ChemicalBook > CAS DataBase List > (R)-Phenylephrine Hydrochlorid

(R)-Phenylephrine Hydrochlorid

Product Name
(R)-Phenylephrine Hydrochlorid
CAS No.
61-76-7
Chemical Name
(R)-Phenylephrine Hydrochlorid
Synonyms
PHENYLEPHRINE HCL;PHENYLEPHRINE HYDROCHLORIDE;Phenylephrine Hydrochlorid;(R)-(-)-PHENYLEPHRINE HYDROCHLORIDE;Phenylephrine hydrochloride CRS;L(-)-PHENYLEPHRINE HYDROCHLORIDE;3-Hydroxy-alpha-(methylaminomethyl)benzyl alcohol;uri;fenox;efricel
CBNumber
CB6762113
Molecular Formula
C9H13NO2.ClH
Formula Weight
203.67
MOL File
61-76-7.mol
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(R)-Phenylephrine Hydrochlorid Property

Melting point:
143-145 °C(lit.)
alpha 
-47 º (c=2, H2O)
refractive index 
-45.5 ° (C=1, H2O)
Flash point:
9℃
storage temp. 
2-8°C
solubility 
Freely soluble in water and in ethanol (96 per cent).
form 
Crystalline Powder
pka
pK1 8.77; pK2 9.84(at 25℃)
color 
White to almost white
PH
pH (10g/L, 25℃) : 4.5～5.5
Water Solubility 
>=10 g/100 mL at 21 ºC
Merck 
14,7286
BRN 
4158948
Stability:
Hygroscopic
LogP
-0.310
CAS DataBase Reference
61-76-7(CAS DataBase Reference)
EPA Substance Registry System
Phenylephrine hydrochloride (61-76-7)
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Safety

Hazard Codes 
Xn,T,F
Risk Statements 
22-36/37/38-39/23/24/25-23/24/25-11
Safety Statements 
26-36-37/39-45-36/37-16-7
RIDADR 
3249
WGK Germany 
3
RTECS 
DO7525000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29225090
Toxicity
LD50 in rats (mg/kg): 17 ±1.1 i.p.; 33 ±2.0 s.c. (Warren, Werner)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P8155
Product name
(R)-(−)-Phenylephrine hydrochloride
Purity
analytical standard
Packaging
1vial
Price
$64.8
Updated
2024/03/01
Sigma-Aldrich
Product number
P-078
Product name
R-(-)-Phenylephrine hydrochloride solution
Purity
1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant?
Packaging
1mL
Price
$98.5
Updated
2024/03/01
Sigma-Aldrich
Product number
BP284
Product name
Phenylephrine hydrochloride
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
100MG
Price
$255
Updated
2024/03/01
Sigma-Aldrich
Product number
1533002
Product name
Phenylephrine hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$436
Updated
2024/03/01
TCI Chemical
Product number
P0398
Product name
(R)-Phenylephrine Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$57
Updated
2024/03/01
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(R)-Phenylephrine Hydrochlorid Chemical Properties,Usage,Production

Description

R-(-)-Phenylephrine is an adrenergic α1A receptor agonist (Ki = 1.4 μM) that demonstrates selectivity against the α1B and α1C receptor subtypes (Kis = 23.9 and 47.8 μM, respectively). By stimulating adrenergic α1 receptors, L-phenylephrine can induce aortic smooth muscle contractions, although reported relative affinity and potency values in rabbit are 5-fold weaker compared to that of L-norepinephrine . This compound is frequently used to precontract smooth muscle in preparations designed to study the properties of various vasodilator agents.

Chemical Properties

Phenylephrine Hydrochloride is white or nearly white crystalline substance, odorless, bitter taste. Solutions are acid to litmus paper, freely soluble in water and in alcohol. Levorotatory in solution.

Chemical Properties

white to almost white crystalline powder

Originator

Neosynephrine, Badrial, France ,1953

Uses

(R)-Phenylephrine Hydrochloride is an α-Adrenergic agonist. Mydriatic; decongestant.

Uses

Phenylephrine hydrochloride is used medically as a vasoconstrictor and pressor drug. It is chemically related to epinephrine and ephedrine. Actions are usually longer lasting than the latter two drugs. The action of phenylephrine hydrochloride contrasts sharply with epinephrine and ephedrine, in that its action on the heart is to slow the rate and to increase the stroke output, inducing no disturbance in the rhythm of the pulse. In therapeutic doses, it produces little if any stimulation of either the spinal cord or cerebrum. The drug is intended for the maintenance of an adequate level of blood pressure during spinal and inhalation anesthesia and for the treatment of vascular failure in shock, shock-like states, and drug-induced hypotension, or hypersensitivity. It is also used to overcome paroxysmal supraventricular tachycardia, to prolong spinal anesthesia, and as a vasoconstrictor in regional analgesia. Caution is required in the administration of phenylephrine hydrochloride to elderly persons, or to patients with hyperthyroidism, bradycardia, partial heart block, myocardial disease, or severe arteriosclerosis. The brand name Neo-Synephrine? is also used to designate another product (nose drops) which does not contain phenylephrine hydrochloride. The nose drops contain xylometazoline hydrochloride.

Uses

DECONGESTANTS

Definition

ChEBI: A hydrochloride that is the monohydrochloride salt of phenylephrine.

Manufacturing Process

4.5 g of the hydrochloride of m-hydroxymethylaminoacetophenone aredissolved in a small amount of water; to the solution a solution of colloidal palladium obtained from palladiumchloride is added, and the mixture is treated with hydrogen.
After diluting the reaction liquid with acetone it is filtered, and the residue obtained after the evaporation of the filtrate in vacuo, and complete drying over pentoxide of phosphorus is then dissolved in absolute alcohol, and to this is added about the same volume of dry ether, until turbidity just commences to occur. After a short time the hydrochloride of the m-hydroxyphenylethanolmethylamine will separate out as a colorless mass of crystals at a melting point of 142°C to 143°C.

brand name

Afrin 4 Hour Nasal Spray (Schering-Plough Health Care); Biomydrin (Parke-Davis); Mydfrin (Alcon); Neo-Synephrine (Sterling Health U.S.A.); Nostril (Boehringer Ingelheim).

Therapeutic Function

Adrenergic

General Description

Odorless white microcrystalline powder. Bitter taste. pH (1% aqueous solution) about 5.

Air & Water Reactions

May be sensitive to prolonged exposure to air and light. Water soluble.

Reactivity Profile

Phenylephrine hydrochloride is incompatible with acids, acid chlorides, acid anhydrides and oxidizing agents. Phenylephrine hydrochloride is also incompatible with butacaine, alkalis and ferric salts.

Fire Hazard

Flash point data for Phenylephrine hydrochloride are not available; however, Phenylephrine hydrochloride is probably combustible.

Biological Activity

α 1 -adrenoceptor agonist; pK i values are 5.86, 4.87 and 4.70 for α 1D , α 1B and α 1A receptors respectively.

Contact allergens

Phenylephrine hydrochloride is an alpha-adrenergic agonist, used as a mydriatic and decongestant in eyedrops.

Safety Profile

Poison by ingestion, intraperitoneal, subcutaneous, intravenous,and intramuscular routes. Mutation data reported. When heated to decomposition it emits very toxic fumes of HCl and NOx.

Veterinary Drugs and Treatments

Phenylephrine is a vasoconstrictor used to differentiate conjunctival vascular injection (blanches with phenylephrine application) versus deep episcleral injection (blanches incompletely) associated with uveitis, glaucoma, or scleritis. It is also used prior to conjunctival surgery to reduce hemorrhage and in combination with atropine prior to cataract or other intraocular surgeries that require maximal pupillary dilation. Phenylephrine can be used to confirm the diagnosis of Horner’s syndrome. Dilution of 2.5% phenylephrine solution with saline (1:10) produces a 0.25% solution. Normal eyes will not demonstrate mydriasis in response to this low concentration of phenylephrine. Third order Horner’s syndrome of greater than two weeks duration is associated with receptor up regulation and therefore a response to 0.25% phenylephrine is noted. In this way, the diagnosis of Horner’s is confirmed and a suggestion as to whether or not the condition is 2nd or 3rd order in nature.
In dogs, maximum mydriasis persists for about 2 hours and effects may last for up to 18 hours. Phenylephrine has significant alpha adrenergic effects (vasoconstriction and pupillary dilation) and minimal effects on beta receptors. When used alone, phenylephrine is reportedly not efficacious in the cat unless used with other mydriatics.

storage

Desiccate at RT

(R)-Phenylephrine Hydrochlorid Preparation Products And Raw materials

Raw materials

Benzyl alcohol Toluene Bromide Diethyl ether

Preparation Products

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View Lastest Price from (R)-Phenylephrine Hydrochlorid manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Phenylephrine hydrochloride 61-76-7
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
98.0%-102%;USP
Supply Ability
500kg
Release date
2021-06-02
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
(R)-Phenylephrine Hydrochlorid 61-76-7
Price
US $999.00-800.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-08-21
Baoji Guokang Bio-Technology Co., Ltd.
Product
(R)-Phenylephrine Hydrochlorid 61-76-7
Price
US $520.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1-1000kg
Release date
2021-06-07

61-76-7, (R)-Phenylephrine HydrochloridRelated Search:

Ethyl acetate Topotecan hydrochloride Ursodeoxycholic acid Isoprenaline hydrochloride Epinephrine Hydrochloride Benzyl alcohol L(-)-Epinephrine CHLOROPHOSPHONAZO III Chenodeoxycholic acid DL-NORPHENYLEPHRINE HYDROCHLORIDE N-methyl-5,6-dihydroxyindole 2,2-Dichloro-1-(3-hydroxyphenyl)-ethanone N-(2-Succinyl) Phenylephrine Phenylephrine Impurity 32 N-ACETYL-4-BENZOQUINONE IMINE 1,2,3,4-Tetrahydro-4,6-dihydroxy-2-methyl-isoquinoline 3-Hydroxy-4-[[(2R)-2-hydroxy-2-(3-hydroxyphenyl)ethyl]MethylaMino]-4-oxo-butanoic Acid Phenylephrine EP Impurity D Phenylephrine Hcl

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