Tigogenin

Product Name: Tigogenin
CAS No.: 77-60-1
Chemical Name: Tigogenin
Synonyms: Nsc93754;TIGOGENIN;Ticogenin;Sisalagenin;TIGOGENIN90%;Sisal saponin;Spirostan-3-ol;SMILAGENIN(RG);Trigonegenin B;Tsosarsasaprgein
CBNumber: CB1669512
Molecular Formula: C27H44O3
Formula Weight: 416.64
MOL File: 77-60-1.mol

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Tigogenin Property

Melting point:: 202-204°C
alpha: -68 º (c=0.8g/100ml, CHCl3)
Boiling point:: 474.91°C (rough estimate)
Density: 1.0362 (rough estimate)
refractive index: 1.4700 (estimate)
storage temp.: -20°C Freezer, Under inert atmosphere
solubility: Chloroform (Slightly)
pka: 15.14±0.70(Predicted)
form: Solid
color: Off-White
CAS DataBase Reference: 77-60-1(CAS DataBase Reference)
NIST Chemistry Reference: Tigogenin(77-60-1)

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Safety

RTECS: WH1443500

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL83916
Product name: Tigogenin
Purity: phyproof? Reference Substance
Packaging: 10MG
Price: $457
Updated: 2024/03/01

Cayman Chemical

Product number: 30137
Product name: Tigogenin
Packaging: 10mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 30137
Product name: Tigogenin
Packaging: 250mg
Price: $745
Updated: 2024/03/01

Cayman Chemical

Product number: 30137
Product name: Tigogenin
Packaging: 50mg
Price: $193
Updated: 2024/03/01

Cayman Chemical

Product number: 30137
Product name: Tigogenin
Packaging: 100mg
Price: $341
Updated: 2024/03/01

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Tigogenin Chemical Properties,Usage,Production

Description

Tigogenin is a steroidal sapogenin that has been found in A. sisalana and has diverse biological activities. It increases the proliferation rate of, as well as mRNA levels of genes encoding the osteoblastic differentiation markers Cbfa1, collagen type I, and osteocalcin in, mouse bone marrow stromal cells (BMSCs) in a concentration-dependent manner. It also increases matrix calcium deposition in BMSCs when used at concentrations of 30 and 90 μM. Tigogenin is active against the fungus A. fumigatus (MIC₅₀ = 16 μg/ml). It inhibits carrageenan-induced paw edema in rats when administered at a dose of 4.2 μg/kg.

Chemical Properties

mp 196-208C° LOD ≤0.5%

Uses

Tigogenin is a saponin structurally similar to Diosgenin (D484700) and acts as a natural plant steroid which induces apoptosis in rheumatoid arthritic fibroblast-like synoviocytes.

Definition

ChEBI: Tigogenin is a widely used steroidal sapogenin isolated from several plant species and used for synthesizing steroid drugs. It has a role as a gout suppressant and a plant metabolite.

Tigogenin Preparation Products And Raw materials

Raw materials

Preparation Products

Androst-3-ol-17-one 3-p-toluenesulfonate 3-Acetyloxy-16-methylpregna-9(11),16-dien-20-one 3-Acetyloxypregn-16-en-20-one 16-Methylpregnane-17,21-diol-3,20-dione 21-acetate 17-alpha-hydroxy-16-alpha-methyl-3,20-dioxopregna- 1,4-dien-21-yl acetate Oxymetholone 16,17-Epoxy-3-hydroxy-16-methyl-pregn-9(11)-ene-20-one-3-acetate 3beta-hydroxy-5alpha-pregna-9(11),16-dien-20-one 3-acetate

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Tigogenin Suppliers

China 184 Europe 2 Germany 1 India 1 Switzerland 1 United Kingdom 5 United States 25 Global 219

Shanghai Yingxin Laboratory Equipment Co., Ltd.

Tel: 021-021-59178156 17002132182
Email: 3146474380@qq.com
Country: China
ProdList: 11609
Advantage: 58

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15848
Advantage: 69

Chembest Research Laboratories Limited

Tel: 021-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6011
Advantage: 61

XiaoGan ShenYuan ChemPharm co,ltd

Tel: 0712-0712-2580635 15527768850
Email: 1791901229@qq.com
Country: China
ProdList: 8849
Advantage: 52

BEST-REAGENT

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11726
Advantage: 57

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7815
Advantage: 57

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: +8618575662672 18575662672
Fax: 021 51613951
Email: mzeng@3wpharm.com
Country: China
ProdList: 9748
Advantage: 57

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4647
Advantage: 58

BioBioPha Co., Ltd.

Tel: 0871-65217109 13211707573;
Fax: 0871-65215563
Email: y.liu@mail.biobiopha.com
Country: China
ProdList: 5654
Advantage: 65

ShangHai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847 13636370518
Fax: 021-55068248
Email: shyysw007@163.com
Country: China
ProdList: 4941
Advantage: 60

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View Lastest Price from Tigogenin manufacturers

Hebei Duling International Trade Co. LTD

Product: Tigogenin 77-60-1
Price: US $56.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000 tons
Release date: 2023-02-21

Shanghai Standard Technology Co., Ltd.

Product: Tigogenin 77-60-1
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-11-22

Honest Joy Holdings Limited

Product: Tigogenin 77-60-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.9%
Supply Ability: 100 tons
Release date: 2022-02-18

77-60-1, TigogeninRelated Search:

Ginsenoside Rh2 Ginseng extract Saponin TRIBULOSIDE Hecogenin Diosgenin Escin PAMAQUESIDE DIGITONIN TIQUESIDE HECOGENIN ACETATE Escin sodium (25R)-5ALPHA-SPIROSTAN-2ALPHA,3BETA-DIOL Ginsenosides SMILAGENIN TIGOGENIN ACETATE nigrumnin I GSK-3 BETA

TIGOGENIN

(25r)-5-alpha-spirostan-3-beta-o

25R,5ALPHA-SPIROSTAN-3BETA-OL

5-ALPHA, 20-ALPHA, 22-ALPHA, 25D-SPIROSTAN-3-BETA-OL

(25R)-5-Spirostan-3-ol

(3-beta,5-alpha,25r)-spirostan-3-o

5-alpha-spirostan-3-beta-ol

5alpha-Spirostan-3beta-ol, (25R)-

Spiro[8H-naphth[2',1':4,5]indeno[2,1-b]furan-8,2'-[2H]pyran], spirostan-3-ol deriv.

Spirostan-3-ol

Spirostan-3-ol, (3beta,5alpha,25R)-

Ticogenin

Tsosarsasaprgein

(5alpha,25R)-spirostan-3beta-ol

TIGOGENIN90%

SMILAGENIN(RG)

(3,5,25R)-3-Hydroxy-spirostane

(3-beta,5-alpha,25r)-spirostan-3-ol

TIGOGENIN (91%: 95%) (5A,25R)-SPIROSTAN-3B-OL)

Sisalagenin

(25R)-5a-Spirostan-3b-ol

(25R)-3β-Hydroxy-5α-spirostane

Trigonegenin B

Nsc93754

22-Isoallospirostan-3β-ol

(2aS,2'R,4S,5'R,6aS,6bS,8aS,8bR,9S,11aS,12aS,12bR)-5',6a,8a,9-TetraMethyldocosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-4-ol

22-Isoallospirostan-3β-ol

(25R)-5.α.-Spirostan-3.β.-ol

(2aS,4S,5'R,6aS,6bS,8aS,8bR,9S,10R,11aS,12aS,12bR)-5',6a,8a,9-Tetramethyldocosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-4-ol

5α, 20α, 22α, 25D-SPIROSTAN-3β-OL

Sisal saponin

(2aS,4S,5'R,6aS,6bS,8aS,8bR,9S,10R,11aS,12aS,12bR)-5',6a,8a,9-Tetramethyldocosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-4-ol

77-60-1

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