METHYL 3-(DIMETHYLAMINO)PROPIONATE

METHYL 3-(DIMETHYLAMINO)PROPIONATE Property

Melting point:

120.5-121.0 °C

Boiling point:

152-154 °C (lit.)

Density 

0.917 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.418(lit.)

Flash point:

124 °F

storage temp. 

2-8°C

form 

liquid

pka

8.25±0.28(Predicted)

color 

colorless

Safety

Hazard Codes 

Xi

Risk Statements 

10-36/37/38

Safety Statements 

16-26-36/37/39

RIDADR 

UN 3272 3/PG 3

WGK Germany 

3

RTECS 

AY5992870

HazardClass 

3.2

PackingGroup 

III

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

METHYL 3-(DIMETHYLAMINO)PROPIONATE Chemical Properties,Usage,Production

Uses

Methyl 3-(dimethylamino)propionate was used in the synthesis of lithium enolate via reaction with lithium diisopropylamide.

Preparation

Methyl 3-(Dimethylamino)propionate can be obtained by the reaction of methyl acrylate with dimethylamine in ether at 0-25 °C^[1].

General Description

Methyl 3-(Dimethylamino)propionate is an organic synthetic reagent used for the preparation of α-methylene esters, acids and lactones.

storage

Methyl 3-(dimethylamino)propionate exhibits typical tendency of amines to undergo slow oxidation in the air. Use in a fume hood.

References

1. Rouvier, E.; Giacomoni, J.-C.; Cambon, A. BSF 1971, 1717.