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METHOXYVERAPAMIL HYDROCHLORIDE

Product Name
METHOXYVERAPAMIL HYDROCHLORIDE
CAS No.
16662-46-7
Chemical Name
METHOXYVERAPAMIL HYDROCHLORIDE
Synonyms
D600;D600, HCL;GALLOPAMIL;(S)-Gallopamil;D 600 HYDROCHLORIDE;GALLOPAMIL HYDROCHLORIDE;(+/-)-METHOXYVERAPAMIL HCL;METHOXYVERAPAMIL HYDROCHLORIDE;Gallopamil HCl (Methoxyverapamil);(+/-)-METHOXYVERAPAMIL, HYDROCHLORIDE
CBNumber
CB6780731
Molecular Formula
C28H41ClN2O5
Formula Weight
521.09
MOL File
16662-46-7.mol
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METHOXYVERAPAMIL HYDROCHLORIDE Property

Melting point:
145-148°
storage temp. 
Store at -20°C
solubility 
DMF: 16.7 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): 0.25 mg/ml
form 
A crystalline solid
color 
White to off-white
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
24270
Product name
(±)-Methoxyverapamil (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$31
Updated
2023/06/20
Cayman Chemical
Product number
24270
Product name
(±)-Methoxyverapamil (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$53
Updated
2023/06/20
Cayman Chemical
Product number
24270
Product name
(±)-Methoxyverapamil (hydrochloride)
Purity
≥98%
Packaging
25mg
Price
$98
Updated
2023/06/20
Cayman Chemical
Product number
24270
Product name
(±)-Methoxyverapamil (hydrochloride)
Purity
≥98%
Packaging
50mg
Price
$136
Updated
2023/06/20
ChemScene
Product number
CS-0109891
Product name
Gallopamilhydrochloride
Purity
>98.0%
Packaging
5mg
Price
$90
Updated
2021/12/16
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METHOXYVERAPAMIL HYDROCHLORIDE Chemical Properties,Usage,Production

Description

Gallopamil hydrochloride is a somewhat more potent methoxy analog of calcium channel blocker verapamil with a similar profile. It is useful in the treatment of angina and auricular arrhythmia.

Originator

Knoll (W. Germany)

Uses

Gallopamil hydrochloride (Methoxyverapamil hydrochloride), a methoxy derivative of Verapamil, is a phenylalkylamine calcium antagonist[1]. Gallopamil hydrochloride inhibits acid secretion in a concentration-dependent manner with an IC50 of 10.9 μM[2]. Gallopamil hydrochloride is a potent antiarrhythmic and vasodilator agent[3].

brand name

Benpredil;Corapamil;PROCORUM.

in vivo

Gallopamil hydrochloride (Methoxyverapamil hydrochloride; i.v.; 0.2 mg/kg; for 5 min) markedly reduces ventricular tachycardia (VT) and totally prevents fibrillation (VF). Gallopamil significantly reduces systolic and diastolic blood pressure measured 5 min after injection without markedly influencing heart rate[3].

Animal Model:Male Wistar rats weighing 290-370 g[3]
Dosage:0.2 mg/kg
Administration:i.v.; 5 min
Result:Markedly reduced VT and totally prevented VF.

References

[1] Brogden RN, et al. Gallopamil. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in ischaemic heart disease. Drugs. 1994 Jan;47(1):93-115. DOI:10.2165/00003495-199447010-00007
[2] Sewing KF, et al. Calcium channel antagonists verapamil and gallopamil are powerful inhibitors of acid secretion in isolated and enriched guinea pig parietal cells. Pharmacology. 1983;27(1):9-14. DOI:10.1159/000137824
[3] Kirchengast M, et al. Reperfusion arrhythmias in closed-chest rats: the effect of myocardial noradrenaline depletion and Ca2(+)-antagonism. Clin Exp Pharmacol Physiol. 1991 Apr;18(4):217-21. DOI:10.1111/j.1440-1681.1991.tb01434.x

METHOXYVERAPAMIL HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHOXYVERAPAMIL HYDROCHLORIDE Suppliers

China 29 Europe 1 Germany 1 Switzerland 2 United Kingdom 2 United States 13 Global 48
SIGMA-RBI
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Switzerland
ProdList
6896
Advantage
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Alexis Corporation
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Email
alexis-ch@alexis-corp.ch
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Switzerland
ProdList
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16662-46-7, METHOXYVERAPAMIL HYDROCHLORIDERelated Search:

3-Methyl-2-(3,4-dimethoxyphenyl)butyronitrile 3,5-DIMETHOXYPHENYLACETONITRILE (-)-METHOXYVERAPAMIL HYDROCHLORIDE (3-Methoxyphenyl)acetonitrile (3,4-DIHYDROXYPHENYL)ACETONITRILE 2-ETHYL-2-METHYLBUTYRONITRILE 2-ISOPROPYL-2-PHENYLACETONITRILE Devapamil Trimethylacetonitrile 3-HYDROXY-4-METHOXYPHENETHYLAMINE HYDROCHLORIDE Hordenine hydrochloride 3-tert-Butylphenol 5-TERT-BUTYLPYROGALLOL 2-PHENYLBUTYRONITRILE (3,4-Dimethoxyphenyl)acetonitrile 2-Ethyl-2-phenylbutyronitrile 3-Methylbutanenitrile (+/-)-METHOXYVERAPAMIL HYDROCHLORIDE (D6 00) (GALLOPAMIL)

  • (+/-)-VERAPAMIL, METHOXY-, HYDROCHLORIDE
  • VERAPAMIL, (+/-)-METHOXY-, HYDROCHLORIDE
  • (+/-)-ALPHA-(3-[(2-[3,4-DIMETHOXYPHENYL]ETHYL)METHYLAMINO]PROPYL)-3,4,5-TRIMETHOXY-ALPHA-(1-METHYLETHYL)-BENZENEACETONITRILE HYDROCHLORIDE
  • GALLOPAMIL
  • D600
  • D600, HCL
  • D 600 HYDROCHLORIDE
  • [3-cyano-3-(3,4,5-trimethoxyphenyl)hex-6-yl]-(5,6-dimethoxyphenethyl)methylammonium chloride
  • GALLOPAMIL HYDROCHLORIDE
  • (S)-2-(3,4,5-Trimethoxyphenyl)-5-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]-2-(1-methylethyl)pentanenitrile
  • (S)-Gallopamil
  • (αS)-α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4,5-trimethoxy-α-(1-methylethyl)benzeneacetonitrile
  • (αS)-α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-α-isopropyl-3,4,5-trimethoxybenzeneacetonitrile
  • 5-((3,4-dimethoxyphenethyl)(methyl)amino)-2-isopropyl-2-(3,4,5-trimethoxyphenyl)pentanenitrile hydrochloride
  • (+/-)-METHOXYVERAPAMIL HCL
  • (+/-)-METHOXYVERAPAMIL, HYDROCHLORIDE
  • METHOXYVERAPAMIL HYDROCHLORIDE
  • Gallopamil HCl (Methoxyverapamil)
  • Calcium Channel,Ca channels,Methoxyverapamil,vasodilator,calcium,antiarrhythmic,inhibit,Ca2+ channels,Gallopamil hydrochloride,Gallopamil,phenylalkylamine,Inhibitor,Verapamil
  • (±)-Methoxyverapamil hydrochloride in methanol
  • Gallopamil hydrochloride, 10 mM in DMSO
  • 16662-46-7