ChemicalBook > CAS DataBase List > (R)-Phenylephrine Hydrochlorid

(R)-Phenylephrine Hydrochlorid

Product Name
(R)-Phenylephrine Hydrochlorid
CAS No.
61-76-7
Chemical Name
(R)-Phenylephrine Hydrochlorid
Synonyms
PHENYLEPHRINE HCL;PHENYLEPHRINE HYDROCHLORIDE;Phenylephrine Hydrochlorid;(R)-(-)-PHENYLEPHRINE HYDROCHLORIDE;Phenylephrine hydrochloride CRS;L(-)-PHENYLEPHRINE HYDROCHLORIDE;3-Hydroxy-alpha-(methylaminomethyl)benzyl alcohol;uri;fenox;efricel
CBNumber
CB6762113
Molecular Formula
C9H13NO2.ClH
Formula Weight
203.67
MOL File
61-76-7.mol
More
Less

(R)-Phenylephrine Hydrochlorid Property

Melting point:
143-145 °C(lit.)
alpha 
-47 º (c=2, H2O)
refractive index 
-45.5 ° (C=1, H2O)
Flash point:
9℃
storage temp. 
2-8°C
solubility 
Freely soluble in water and in ethanol (96 per cent).
form 
Crystalline Powder
pka
pK1 8.77; pK2 9.84(at 25℃)
color 
White to almost white
PH
pH (10g/L, 25℃) : 4.5~5.5
Water Solubility 
>=10 g/100 mL at 21 ºC
Merck 
14,7286
BRN 
4158948
Stability:
Hygroscopic
LogP
-0.310
CAS DataBase Reference
61-76-7(CAS DataBase Reference)
EPA Substance Registry System
Phenylephrine hydrochloride (61-76-7)
More
Less

Safety

Hazard Codes 
Xn,T,F
Risk Statements 
22-36/37/38-39/23/24/25-23/24/25-11
Safety Statements 
26-36-37/39-45-36/37-16-7
RIDADR 
3249
WGK Germany 
3
RTECS 
DO7525000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29225090
Toxicity
LD50 in rats (mg/kg): 17 ±1.1 i.p.; 33 ±2.0 s.c. (Warren, Werner)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P8155
Product name
(R)-(−)-Phenylephrine hydrochloride
Purity
analytical standard
Packaging
1vial
Price
$64.8
Updated
2024/03/01
Sigma-Aldrich
Product number
P-078
Product name
R-(-)-Phenylephrine hydrochloride solution
Purity
1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant?
Packaging
1mL
Price
$98.5
Updated
2024/03/01
Sigma-Aldrich
Product number
BP284
Product name
Phenylephrine hydrochloride
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
100MG
Price
$255
Updated
2024/03/01
Sigma-Aldrich
Product number
1533002
Product name
Phenylephrine hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$436
Updated
2024/03/01
TCI Chemical
Product number
P0398
Product name
(R)-Phenylephrine Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$57
Updated
2024/03/01
More
Less

(R)-Phenylephrine Hydrochlorid Chemical Properties,Usage,Production

Description

R-(-)-Phenylephrine is an adrenergic α1A receptor agonist (Ki = 1.4 μM) that demonstrates selectivity against the α1B and α1C receptor subtypes (Kis = 23.9 and 47.8 μM, respectively). By stimulating adrenergic α1 receptors, L-phenylephrine can induce aortic smooth muscle contractions, although reported relative affinity and potency values in rabbit are 5-fold weaker compared to that of L-norepinephrine . This compound is frequently used to precontract smooth muscle in preparations designed to study the properties of various vasodilator agents.

Chemical Properties

Phenylephrine Hydrochloride is white or nearly white crystalline substance, odorless, bitter taste. Solutions are acid to litmus paper, freely soluble in water and in alcohol. Levorotatory in solution.

Chemical Properties

white to almost white crystalline powder

Originator

Neosynephrine, Badrial, France ,1953

Uses

(R)-Phenylephrine Hydrochloride is an α-Adrenergic agonist. Mydriatic; decongestant.

Uses

Phenylephrine hydrochloride is used medically as a vasoconstrictor and pressor drug. It is chemically related to epinephrine and ephedrine. Actions are usually longer lasting than the latter two drugs. The action of phenylephrine hydrochloride contrasts sharply with epinephrine and ephedrine, in that its action on the heart is to slow the rate and to increase the stroke output, inducing no disturbance in the rhythm of the pulse. In therapeutic doses, it produces little if any stimulation of either the spinal cord or cerebrum. The drug is intended for the maintenance of an adequate level of blood pressure during spinal and inhalation anesthesia and for the treatment of vascular failure in shock, shock-like states, and drug-induced hypotension, or hypersensitivity. It is also used to overcome paroxysmal supraventricular tachycardia, to prolong spinal anesthesia, and as a vasoconstrictor in regional analgesia. Caution is required in the administration of phenylephrine hydrochloride to elderly persons, or to patients with hyperthyroidism, bradycardia, partial heart block, myocardial disease, or severe arteriosclerosis. The brand name Neo-Synephrine? is also used to designate another product (nose drops) which does not contain phenylephrine hydrochloride. The nose drops contain xylometazoline hydrochloride.

Uses

DECONGESTANTS

Definition

ChEBI: A hydrochloride that is the monohydrochloride salt of phenylephrine.

Manufacturing Process

4.5 g of the hydrochloride of m-hydroxymethylaminoacetophenone aredissolved in a small amount of water; to the solution a solution of colloidal palladium obtained from palladiumchloride is added, and the mixture is treated with hydrogen.
After diluting the reaction liquid with acetone it is filtered, and the residue obtained after the evaporation of the filtrate in vacuo, and complete drying over pentoxide of phosphorus is then dissolved in absolute alcohol, and to this is added about the same volume of dry ether, until turbidity just commences to occur. After a short time the hydrochloride of the m-hydroxyphenylethanolmethylamine will separate out as a colorless mass of crystals at a melting point of 142°C to 143°C.

brand name

Afrin 4 Hour Nasal Spray (Schering-Plough Health Care); Biomydrin (Parke-Davis); Mydfrin (Alcon); Neo-Synephrine (Sterling Health U.S.A.); Nostril (Boehringer Ingelheim).

Therapeutic Function

Adrenergic

General Description

Odorless white microcrystalline powder. Bitter taste. pH (1% aqueous solution) about 5.

Air & Water Reactions

May be sensitive to prolonged exposure to air and light. Water soluble.

Reactivity Profile

Phenylephrine hydrochloride is incompatible with acids, acid chlorides, acid anhydrides and oxidizing agents. Phenylephrine hydrochloride is also incompatible with butacaine, alkalis and ferric salts.

Fire Hazard

Flash point data for Phenylephrine hydrochloride are not available; however, Phenylephrine hydrochloride is probably combustible.

Biological Activity

α 1 -adrenoceptor agonist; pK i values are 5.86, 4.87 and 4.70 for α 1D , α 1B and α 1A receptors respectively.

Contact allergens

Phenylephrine hydrochloride is an alpha-adrenergic agonist, used as a mydriatic and decongestant in eyedrops.

Safety Profile

Poison by ingestion, intraperitoneal, subcutaneous, intravenous,and intramuscular routes. Mutation data reported. When heated to decomposition it emits very toxic fumes of HCl and NOx.

Veterinary Drugs and Treatments

Phenylephrine is a vasoconstrictor used to differentiate conjunctival vascular injection (blanches with phenylephrine application) versus deep episcleral injection (blanches incompletely) associated with uveitis, glaucoma, or scleritis. It is also used prior to conjunctival surgery to reduce hemorrhage and in combination with atropine prior to cataract or other intraocular surgeries that require maximal pupillary dilation. Phenylephrine can be used to confirm the diagnosis of Horner’s syndrome. Dilution of 2.5% phenylephrine solution with saline (1:10) produces a 0.25% solution. Normal eyes will not demonstrate mydriasis in response to this low concentration of phenylephrine. Third order Horner’s syndrome of greater than two weeks duration is associated with receptor up regulation and therefore a response to 0.25% phenylephrine is noted. In this way, the diagnosis of Horner’s is confirmed and a suggestion as to whether or not the condition is 2nd or 3rd order in nature.
In dogs, maximum mydriasis persists for about 2 hours and effects may last for up to 18 hours. Phenylephrine has significant alpha adrenergic effects (vasoconstriction and pupillary dilation) and minimal effects on beta receptors. When used alone, phenylephrine is reportedly not efficacious in the cat unless used with other mydriatics.

storage

Desiccate at RT

(R)-Phenylephrine Hydrochlorid Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

(R)-Phenylephrine Hydrochlorid Suppliers

Clearsynth Labs Limited
Tel
+91-22-26355700
Fax
+91-22-26355701
Email
info@clearsynth.com
Country
India
ProdList
9679
Advantage
58
Jai Radhe Sales
Tel
+(91)-(79)-26431096/65255722
Fax
+(91)-(79)-26569884
Email
info@jairadhesales.com
Country
India
ProdList
397
Advantage
60
TCI Chemicals (India) Pvt. Ltd.
Tel
--
Fax
--
Email
sales-in@tcichemicals.com
Country
India
ProdList
6768
Advantage
58
Mulberry Chemicals Pvt. Ltd.
Tel
--
Fax
--
Email
mulberrychemicals@gmail.com
Country
India
ProdList
3
Advantage
0
Manus Aktteva
Tel
--
Fax
--
Email
info@manusaktteva.in
Country
India
ProdList
581
Advantage
34
Alfa Aesar
Tel
--
Fax
--
Email
tech@alfa.com
Country
India
ProdList
6905
Advantage
58
Indosol Exports
Tel
--
Fax
--
Country
India
ProdList
61
Advantage
58
Alkali Metals Ltd.
Tel
--
Fax
--
Email
lkalimetals@alkalimetals.com
Country
India
ProdList
286
Advantage
58
Pharma Affiliates
Tel
--
Fax
--
Email
@pharmaffiliates.com
Country
India
ProdList
6754
Advantage
58
Bazayan & Co.
Tel
--
Fax
--
Email
info@bazayan.ch
Country
India
ProdList
150
Advantage
58
Clearsynth Labs
Tel
--
Fax
--
Email
fo@clearsynth.com
Country
India
ProdList
3887
Advantage
58
Avience chemicals and pharmaceuticals
Tel
--
Fax
--
Email
expoavience@gmail.com
Country
India
ProdList
180
Advantage
58
Vervain Pharm Chem
Tel
--
Fax
--
Email
export@vervain.co.in
Country
India
ProdList
139
Advantage
58
Unimax Chemicals Pvt. Ltd.
Tel
--
Fax
--
Email
info@unimax.co.in
Country
India
ProdList
39
Advantage
58
Shreeji Pharma International
Tel
--
Fax
--
Country
India
ProdList
166
Advantage
58
Diwa Innovations Pvt., Ltd.
Tel
--
Fax
--
Email
diwa.innovations@gmail.com
Country
India
ProdList
20
Advantage
58
Harsh Pharmachem
Tel
--
Fax
--
Email
harshpharmachem@gmail.com
Country
India
ProdList
39
Advantage
58
Oceanic Pharmachem Pvt., Ltd. (OPPL)
Tel
--
Fax
--
Email
info@oceanicpharmachem.com
Country
India
ProdList
946
Advantage
58
Divis Laboratories Ltd.
Tel
--
Fax
--
Country
India
ProdList
147
Advantage
58
Siddharth International
Tel
--
Fax
--
Country
India
ProdList
107
Advantage
58
Pradipkumar Pharma Pvt., Ltd.
Tel
--
Fax
--
Email
pradipkumar@vsnl.com
Country
India
ProdList
48
Advantage
58
Sneha Medicare Pvt. Ltd.
Tel
--
Fax
--
Email
info@snehamedicare.com
Country
India
ProdList
60
Advantage
58
Heer Pharma Pvt., Ltd.
Tel
--
Fax
--
Email
marketing@heerpharma.com
Country
India
ProdList
31
Advantage
58
Aadivighnesh Chem Private Ltd.
Tel
--
Fax
--
Email
sales@aadivighnesh.com
Country
India
ProdList
119
Advantage
58
Maas Pharma Chemicals
Tel
--
Fax
--
Email
info@maaspharmachemicals.com
Country
India
ProdList
1607
Advantage
58
Unichem Laboratories Ltd.
Tel
--
Fax
--
Email
pankaj.manjrekar@unichemlabs.com
Country
India
ProdList
35
Advantage
58
Chemicals (India) Company
Tel
--
Fax
--
Email
cic@vsnl.com
Country
India
ProdList
28
Advantage
58
Innorex Pharmaceuticals Private Limited
Tel
--
Fax
--
Email
info@innorexpharma.com
Country
India
ProdList
173
Advantage
58
Gayatri Industries.
Tel
--
Fax
--
Email
gayatriindustries23@gmail.com
Country
India
ProdList
103
Advantage
58
Aster International Pharmaceuticals LLP
Tel
--
Fax
--
Email
info@asterintl.com
Country
India
ProdList
113
Advantage
58
Festiva Pharma
Tel
--
Fax
--
Country
India
ProdList
237
Advantage
58
Synthetic Molecules Pvt Ltd (SMPL)
Tel
--
Fax
--
Email
info@syntheticmolecules.com
Country
India
ProdList
20
Advantage
58
Vadivarhe Speciality Chemicals Ltd.
Tel
--
Fax
--
Email
sales@vscl.co.in
Country
India
ProdList
10
Advantage
58
Griffith Overseas Pvt. Ltd.
Tel
--
Fax
--
Email
sourcing@griffithoverseas.com
Country
India
ProdList
46
Advantage
58
Novas International
Tel
--
Fax
--
Email
info@novasinternational.com
Country
India
ProdList
210
Advantage
58
Ralington Pharma
Tel
--
Fax
--
Email
info@ralingtonpharma.com
Country
India
ProdList
312
Advantage
58
G.C Chemie Pharmie Ltd.
Tel
--
Fax
--
Email
info@gccpl.com
Country
India
ProdList
42
Advantage
58
Atlas Life Sciences Pvt. Ltd.
Tel
--
Fax
--
Email
contact@atlaslifesciences.com
Country
India
ProdList
2
Advantage
58
Rawia International HealthCare Pvt. Ltd.
Tel
--
Fax
--
Email
info@rawia.in
Country
India
ProdList
170
Advantage
58
HY-GRO CHEMICALS PHARMTEK PRIVATE LIMITED
Tel
--
Fax
--
Email
hygro@hygrochemicals.com
Country
India
ProdList
10
Advantage
58
Opulent Pharma
Tel
--
Fax
--
Country
India
ProdList
810
Advantage
58
Chempro Pharma Pvt. Ltd.
Tel
--
Fax
--
Email
ankitsehgal@chemprogroup.net
Country
India
ProdList
170
Advantage
58
SHILPA MEDICARE LTD
Tel
--
Fax
--
Email
info@vbshilpa.com
Country
India
ProdList
52
Advantage
58
Shree Raj Chem
Tel
--
Fax
--
Country
India
ProdList
91
Advantage
58
Gradient Exports
Tel
--
Fax
--
Email
admin@gradientexports.com
Country
India
ProdList
77
Advantage
58
Eppion Lifesciences
Tel
--
Fax
--
Email
contact@eppionlifesciences.in
Country
India
ProdList
103
Advantage
58
Eastern Chemicals (Mumbai) Pvt., Ltd.
Tel
--
Fax
--
Email
info@ecmpl.com
Country
India
ProdList
104
Advantage
58
Sibram Pharmaceutical
Tel
--
Fax
--
Email
contact@sibram.com
Country
India
ProdList
136
Advantage
58
Aadish Impex Private Limited
Tel
--
Fax
--
Email
info@aadishimpex.com
Country
India
ProdList
89
Advantage
58
Pharmchem
Tel
--
Fax
--
Email
nipun@phrmchem.net
Country
India
ProdList
38
Advantage
58
More
Less

View Lastest Price from (R)-Phenylephrine Hydrochlorid manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Phenylephrine hydrochloride 61-76-7
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
98.0%-102%;USP
Supply Ability
500kg
Release date
2021-06-02
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
(R)-Phenylephrine Hydrochlorid 61-76-7
Price
US $999.00-800.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-08-21
airuikechemical co., ltd.
Product
Phenylephrine hydrochloride 61-76-7
Price
US $0.00-0.00/g
Min. Order
1g
Purity
99.9%
Supply Ability
20 tons
Release date
2024-04-03

61-76-7, (R)-Phenylephrine HydrochloridRelated Search:


  • (-)-3-[1(R)-Hydroxy-2-(methylamino)ethyl]phenol hydrochloride
  • Phenylephrine Hydrochloride (200 mg)
  • PHENYLEPHRINE HCL BP ((R)-3-HYDROXY-ALPHA-(METHYLAMINO) METHYL] BENZENEMETHANOLHYDROCHL ORIDE)
  • (-)-3-HYDROXY-ALPHA-(METHYLAMINOMETHYL)BENZYL ALCOHOL HYDROCHLORIDE
  • L-1-(M-HYDROXYPHENYL)-2-METHYLAMINOETHANOL HYDROCHLORIDE
  • L-(3-HYDROXYPHENYL)-N-METHYLETHANOLAMINEHYDROCHLORIDE
  • L-A-HYDROXY-B-METHYLAMINO-3-HYDROXY-1-ETHYLBENZENE HYDROCHLORIDE
  • L(-)-PHENYLEPHRINE HCL
  • L-PHENYLEPHRINE HCL
  • L(-)-PHENYLEPHRINE HYDROCHLORIDE
  • L-PHENYLEPHRINE HYDROCHLORIDE
  • L-M-HYDROXY-A-[(METHYLAMINO)METHYL]BENZYL ALCOHOL HYDROCHLORIDE
  • (<i>R</i>)-Phenylephrine hydrochloride
  • (R)-3-(1-hydroxy-2-(MethylaMino)ethyl)phenol hydrochloride
  • BenzeneMethanol, 3-hydroxy-α-[(MethylaMino)Methyl]-,hydrochloride (1:1), (aR)-
  • (αR)-3-hydroxy-α-[(methylamino)methyl]-benzenemethanol, hydrochloride (1:1)
  • R(-)-Phenylephrine hydrochloride solution
  • Phenylephrine Impurity 7
  • M-METHYLAMINOETHANOLPHENOL HYDROCHLORIDE
  • PHENYLEPHRINE HCL
  • (-)-PHENYLEPHRINE HYDROCHLORIDE
  • PHENYLEPHRINE HYDROCHLORIDE
  • Phenylephrine Hydrochloride (125 mg)
  • Phenylephrine hydroc
  • Phenylephrine-d3 hydrochloride
  • 3-(1-hydroxy-2-(MethylaMino)ethyl)phenol HCl
  • N-(2,2-dichloro-1-cyano-vinyl)-4-Methyl-benzaMide
  • L(-)-Phenylephrine hydrochloride, 99% 10GR
  • (-)-M-Hydroxy-α-[(MethylaMino)Methyl]benzyl Alcohol Hydrochloride
  • (αR)-3-Hydroxy-α-[(MethylaMino)Methyl]benzeneMethanol Hydrochloride
  • Levophenylephrine Hydrochloride
  • (-)-alpha-hydroxy-beta-(methylamino)ethyl-alpha-(3-hydroxybenzene)hydrochlor
  • 1-m-hydroxy-alpha-(methylaminomethyl)benzylalcoholhydrochloride
  • 3-hydroxy-alpha-((methylamino)methyl)-,hydrochloride,(-)-benzenemethano
  • almefrin
  • benzenemethanol,3-hydroxy-alpha-[(methylamino)methyl]-,hydrochloride,(thet
  • consdrin
  • consdrinhydrochloride
  • d-(-)-phenylephrinehydrochloride
  • efricel
  • emagrin
  • fenilfar
  • fenox
  • histabid
  • idrianol
  • isophrinehydrochloride
  • isophrinhydrochloride
  • lexatol
  • meta-synephrinehydrochloride
  • metroxedrine
  • nci-c55641
  • neooxedrinechloride
  • neosympatol
  • neosynephrinehydrochloride
  • neo-synesin1
  • oftalfrine
  • op-isophrin
  • phenistan