product name
- 5-Fluoro-2-methylbenzoxazole
- Purity
- >97.0%(GC)
- Packaging
- 1g
- Price
- $44
- Updated
- 2025/07/31
- Product number
- F0420
- Product name
- 5-Fluoro-2-methylbenzoxazole
- Purity
- >97.0%(GC)
- Packaging
- 5g
- Price
- $131
- Updated
- 2025/07/31
- Product number
- F401718
- Product name
- 5-Fluoro-2-Methylbenzoxazole
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- PC906427
- Product name
- 5-Fluoro-2-methylbenzoxazole
- Purity
- 97%
- Packaging
- 1g
- Price
- $200
- Updated
- 2021/12/16
- Product number
- 6772AL
- Product name
- 5-Fluoro-2-methylbenzoxazole
- Packaging
- 5g
- Price
- $244
- Updated
- 2021/12/16
5-FLUORO-2-METHYLBENZOXAZOLE Chemical Properties,Usage,Production
Uses
5-Fluoro-2-Methylbenzoxazole is used as a reactant in the preparation of benzothiadiazine compounds as CD73 inhibitors.
Synthesis
399-97-3
78-39-7
701-16-6
Procedure for the synthesis of 5-fluoro-2-methylbenzoxazole: 2-amino-4-fluorophenol (1.01 g, 7.95 mmol, 1.0 eq.), triethyl orthoacetate (1.60 mL, 8.7 mmol, 1.1 eq.), and bismuth(III) trifluoromethanesulfonate (50 mg) were mixed and stirred for 30 min at room temperature. Upon completion of the reaction, the reaction mixture was diluted with dichloromethane and purified by rapid chromatography on silica gel (eluent: dichloromethane) to afford 5-fluoro-2-methylbenzoxazole as a clear liquid in a yield of 1.045 g (87% yield). The liquid could be converted to a crystalline solid at lower than 5 °C. Mass spectrum (MALDI-TOF): MH+ = 152. UV/Vis spectrum (methanol): maximum absorption wavelength λmax = 282, 276, 230 nm. 1H NMR (400 MHz, CDCl3): δ 2.60 (s, 3H), 7.02 (1H, td), 7.33 (1H, dd), 7.39 (1H, dd).
References
[1] Patent: WO2008/40994, 2008, A2. Location in patent: Page/Page column 25
[2] Patent: WO2017/98421, 2017, A1. Location in patent: Page/Page column 223
5-FLUORO-2-METHYLBENZOXAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
5-FLUORO-2-METHYLBENZOXAZOLE Suppliers
- Tel
- 320-37350700
- Fax
- +32 (0)37350701
- sales@tcieurope.eu
- Country
- Europe
- ProdList
- 23671
- Advantage
- 75
View Lastest Price from 5-FLUORO-2-METHYLBENZOXAZOLE manufacturers
- Product
- 5-Fluoro-2-methylbenzoxazole 701-16-6
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.4%
- Supply Ability
- 100 tons
- Release date
- 2022-01-14
- Product
- 5-FLUORO-2-METHYLBENZOXAZOLE 701-16-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000KGS
- Release date
- 2019-12-23