ChemicalBook > CAS DataBase List > Alisol B

Alisol B

Product Name: Alisol B
CAS No.: 18649-93-9
Chemical Name: Alisol B
Synonyms: ALISOL B;Alisol B-RM;Alisol B Standard;Alisol B, 10 mM in DMSO;Alisma orientale Extract;(23S,24R)-24,25-Epoxy-11b,23-dihydroxy-8a,9b,14b-dammar-13(17)-en-3-one;(8α,9β,14β,23S,24R)-11β,23-Dihydroxy-24,25-epoxy-5α-dammar-13(17)-en-3-one;Dammar-13(17)-en-3-one, 24,25-epoxy-11,23-dihydroxy-, (8α,9β,11β,14β,23S,24R)-;(5R,8S,9S,10S,11S,14R)-17-((2R,4S)-4-((R)-3,3-Dimethyloxiran-2-yl)-4-hydroxybutan-2-yl)-11-hydroxy-4,4,8,10,14-pentamethyl-1,2,4,5,6,7,8,9,10,11,12,14,15,16-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one
CBNumber: CB6775041
Molecular Formula: C30H48O4
Formula Weight: 472.7
MOL File: 18649-93-9.mol

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Alisol B Property

Melting point:: 166-168 °C
Boiling point:: 575.1±50.0 °C(Predicted)
Density: 1.12±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Soluble in chloroform, DMSO and methanol;
form: powder
pka: 14.35±0.20(Predicted)
color: White
Water Solubility: insoluble in water
InChIKey: GBJKHDVRXAVITG-GMGBHDGLNA-N
SMILES: C[C@]12CC[C@@]3([H])C(C(=O)CC[C@]3(C)[C@]1([H])[C@H](CC1=C([C@H](C)C[C@@H]([C@@]3([H])OC3(C)C)O)CC[C@]21C)O)(C)C |&1:1,4,11,13,15,19,22,23,32,r|

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Safety

HS Code: 29329990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL84199
Product name: Alisol B
Purity: phyproof? Reference Substance
Packaging: 10MG
Price: $576
Updated: 2025/07/31

Usbiological

Product number: 361749
Product name: Alisol B
Packaging: 10mg
Price: $490
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PXT0003612
Product name: ALISOL B
Purity: 95.00%
Packaging: 5MG
Price: $501.57
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb105897
Product name: Alisol B
Purity: >98%,Standard References Grade
Packaging: 20mg
Price: $569.5
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA44561
Product name: Alisol B
Packaging: 25mg
Price: $385
Updated: 2021/12/16

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Alisol B Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from the rhizome of Alisma orientalis.

Uses

Alisol B is a potentially novel therapeutic compound for bone disorders by targeting the differentiation of osteoclasts as well as their functions. IC50 Value: Target: In vitro: The in vitro cultured human renal tubular epithelial HK-2 cells were intervened with 5 ng/mL transforming growth factor-beta (TGF-beta), 0.1 micromol C3a, and 0.1 micromol C3a + 10 micromol alisol B, respectively. Exogenous C3a could induce renal tubular EMT. Alisol B was capable of suppressing C3a induced EMT [1]. Alisol-B strongly inhibited RANKL-induced osteoclast formation when added during the early stage of cultures, suggesting that alisol-B acts on osteoclast precursors to inhibit RANKL/RANK signaling. Among the RANK signaling pathways, alisol-B inhibited the phosphorylation of JNK, which are upregulated in response to RANKL in bone marrow macrophages, alisol-B also inhibited RANKL-induced expression of NFATc1 and c-Fos, which are key transcription factors for osteoclastogenesis. In addition, alisol-B suppressed the pit-forming activity and disrupted the actin ring formation of mature osteoclasts [2]. Alisol B induced calcium mobilization from internal stores, leading to autophagy through the activation of the CaMKK-AMPK-mammalian target of rapamycin pathway. Moreover, the disruption of calcium homeostasis induces endoplasmic reticulum stress and unfolded protein responses in alisol B-treated cells, leading to apoptotic cell death. Finally, by computational virtual docking analysis and biochemical assays, it was showed that the molecular target of alisol B is the sarcoplasmic/endoplasmic reticulum Ca(2+) ATPase [3]. In vivo:

Definition

ChEBI: Alisol B is a triterpenoid.

target

TGF-β/Smad | JNK | AMPK | Calcium Channel | ATPase

References

[1] Zhang RF, et al.[Alisol B inhibited complement 3a-induced human renal tubular epithelial to mesenchymal transition]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2012 Oct;32(10):1407-12. PMID:23163157
[2] Lee JW, et al. Alisol-B, a novel phyto-steroid, suppresses the RANKL-induced osteoclast formation and prevents bone loss in mice. Biochem Pharmacol. 2010 Aug 1;80(3):352-61. DOI:10.1016/j.bcp.2010.04.014
[3] Law BY, et al. Alisol B, a novel inhibitor of the sarcoplasmic/endoplasmic reticulum Ca(2+) ATPase pump, induces autophagy, endoplasmic reticulum stress, and apoptosis. Mol Cancer Ther. 2010 Mar;9(3):718-30. DOI:10.1158/1535-7163.MCT-09-0700

Alisol B Preparation Products And Raw materials

Raw materials

Preparation Products

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Alisol B Suppliers

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View Lastest Price from Alisol B manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Alisol B 18649-93-9
Price: US $0.00/mg
Min. Order: 20mg
Purity: ≥95%(HPLC)
Supply Ability: 10 g
Release date: 2020-03-04

18649-93-9, Alisol BRelated Search:

Resin epoxy (8α,9β,14β,23S,24R)-11β,23-Dihydroxy-24,25-epoxy-5α-dammar-13(17)-ene-3,16-dione Pachymic acid Terrestrosin K Terrestrosin D roburic acid Carboxyatractyloside ALLEOSIDE A 25-Methoxyalisol A Alisol A 24-acetate Alisol C 23-acetate Alisol F 24-acetate Alisol F Alisol A Alisol B acetate 25-Anhydroalisol A Alisol O 1,2-EPOXYEICOSANE

ALISOL B

(23S,24R)-24,25-Epoxy-11b,23-dihydroxy-8a,9b,14b-dammar-13(17)-en-3-one

(8α,9β,14β,23S,24R)-11β,23-Dihydroxy-24,25-epoxy-5α-dammar-13(17)-en-3-one

Alisol B Standard

Dammar-13(17)-en-3-one, 24,25-epoxy-11,23-dihydroxy-, (8α,9β,11β,14β,23S,24R)-

Alisma orientale Extract

(5R,8S,9S,10S,11S,14R)-17-((2R,4S)-4-((R)-3,3-Dimethyloxiran-2-yl)-4-hydroxybutan-2-yl)-11-hydroxy-4,4,8,10,14-pentamethyl-1,2,4,5,6,7,8,9,10,11,12,14,15,16-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one

Alisol B-RM

Alisol B, 10 mM in DMSO

18649-93-9

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

Triterpenoids