5-Bromo-7-azaindole

ChemicalBook > CAS DataBase List > 5-Bromo-7-azaindole

Product Name: 5-Bromo-7-azaindole
CAS No.: 183208-35-7
Chemical Name: 5-Bromo-7-azaindole
Synonyms: 5-BROMO-1H-PYRROLO[2,3-B]PYRIDINE;3-Bromo-7H-pyrrolo[2,3-b]pyridine;SW-57;SWF-57;SKL277;EOS-60661;5-BROMO AZAINDOLE;5-bromo-7-azindole;5-BROMO-7-AZAINDOLE;5-Bromo-7-azaindole,96%
CBNumber: CB6756981
Molecular Formula: C7H5BrN2
Formula Weight: 197.03
MOL File: 183208-35-7.mol

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5-Bromo-7-azaindole Property

Melting point:: 176-180 °C
Boiling point:: 357.4±42.0 °C(Predicted)
Density: 1.79±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 6.25±0.20(Predicted)
form: Crystalline Powder
color: White to yellow
InChI: InChI=1S/C7H5BrN2/c8-6-3-5-1-2-9-7(5)10-4-6/h1-4H,(H,9,10)
InChIKey: LPTVWZSQAIDCEB-UHFFFAOYSA-N
SMILES: C12NC=CC1=CC(Br)=CN=2
LogP: 1.8 at 25℃ and pH7
CAS DataBase Reference: 183208-35-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22-41
Safety Statements: 26-39
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 692549
Product name: 5-Bromo-7-azaindole
Purity: 97%
Packaging: 5g
Price: $200
Updated: 2024/03/01

Sigma-Aldrich

Product number: 692549
Product name: 5-Bromo-7-azaindole
Purity: 97%
Packaging: 1g
Price: $49.9
Updated: 2023/06/20

TCI Chemical

Product number: B3588
Product name: 5-Bromo-1H-pyrrolo[2,3-b]pyridine
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $39
Updated: 2024/03/01

TCI Chemical

Product number: B3588
Product name: 5-Bromo-1H-pyrrolo[2,3-b]pyridine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $117
Updated: 2024/03/01

Alfa Aesar

Product number: H50040
Product name: 5-Bromo-7-azaindole, 96%
Packaging: 1g
Price: $52.65
Updated: 2024/03/01

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5-Bromo-7-azaindole Chemical Properties,Usage,Production

Chemical Properties

White to light brown powder or crystal

Uses

5-Bromo-7-azaindole is a chemical reagent used in organic syntheses. Used in the synthesis of Venetoclax (A112430), a potent and selective BCL-2 inhibitor that achieves potent antitumour activity while sparing platelets. Also used in other 7-azaindole derivatives such as for PDK1 inihibtors.

Synthesis

In the 250 ml flask is sequentially added in 50 ml ethanol and 5-bromo-1-hydrogen pyrrolo [2,3 - the b] pyridine -2 - ketone (4.2g, 20 mmol), Sn powder (4.7 g, 40 mmol) and 5 mol/L hydrochloric acid (14 ml), 40 ℃ stirring for 2 hours, the reaction is completed, to remove the ethanol, add 50 ml of water residue is completely dissolved, saturated NaHCO3 solution and to pH=8, and filtering the resulting solid, after drying, dissolved in 50 ml chloroform, adding CuBr2(13.4 g, 60mmol), 60 Cstirring for 2 hours, the reaction is completed, the end of the reaction, rotary evaporated to remove chloroform, adding 50 ml saturated NaHCO3 solution, ethyl acetate (3 × 100 ml), the combined organic phase with water (50 ml) for washing and then the saturated salt water (50 ml) washing, anhydrous Na2SO4 drying, filtering, the filtrate is concentrated to obtain 5-bromo-1H-pyrrolo [2,3 - the b] pyridine the crude product, the crude product is chloroform: hexane=2:1 (volume ratio) mixed solution recrystallize to get 3.1 g of pale yellow 5-Bromo-7-azaindole pure product, yield 77.6%, melting point:176.8-177.3 ℃.

Solubility in organics

The solubility of 5-Bromo-7-azaindole in pure solvents increases with increasing temperature. Among them 5-Bromo-7-azaindole showed the best solubility in methyl acetate and the worst solubility in hexane. The maximum change in solubility of 5-Bromo-7-azaindole in DCM was observed at T = 298.15-313.15 K. The solubility of 5-Bromo-7-azaindole in DCM was found to be the most variable.

5-Bromo-7-azaindole Preparation Products And Raw materials

Raw materials

ZINC 7-Azaindole tert-Butanol Boron trifluoride diethyl etherate Government regulation Acetic acid Manganese triacetate dihydrate

Preparation Products

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View Lastest Price from 5-Bromo-7-azaindole manufacturers

Watson Biotechnology Co.,Ltd

Product: 5-Bromo-7-azaindole 183208-35-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20MT
Release date: 2024-09-21

Jinan Finer Chemical Co., Ltd

Product: 5-Bromo-7-azaindole 183208-35-7
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20mt
Release date: 2019-03-19

Wuhan Circle Star Chem-medical Technology Co.,Ltd

Product: 5-Bromo-7-azaindole 183208-35-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 1000
Release date: 2024-12-19

183208-35-7, 5-Bromo-7-azaindoleRelated Search:

Indole-3-butyric acid 1-(2,6-Dichlorophenyl)indolin-2-one 7-Azaindole N-Methyl-2-pyrrolidone Indometacin N-Vinyl-2-pyrrolidone Pyrrolidine Polyvinylpyrrolidone Pyridine Indole-3-acetic acid 5-BROMO-1H-PYRROLO[2,3-C]PYRIDIN-2(3H)-ONE tert-butyl 4-(4-broMothiazol-2-yl)piperazine-1-carboxylate (6-Methylpyridazin-3-yl)MethanaMine dihydrochloride No Chinese name rac-4-(6-chloro-2-oxo-2,3-dihydro-1H-indol-3-yl)-piperidine-1-carboxylic acid tert-butyl 5-METHYL-4,5,6,7-TETRAHYDRO[1,3]THIAZOLO[5,4-C]PYRIDIN-2-AMINE 1-METHYL-5-NITRO-1H-INDAZOLE 2,4-dichloro-7H-Pyrrolo[2,3-d]pyriMidine-7-carboxylic acid 1,1-diMethylethyl ester

5-BROMO-1H-PYRROLO[2,3-B]PYRIDINE

5-BROMO-7-AZAINDOLE

5-Bromo-7-azaindole,96%

5-BROMO AZAINDOLE

1H-Pyrrolo[2,3-b]pyridine, 5-bromo-

5-Bromo-1H-pyrrolo2,3-büpyridine

5-Bromo-1H-pyrrolo[2,3-b]pyridine ,97%

5-Bromo-7-azaindole 97%

3-Bromo-7H-pyrrolo[2,3-b]pyridine

5-BroMo-7-azaindole, 97+%

5-Bromo-1H-pyrrolo[2,3-β]pyridine

5-Bromo-7-azaindole≥ 99% (HPLC)

EOS-60661

5-Bromo-7-azaindole ISO 9001：2015 REACH

SWF-57

SW-57

SKL277

5-BROMO-7-AZAINDOLE (5-BROMO-1H-PYRROLO(2,3-b) PYRIDINE

Professional Supply API 5-Bromo-7-Azaindole CAS 183208-35-7

5-bromo-7-azindole

5-BROMO-7-AZAINDOLE / 5-bromo-1H-pyrrolo[2,3-b]pyridine / Venetoclax Intermediate

183208-35-7

183208-35-9

183208-15-7

Intermediate

CHIRAL CHEMICALS

pyridine

Non-Chiral heterocyclic compounds

Heterocycle-Indole series

Heterocycle-Pyridine series

Heterocycles