METHOXYVERAPAMIL HYDROCHLORIDE

Product Name: METHOXYVERAPAMIL HYDROCHLORIDE
CAS No.: 16662-46-7
Chemical Name: METHOXYVERAPAMIL HYDROCHLORIDE
Synonyms: D600;D600, HCL;GALLOPAMIL;(S)-Gallopamil;D 600 HYDROCHLORIDE;GALLOPAMIL HYDROCHLORIDE;(+/-)-METHOXYVERAPAMIL HCL;METHOXYVERAPAMIL HYDROCHLORIDE;Gallopamil HCl (Methoxyverapamil);(+/-)-METHOXYVERAPAMIL, HYDROCHLORIDE
CBNumber: CB6780731
Molecular Formula: C28H41ClN2O5
Formula Weight: 521.09
MOL File: 16662-46-7.mol

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METHOXYVERAPAMIL HYDROCHLORIDE Property

Melting point:: 145-148°
storage temp.: Store at -20°C
solubility: DMF: 16.7 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): 0.25 mg/ml
form: A crystalline solid
color: White to off-white

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 24270
Product name: (±)-Methoxyverapamil (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $31
Updated: 2023/06/20

Cayman Chemical

Product number: 24270
Product name: (±)-Methoxyverapamil (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $53
Updated: 2023/06/20

Cayman Chemical

Product number: 24270
Product name: (±)-Methoxyverapamil (hydrochloride)
Purity: ≥98%
Packaging: 25mg
Price: $98
Updated: 2023/06/20

Cayman Chemical

Product number: 24270
Product name: (±)-Methoxyverapamil (hydrochloride)
Purity: ≥98%
Packaging: 50mg
Price: $136
Updated: 2023/06/20

ChemScene

Product number: CS-0109891
Product name: Gallopamilhydrochloride
Purity: >98.0%
Packaging: 10mg
Price: $150
Updated: 2021/12/16

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METHOXYVERAPAMIL HYDROCHLORIDE Chemical Properties,Usage,Production

Description

Gallopamil hydrochloride is a somewhat more potent methoxy analog of calcium channel blocker verapamil with a similar profile. It is useful in the treatment of angina and auricular arrhythmia.

Originator

Knoll (W. Germany)

Uses

Gallopamil hydrochloride (Methoxyverapamil hydrochloride), a methoxy derivative of Verapamil, is a phenylalkylamine calcium antagonist[1]. Gallopamil hydrochloride inhibits acid secretion in a concentration-dependent manner with an IC50 of 10.9 μM[2]. Gallopamil hydrochloride is a potent antiarrhythmic and vasodilator agent[3].

brand name

Benpredil;Corapamil;PROCORUM.

in vivo

Gallopamil hydrochloride (Methoxyverapamil hydrochloride; i.v.; 0.2 mg/kg; for 5 min) markedly reduces ventricular tachycardia (VT) and totally prevents fibrillation (VF). Gallopamil significantly reduces systolic and diastolic blood pressure measured 5 min after injection without markedly influencing heart rate^[3].

Animal Model:	Male Wistar rats weighing 290-370 g^[3]
Dosage:	0.2 mg/kg
Administration:	i.v.; 5 min
Result:	Markedly reduced VT and totally prevented VF.

References

[1] Brogden RN, et al. Gallopamil. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in ischaemic heart disease. Drugs. 1994 Jan;47(1):93-115. DOI:10.2165/00003495-199447010-00007
[2] Sewing KF, et al. Calcium channel antagonists verapamil and gallopamil are powerful inhibitors of acid secretion in isolated and enriched guinea pig parietal cells. Pharmacology. 1983;27(1):9-14. DOI:10.1159/000137824
[3] Kirchengast M, et al. Reperfusion arrhythmias in closed-chest rats: the effect of myocardial noradrenaline depletion and Ca2(+)-antagonism. Clin Exp Pharmacol Physiol. 1991 Apr;18(4):217-21. DOI:10.1111/j.1440-1681.1991.tb01434.x

METHOXYVERAPAMIL HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHOXYVERAPAMIL HYDROCHLORIDE Suppliers

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16662-46-7, METHOXYVERAPAMIL HYDROCHLORIDERelated Search:

3-Methyl-2-(3,4-dimethoxyphenyl)butyronitrile 3,5-DIMETHOXYPHENYLACETONITRILE (-)-METHOXYVERAPAMIL HYDROCHLORIDE (3-Methoxyphenyl)acetonitrile (3,4-DIHYDROXYPHENYL)ACETONITRILE 2-ETHYL-2-METHYLBUTYRONITRILE 2-ISOPROPYL-2-PHENYLACETONITRILE Devapamil Trimethylacetonitrile 3-HYDROXY-4-METHOXYPHENETHYLAMINE HYDROCHLORIDE Hordenine hydrochloride 3-tert-Butylphenol 5-TERT-BUTYLPYROGALLOL 2-PHENYLBUTYRONITRILE (3,4-Dimethoxyphenyl)acetonitrile 2-Ethyl-2-phenylbutyronitrile 3-Methylbutanenitrile (+/-)-METHOXYVERAPAMIL HYDROCHLORIDE (D6 00) (GALLOPAMIL)

(+/-)-VERAPAMIL, METHOXY-, HYDROCHLORIDE

VERAPAMIL, (+/-)-METHOXY-, HYDROCHLORIDE

(+/-)-ALPHA-(3-[(2-[3,4-DIMETHOXYPHENYL]ETHYL)METHYLAMINO]PROPYL)-3,4,5-TRIMETHOXY-ALPHA-(1-METHYLETHYL)-BENZENEACETONITRILE HYDROCHLORIDE

GALLOPAMIL

D600

D600, HCL

D 600 HYDROCHLORIDE

[3-cyano-3-(3,4,5-trimethoxyphenyl)hex-6-yl]-(5,6-dimethoxyphenethyl)methylammonium chloride

GALLOPAMIL HYDROCHLORIDE

(S)-2-(3,4,5-Trimethoxyphenyl)-5-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]-2-(1-methylethyl)pentanenitrile

(S)-Gallopamil

(αS)-α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4,5-trimethoxy-α-(1-methylethyl)benzeneacetonitrile

(αS)-α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-α-isopropyl-3,4,5-trimethoxybenzeneacetonitrile

5-((3,4-dimethoxyphenethyl)(methyl)amino)-2-isopropyl-2-(3,4,5-trimethoxyphenyl)pentanenitrile hydrochloride

(+/-)-METHOXYVERAPAMIL HCL

(+/-)-METHOXYVERAPAMIL, HYDROCHLORIDE

METHOXYVERAPAMIL HYDROCHLORIDE

Gallopamil HCl (Methoxyverapamil)

Calcium Channel,Ca channels,Methoxyverapamil,vasodilator,calcium,antiarrhythmic,inhibit,Ca2+ channels,Gallopamil hydrochloride,Gallopamil,phenylalkylamine,Inhibitor,Verapamil

(±)-Methoxyverapamil hydrochloride in methanol

Gallopamil hydrochloride, 10 mM in DMSO

16662-46-7