Bococizumab

Product Name: Bococizumab
CAS No.: 1407495-02-6
Chemical Name: Bococizumab
Synonyms: Bococizumab;RN316|||PF-04950615;Bococizumab 6.17mg/ml;Bococizumab (anti-PCSK9);Research Grade Bococizumab;Research Grade Bococizumab(DHJ24004)
CBNumber: CB68080899
Formula Weight: 0
MOL File: Mol file

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Bococizumab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Bococizumab Chemical Properties,Usage,Production

Uses

Bococizumab (PF-04950615) is an anti-human PCSK9 inhibitory antibody that reduces LDL cholesterol levels. Bococizumab can be used in the research of hypercholesterolemia[1][2].

in vivo

Bococizumab (0-100 mg/kg, i.v.) decreases maternal and fetal cholesterol and does not affect rat embryo-fetal development^[2].

Animal Model:	Pregnant Sprague-Dawley (SD) rats^[1]
Dosage:	0, 10, 30, and 100 mg/kg
Administration:	Intravenous injection (i.v.)
Result:	Decreased in fetal cholesterol levels. Showed well tolerance and no effects on ovarian or uterine parameters.

References

[1] Koutaro Yokote, et al. Efficacy and Safety of Bococizumab (RN316/PF-04950615), a Monoclonal Antibody Against Proprotein Convertase Subtilisin/Kexin Type 9, in Hypercholesterolemic Japanese Subjects Receiving a Stable Dose of Atorvastatin or Treatment-Naive - Results From a Randomized, Placebo-Controlled, Dose-Ranging Study. Circ J. 2017 Sep 25;81(10):1496-1505. DOI:10.1253/circj.CJ-16-1310
[2] Sarah N Campion, et al. Decreased maternal and fetal cholesterol following maternal bococizumab (anti-PCSK9 monoclonal antibody) administration does not affect rat embryo-fetal development. Regul Toxicol Pharmacol. 2015 Nov;73(2):562-70. DOI:10.1016/j.yrtph.2015.08.007

Bococizumab Preparation Products And Raw materials

Raw materials

Preparation Products

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Bococizumab Suppliers

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1407495-02-6, BococizumabRelated Search:

Diridavumab Edrecolomab Foravirumab Matuzumab Codrituzumab Vofatamab Toripalimab Utomilumab Lenvervimab TocilizuMab

Bococizumab

Research Grade Bococizumab(DHJ24004)

RN316|||PF-04950615

Research Grade Bococizumab

Bococizumab (anti-PCSK9)

Bococizumab 6.17mg/ml

1407495-02-6