Tralokinumab

Product Name: Tralokinumab
CAS No.: 1044515-88-9
Chemical Name: Tralokinumab
Synonyms: Tralokinumab;CAT-354|||LP 0162;Tralokinumab (anti-IL-13);Research Grade Tralokinumab;Research Grade Tralokinumab(DHE07703)
CBNumber: CB68080758
Formula Weight: 0
MOL File: Mol file

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Tralokinumab Property

storage temp.: Store at -20°C
form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Tralokinumab Chemical Properties,Usage,Production

Uses

Tralokinumab (CAT354) is a humanized IgG4 monoclonal antibody that specifically binds to and neutralizes IL-13. Tralokinumab can be used in the research of diseases such as asthma, atopic dermatitis, and pulmonary fibrosis[1][2].

in vivo

Tralokinumab (3 mg/kg; intraperitoneal injection; once every other day; from day 35 to day 63) can inhibit pulmonary fibrosis and reduce epithelial cell apoptosis in a humanized SCID mouse model of pulmonary fibrosis^[2].

Animal Model:	Female C.B-17-scid-beige (C.B-17SCID/bg) mice received single-cell preparations of IPF and normal fibroblasts via tail vein injection^[2]
Dosage:	3 mg/kg
Administration:	Intraperitoneal injection; once every other day; from day 35 to day 63
Result:	Blocked aberrant lung remodeling, promoted lung repair and restored epithelial integrity. Significantly decreased fibrotic alterations. Reduced serum CC16 (a marker of epithelial injury) and reduced BAL caspase 3 activity. Enhanced the expression of epithelial-associated genes, including E-cadherin and all of the surfactants.

IC 50

IL-13

References

[1] A Wollenberg, et al. Tralokinumab for moderate-to-severe atopic dermatitis: results from two 52-week, randomized, double-blind, multicentre, placebo-controlled phase III trials (ECZTRA 1 and ECZTRA 2). Br J Dermatol. 2021 Mar;184(3):437-449. DOI:10.1111/bjd.19574
[2] Murray LA, et al. Targeting interleukin-13 with tralokinumab attenuates lung fibrosis and epithelial damage in a humanized SCID idiopathic pulmonary fibrosis model. Am J Respir Cell Mol Biol. 2014 May;50(5):985-94. DOI:10.1165/rcmb.2013-0342OC

Tralokinumab Preparation Products And Raw materials

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Preparation Products

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Tralokinumab Suppliers

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Tralokinumab

Research Grade Tralokinumab(DHE07703)

CAT-354|||LP 0162

Research Grade Tralokinumab

Tralokinumab (anti-IL-13)

1044515-88-9