3-(4-IODOPHENYL)-2-MERCAPTO-(Z)-2-PROPENOIC ACID

ChemicalBook > CAS DataBase List > 3-(4-IODOPHENYL)-2-MERCAPTO-(Z)-2-PROPENOIC ACID

3-(4-IODOPHENYL)-2-MERCAPTO-(Z)-2-PROPENOIC ACID

Product Name: 3-(4-IODOPHENYL)-2-MERCAPTO-(Z)-2-PROPENOIC ACID
CAS No.: 179528-45-1
Chemical Name: 3-(4-IODOPHENYL)-2-MERCAPTO-(Z)-2-PROPENOIC ACID
Synonyms: CS-2366;PD 150606;PD150606 (PD 150606;PD150606;PD-150606;PD 150606;(Z)-3-(4-iodophenyl)-2-mercaptoacrylic acid;(Z)-3-(4-Iodophenyl)-2-mercapto-2-propenoic acid;3-(4-IODOPHENYL)-2-MERCAPTO-(Z)-2-PROPENOIC ACID;(Z)-3-(4-IODOPHENYL)-2-SULFANYLPROP-2-ENOIC ACID;(2Z)-3-(4-iodophenyl)-2-mercapto-2-Propenoic acid;(2Z)-3-(4-iodophenyl)-2-sulfanylprop-2-enoic acid
CBNumber: CB6767143
Molecular Formula: C9H7IO2S
Formula Weight: 306.12
MOL File: Mol file

Less

3-(4-IODOPHENYL)-2-MERCAPTO-(Z)-2-PROPENOIC ACID Property

Boiling point:: 410.4±45.0 °C(Predicted)
Density: 1.901±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: >20mg/mL
form: powder
pka: 2.98±0.10(Predicted)
color: yellowish
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

Less

Safety

Hazard Codes: T
Risk Statements: 25-37/38-41-43
Safety Statements: 26-36/37/39-45
RIDADR: UN 2811 6.1 / PGIII

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H317May cause an allergic skin reaction

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D5946
Product name: PD 150606
Purity: ≥97% (HPLC)
Packaging: 5mg
Price: $127
Updated: 2024/03/01

Sigma-Aldrich

Product number: D5946
Product name: PD 150606
Purity: ≥97% (HPLC)
Packaging: 25mg
Price: $505
Updated: 2024/03/01

Cayman Chemical

Product number: 13859
Product name: PD 150606
Purity: ≥98%
Packaging: 5mg
Price: $85
Updated: 2024/03/01

Cayman Chemical

Product number: 13859
Product name: PD 150606
Purity: ≥98%
Packaging: 25mg
Price: $332
Updated: 2024/03/01

Tocris

Product number: 1269
Product name: PD 150606
Purity: ≥95%(HPLC)
Packaging: 10
Price: $173
Updated: 2021/12/16

Less

3-(4-IODOPHENYL)-2-MERCAPTO-(Z)-2-PROPENOIC ACID Chemical Properties,Usage,Production

Description

PD-150606 (179528-45-1) is a selective, cell-permeable non-peptide calpain inhibitor (Ki for μ- and m-calpains = 0.21 and 0.37 μM respectively). Acts at the calcium binding site of calpain rather than the substrate-binding site. Inhibits calpain activity in two intact cell systems. Attenuates hypoxic/hypoglycemic injury to cerebrocortical neurons in culture and excitotoxic injury to Purkinje cells in cerebellar slices.1 PD-150606 displays cytoprotective effects in oxidant- and calcium ionophore-induced cell death.2 Some protective effects may be due to inhibition of MMP activity.3

Uses

PD 150606 is a novel mercaptoacrylate based compound and a potent inhibitor of Ca2+-dependent activation of calpain-1, a Ca2+-activated cytosolic cysteine protease. PD 150606 may potentially be developed as an anti-inflammatory agent. Neuroprotective product.

Definition

ChEBI: An organoiodine compound that is acrylic acid in which the vinylic hydrogens at positions 2 and 3 are replaced by mercapto and 4-iodophenyl groups respectively (the Z geoisomer).

Biochem/physiol Actions

PD 150606 is a selective; cell-permeable; non-peptide; uncompetitive calpain inhibitor.

storage

Store at -20°C

References

1) Wang?et al. (1996),?An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective; Proc. Natl. Acad. Sci. USA,?93?6687 2) Waters?et al. (1997),?Calpains mediate calcium and chloride influx during the late phase of cell injury; J. Pharmacol. Exp. Therap.,?283?1177 3) Ali?et al. (2012), Calpain inhibitors exhibit matrix metalloproteinase-2 inhibitory activity; Biochem. Biophys. Res. Commun.,?423?1

3-(4-IODOPHENYL)-2-MERCAPTO-(Z)-2-PROPENOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

Less

3-(4-IODOPHENYL)-2-MERCAPTO-(Z)-2-PROPENOIC ACID Suppliers

Canada 1 China 79 India 1 Japan 1 Switzerland 1 United Kingdom 3 United States 18 Global 104

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Shanghai TaoSu Biochemical Technology Co., Ltd.

Tel: 021-33632979
Fax: 021-34692979
Email: info@tsbiochem.com
Country: China
ProdList: 8065
Advantage: 58

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2990
Advantage: 60

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51456
Advantage: 80

Tongling HengYou Biotechnology Co., Ltd.

Tel: 021-50426030 13856289449
Fax: 021-50426030
Email: 2630597085@qq.com
Country: China
ProdList: 1889
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

Shanghai SuperLan Chemcial Technique Centre

Tel: 021-2022843681 15618226720
Fax: +86-21-51601218
Email: lucy@atkchemical.com
Country: China
ProdList: 10285
Advantage: 58

Angel Pharmatech, Ltd.

Tel: 17317130613
Fax: QQ3358272972
Email: 3358272972@qq.com
Country: China
ProdList: 3251
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57412
Advantage: 58

Hefei Hirisun Pharmatech Co., Ltd

Tel: +8615056975894
Fax: 86-0551-62678551
Email: shawn@hirisunpharm.com
Country: CHINA
ProdList: 9911
Advantage: 58

HANGZHOU CLAP TECHNOLOGY CO.,LTD

Tel: 86-571-88216897,88216896 13588875226
Fax: 86-571-88216895
Email: sales@hzclap.com
Country: CHINA
ProdList: 6312
Advantage: 58

DC Chemicals

Tel: 021-58447131 13564518121
Email: sales@dcchemicals.com
Country: China
ProdList: 9409
Advantage: 58

Shanghai Jiange Chemical Co., Ltd.

Tel: 15921040873
Email: 1434142450@qq.com
Country: CHINA
ProdList: 7649
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11217
Advantage: 58

Shanghai Zeye Biotechnology Co., Ltd.

Tel: 021-61998551 13122364865
Email: sale1@shzysw.net
Country: China
ProdList: 9772
Advantage: 58

Shanghai hongqu biomedical technology co. LTD

Tel: 88888888888
Email: hongquchem@qq.com
Country: China
ProdList: 5132
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

Zhengzhou convergence chemical co., LTD

Tel: 0371-0371-55153829 18003835034
Fax: 18003835034（微信）
Email: 2853979819@qq.com
Country: China
ProdList: 9718
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29774
Advantage: 58

Kaifeng Mingren Pharmaceutical Co.,LTD

Tel: 0371-65741762
Fax: QQ：2860768577
Email: sales@hasunny.com
Country: China
ProdList: 2380
Advantage: 58

InvivoChem

Tel: 13549236410
Email: sales@invivochem.cn
Country: China
ProdList: 6753
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24647
Advantage: 58

Baoji Didu Pharmaceutical and Chemical Co., Ltd

Tel: 02961856358 15829046862
Email: 1035@dideu.com
Country: China
ProdList: 10010
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: cindy.huang@synzest.com
Country: China
ProdList: 12005
Advantage: 58

RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
ProdList: 9272
Advantage: 58

ATK CHEMICAL COMPANY LIMITED

Tel: +undefined-21-51877795
Fax: +86 21 5161 9052/ 5187 7796
Email: ivan@atkchemical.com
Country: China
ProdList: 32957
Advantage: 60

Hangzhou MolCore BioPharmatech Co.,Ltd.

Tel: +86-057181025280; +8617767106207
Fax: 0571-85806285
Email: sales@molcore.com
Country: China
ProdList: 49734
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

Shanghai Haoran Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 470003480@QQ.COM
Country: CHINA
ProdList: 6955
Advantage: 58

Dongguan Biaobiao Experimental Equipment Technology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6672
Advantage: 58

Beijing Dongge Boye Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1861586486@qq.com
Country: CHINA
ProdList: 6648
Advantage: 58

Shanghai Qiming Biological Technology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6502
Advantage: 58

Hangzhou Lianke Biotechnology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6349
Advantage: 58

Jiangxi Jianglan Pure Biological Reagent Co., Ltd.

Tel: --
Fax: --
Email: 3245176082@qq.com
Country: CHINA
ProdList: 6134
Advantage: 58

Beijing Luyuan Bird Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 15810802415@139.com
Country: CHINA
ProdList: 6750
Advantage: 58

Shanghai Boyi Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 15800446246@163.com
Country: CHINA
ProdList: 5416
Advantage: 58

Shanghai Benrui Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: john.st@163.com
Country: CHINA
ProdList: 1471
Advantage: 58

Xiamen Huijia Biological Technology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6973
Advantage: 58

Beijing Shengke Boyuan Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 978560024@qq.com
Country: CHINA
ProdList: 6005
Advantage: 58

Shanghai Chaoyan Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 471161314@qq.com
Country: CHINA
ProdList: 6210
Advantage: 58

Shanghai Minmin Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1914109725@qq.com
Country: CHINA
ProdList: 6518
Advantage: 58

Shanghai Ziqi Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: 2453006496@qq.com
Country: CHINA
ProdList: 6184
Advantage: 58

Shanghai Weiwei Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: sales@wheybio.com
Country: CHINA
ProdList: 4398
Advantage: 58

Shanghai Wowu Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: shhebio@126.com
Country: CHINA
ProdList: 6137
Advantage: 58

Boao Pike

Tel: --
Fax: --
Email: lyn@biopike.com.cn
Country: CHINA
ProdList: 6629
Advantage: 58

Beijing Lebo Biotechnology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6057
Advantage: 58

Shanghai Yuda Industrial Co., Ltd.

Tel: --
Fax: --
Email: lucy@runwelltac.com
Country: CHINA
ProdList: 6105
Advantage: 58

Shanghai Yubo Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 344843571@qq.com
Country: CHINA
ProdList: 6318
Advantage: 58

Xiamen Research Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1562893815@qq.com
Country: CHINA
ProdList: 6936
Advantage: 58

179528-45-1, 3-(4-IODOPHENYL)-2-MERCAPTO-(Z)-2-PROPENOIC ACIDRelated Search:

Resveratrol diethyl 1-benzyl-1,4-dihydro-4-phenylpyridine-3,5-dicarboxylate ROLIPRAM GF109203X

3-(4-IODOPHENYL)-2-MERCAPTO-(Z)-2-PROPENOIC ACID

PD 150606

PD-123319-d6 Bis(Trifluoroacetic Acid Salt) Salt Hydrate

(2Z)-3-(4-iodophenyl)-2-mercapto-2-Propenoic acid

(Z)-3-(4-IODOPHENYL)-2-SULFANYLPROP-2-ENOIC ACID

(Z)-3-(4-iodophenyl)-2-mercaptoacrylic acid

PD150606;PD-150606;PD 150606

CS-2366

PD150606 (PD 150606

(Z)-3-(4-Iodophenyl)-2-mercapto-2-propenoic acid

2-Propenoic acid, 3-(4-iodophenyl)-2-mercapto-, (2Z)-

(2Z)-3-(4-iodophenyl)-2-sulfanylprop-2-enoic acid

179528-45-1

C9H7IO2S

Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds