SMILAGENIN

Product Name: SMILAGENIN
CAS No.: 126-18-1
Chemical Name: SMILAGENIN
Synonyms: Cogane;Nsc93747;PYM50028;AI3-44895;PYM 50028;SMILAGENIN;ESMILAGENIN;ISOSARSAPOGENIN;Smilax china L;ISOSARSAPOGENINE
CBNumber: CB6750868
Molecular Formula: C27H44O3
Formula Weight: 416.64
MOL File: 126-18-1.mol

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SMILAGENIN Property

Melting point:: ~185 °C
alpha: D25 -69° (c = 0.5 in chloroform)
Boiling point:: 474.91°C (rough estimate)
Density: 1.0362 (rough estimate)
refractive index: 1.4700 (estimate)
storage temp.: Store at -20°C
solubility: Ethanol: ≥ 10 mg/mL (24.00 mM); DMSO: < 1 mg/mL (insoluble or slightly soluble)
form: Solid
pka: 15.14±0.70(Predicted)
color: White to off-white

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Safety

WGK Germany: 3
F: 10

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TCI Chemical

Product number: M3546
Product name: Smilagenin
Packaging: 250MG
Price: $141
Updated: 2025/07/31

Biosynth Carbosynth

Product number: FS65169
Product name: Smilagenin
Packaging: 10mg
Price: $170
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FS65169
Product name: Smilagenin
Packaging: 25mg
Price: $325
Updated: 2021/12/16

ChemScene

Product number: CS-0025639
Product name: Smilagenin
Purity: >98.0%
Packaging: 50mg
Price: $350
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FS65169
Product name: Smilagenin
Packaging: 50mg
Price: $500
Updated: 2021/12/16

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SMILAGENIN Chemical Properties,Usage,Production

Uses

Smilagenin (SMI) is a small-molecule steroidal sapogenin from Anemarrhena asphodeloides and Pelargonium hortorum widely used in traditional Chinese medicine for treating chronic neurodegeneration diseases[1]. Smilagenin (SMI) improves memory of aged rats by increasing the muscarinic receptor subtype 1 (M1)-receptor density[2]. Smilagenin (SMI) attenuates Aβ(25-35)-induced neurodegenerationvia stimulating the gene expression of brain-derived neurotrophic factor, may represents a novel therapeutic strategy for AD[3].

Definition

ChEBI: An oxaspiro compound that is(5beta,25R)-spirostan substituted by a beta-hydroxy group at position 3.

in vivo

Smilagenin (intragastric administration; 10 or 26 mg/kg, once daily; 60 days) prevents the impairment of dopaminergic neurons in chronic MPTP/probenecid-induced mouse model^[2].

Animal Model:	MPTP/probenecid-induced mouse model^[2]
Dosage:	10 or 26 mg/kg
Administration:	Intragastric administration; 10 or 26 mg/kg; once daily; 60 days
Result:	Ameliorated locomotor ability of MPTP/probenecid-lesioned mice.

IC 50

mAChR1

Purification Methods

Chromatograph smilagenin on active Al2O3 and elute with *C6H6, then recrystallise it from Me2CO, aqueous EtOH (m 187-188o) or MeOH. The acetate crystallises from MeOH with m 152o and [] D 25 -59.6o, [] 546 25 –68.9o (c 0.25, CHCl3). [Askew J Chem Soc 1399 1936 and 1402 1936, Scheer et al. J Am Chem Soc 77 6411955, Beilstein 19 III/IV 826.]

References

[1] He X, et al. Smilagenin Protects Dopaminergic Neurons in Chronic MPTP/Probenecid-Lesioned Parkinson's Disease Models. Front Cell Neurosci. 2019 Feb 5;13:18. DOI:10.3389/fncel.2019.00018
[2] Hu Y, et al. Regulation of M1-receptor mRNA stability by smilagenin and its significance in improving memory of aged rats. Neurobiol Aging. 2010 Jun;31(6):1010-9. DOI:10.1016/j.neurobiolaging.2008.06.008
[3] Zhang R, et al. Smilagenin attenuates beta amyloid (25-35)-induced degeneration of neuronal cells via stimulating the gene expression of brain-derived neurotrophic factor. Neuroscience. 2012 May 17;210:275-85 DOI:10.1016/j.neuroscience.2012.03.017

SMILAGENIN Preparation Products And Raw materials

Raw materials

Preparation Products

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SMILAGENIN Suppliers

China 49 China Hong Kong 1 Germany 2 India 1 Switzerland 1 United Kingdom 5 United States 11 Global 70

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

ShangHai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847 13636370518
Fax: 021-55068248
Email: shyysw007@163.com
Country: China
ProdList: 4999
Advantage: 60

Chengdu Biopurify Phytochemicals Ltd.

Tel: +86-028-82633397 18982077548
Fax: +86-28-82633165
Email: cwb1@biopurify.cn
Country: China
ProdList: 2376
Advantage: 60

UHN Shanghai Research & Development Co., Ltd.

Tel: 021-58958002 18930822973
Fax: +86 (21) 5895-8628
Email: sales@uhnshanghai.com
Country: China
ProdList: 998
Advantage: 58

Shanghai Tauto Biotech Co., Ltd.

Tel: 021-51320588
Fax: 0086-21-51320502
Email: tauto@tautobiotech.com
Country: China
ProdList: 3988
Advantage: 66

Chengdu Push Bio-Technology Co., Ltd.

Tel: 028-028-85370565-229-229 18080489829
Email: 18080489829@163.com
Country: China
ProdList: 8250
Advantage: 60

Nanjing Digger Medical Technology Co. Ltd.

Tel: 025-025-51191215 18013836722
Fax: 025-51191215
Email: 2399235533@qq.com
Country: China
ProdList: 4933
Advantage: 58

Dideu Industries Group Limited

Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Country: China
ProdList: 20284
Advantage: 58

TopScience Biochemical

Tel: 00852-68527855
Fax: 00852-26406298
Email: info@itopbiochem.com
Country: China Hong Kong
ProdList: 902
Advantage: 58

PCL - Business, Laboratory Pharmaceutical

Tel: 19150123681
Fax: QQ:3008022628
Email: Hu.xinyue@purechemland.com
Country: China
ProdList: 3566
Advantage: 58

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View Lastest Price from SMILAGENIN manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: Smilagenin 126-18-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-11-21

Zhuozhou Wenxi import and Export Co., Ltd

Product: (25R)-5β-spirostan-3β-ol 126-18-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-26

126-18-1, SMILAGENINRelated Search:

DIISOBUTYL ETHER COPROSTANOL 1-TETRACOSANOL 1,1-Dimethoxyoctane SEC-BUTYL ETHER LAURYL ALDEHYDE DIMETHYL ACETAL HEPTANAL-DIETHYLACETAL N-HEPTADECYLCYCLOHEXANE ISOVERTAL 411 L COPROSTANE n-Docosanol 1,1-Dimethoxydecane HEXALDEHYDE DIETHYL ACETAL SMILAGENIN 2-heptyltetrahydrofuran Sarsasapogenin SMILAGENIN(RG) ETIOCHOLANE

5BETA,20ALPHA,22ALPHA,25D-SPIRANOSTAN-3BETA-OL

5-BETA, 20-ALPHA, 22-ALPHA, 25D-SPIROSTAN-3-BETA-OL

25R,5BETA-SPIROSTAN-3BETA-OL

(25R)-SPIROSTAN-3BETA-OL

16,22:22,26-BIS(EPOXY)CHOLESTAN-3BETA-OL

SMILAGENIN

(25r)-spirostan-3β-ol

(25R)-Spirostan-3β-ol, 16,22:22,26-Bis(epoxy)cholestan-3β-ol

5.beta.-Spirostan-3.beta.-ol, (25R)-

Nsc93747

Spirostan-3-ol, (3.beta.,5.beta.,25R)-

(3β,5β,25R)-Spirostan-3-ol

16,22:22,26-Bis(epoxy)cholestan-3β-ol

ISOSARSAPOGENIN

ISOSARSAPOGENINE

ISOSARSASAPOGENIN

ESMILAGENIN

Smilax china L

Spirostan-3-ol, (3β,5β,25R)-

(25R)-5β-spirostan-3β-ol

SMILAGENIN USP/EP/BP

AI3-44895

Cogane

PYM 50028

PYM50028

5β, 20α, 22α, 25D-SPIROSTAN-3β-OL

126-18-1

SA - SM

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