1-Bromo-2,3-dimethoxybenzene
- Product Name
- 1-Bromo-2,3-dimethoxybenzene
- CAS No.
- 5424-43-1
- Chemical Name
- 1-Bromo-2,3-dimethoxybenzene
- Synonyms
- 1-Bromo-2,3-dimethox;3-Bromoveratrole, 95%;1-BROMO-2,3-DIMETHOXYBENZENE;Benzene, 1-bromo-2,3-dimethoxy-;1-[(5-bromo-2,4-dimethoxyphenyl)methyl]-4-(2,5-dimethylphenyl)piperazine
- CBNumber
- CB6836797
- Molecular Formula
- C8H9BrO2
- Formula Weight
- 217.06
- MOL File
- 5424-43-1.mol
1-Bromo-2,3-dimethoxybenzene Property
- Melting point:
- 35-36 °C
- Boiling point:
- 114 °C(Press: 5 Torr)
- Density
- 1.412±0.06 g/cm3(Predicted)
- refractive index
- 1.5565
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Yellow to brown Solid
Safety
- HS Code
- 2902900000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 409158
- Product name
- 1-Bromo-2,3-dimethoxybenzene
- Packaging
- 100mg
- Price
- $305
- Updated
- 2021/12/16
- Product number
- B689023
- Product name
- 1-Bromo-2,3-dimethoxybenzene
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FB140201
- Product name
- 1-Bromo-2,3-dimethoxybenzene
- Packaging
- 100mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- Z4856
- Product name
- 1-Bromo-2,3-dimethoxybenzene
- Packaging
- 1g
- Price
- $131
- Updated
- 2021/12/16
- Product number
- FB140201
- Product name
- 1-Bromo-2,3-dimethoxybenzene
- Packaging
- 250mg
- Price
- $160
- Updated
- 2021/12/16
1-Bromo-2,3-dimethoxybenzene Chemical Properties,Usage,Production
Chemical Properties
Colorless liquid
Synthesis
91-16-7
5424-43-1
To a stirred solution of N,N,N',N'-tetramethylethylenediamine (TMEDA, 5.43 mL, 36.19 mmol, 1.0 eq.) in anhydrous ethyl ether (Et2O, 100 mL) was slowly added n-butyllithium (n-BuLi, 22.6 mL, 36.19 mmol, 1.0 eq., 1.6 M hexane solution) at room temperature. The mixture was stirred for 10 minutes and then 1,2-dimethoxybenzene (5.0 g, 36.19 mmol) was added. The reaction mixture was continued to be stirred at room temperature for 2.5 h. The reaction mixture was then cooled to -78 °C and a solution of anhydrous hexane (10 mL) with bromine (Br2, 1.85 mL, 36.19 mmol, 1.0 equiv) was added dropwise. The reaction was kept at -78 °C for 30 min, after which it was slowly warmed to room temperature. Upon completion of the reaction, the reaction was quenched with saturated aqueous sodium sulfite (Na2SO3, 20 mL). The reaction mixture was extracted with ethyl acetate (EtOAc, 3 × 30 mL), the organic layers were combined and washed sequentially with water and brine, dried with anhydrous sodium sulfite (Na2SO4) and concentrated under reduced pressure. The residue was purified by silica gel column chromatography with the eluent of petroleum ether/ethyl acetate (9.5:0.5 to 9:1) to afford 1-bromo-2,3-dimethoxybenzene (6.68 g, 85% yield) as a colorless oil.
References
[1] Tetrahedron Asymmetry, 2013, vol. 24, # 24, p. 1548 - 1555
[2] Patent: WO2009/27679, 2009, A1. Location in patent: Page/Page column 51-52
[3] Journal of Organic Chemistry, 1982, vol. 47, # 12, p. 2393 - 2396
1-Bromo-2,3-dimethoxybenzene Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-Bromo-2,3-dimethoxybenzene manufacturers
- Product
- 1-Bromo-2,3-dimethoxybenzene 5424-43-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-11