BIBX 1382 DIHYDROCHLORIDE
- Product Name
- BIBX 1382 DIHYDROCHLORIDE
- CAS No.
- 196612-93-8
- Chemical Name
- BIBX 1382 DIHYDROCHLORIDE
- Synonyms
- Falnid;CS-928;Falnidamol;Unii-0mu316797d;Falnidamol [inn];BIBX 1382 DIHYDROCHLORIDE;FALNIDAMOL; BIBX-1382; BIBX 1382;8-(3-Chloro-4-fluoroanilino)-2-((1-methyl-4-piperidyl)amino)pyrimido(5,4-D)pyrimidine;N4-(3-chloro-4-fluoro-phenyl)-N6-(1-methyl-4-piperidyl)pyrimido[5,4-d]pyrimidine-4,6-diamine;N8-(3-Chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl)pyrimido[5,4-d]pyrimidine-2,8-diamine
- CBNumber
- CB6842590
- Molecular Formula
- C18H19ClFN7
- Formula Weight
- 387.84
- MOL File
- 196612-93-8.mol
BIBX 1382 DIHYDROCHLORIDE Property
- Melting point:
- >217°C (dec.)
- Boiling point:
- 552.0±60.0 °C(Predicted)
- Density
- 1.427
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 8?+-.0.10(Predicted)
- color
- Pale Yellow to Yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 324832
- Product name
- EGFR Inhibitor II, BIBX1382 - CAS 196612-93-8 - Calbiochem
- Packaging
- 5MG
- Price
- $318
- Updated
- 2024/03/01
- Product number
- 29630
- Product name
- BIBX1382
- Packaging
- 1mg
- Price
- $34
- Updated
- 2024/03/01
- Product number
- 29630
- Product name
- BIBX1382
- Packaging
- 25mg
- Price
- $576
- Updated
- 2024/03/01
- Product number
- 29630
- Product name
- BIBX1382
- Packaging
- 5mg
- Price
- $150
- Updated
- 2024/03/01
- Product number
- 29630
- Product name
- BIBX1382
- Packaging
- 10mg
- Price
- $280
- Updated
- 2024/03/01
BIBX 1382 DIHYDROCHLORIDE Chemical Properties,Usage,Production
Uses
Falnidamol is a novel ErbB receptor kinase inhibitor that is more potent at inhibiting signaling induced by TGF-α than that induced by neuregulin1-β1 or anti-ErbB2 agonist antibodies.
Uses
BIBX 1382 Dihydrochloride, is a potent, selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 3 nM).
Definition
ChEBI: N4-(3-chloro-4-fluorophenyl)-N6-(1-methyl-4-piperidinyl)pyrimido[5,4-d]pyrimidine-4,6-diamine is a substituted aniline.
Biological Activity
Potent, selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC 50 = 3 nM). Displays > 1000-fold lower potency against ErbB2 (IC 50 = 3.4 μ M) and a range of other related tyrosine kinases (IC 50 > 10 μ M). Oral administration inhibits growth of established human xenografts in athymic mice.
References
1. f. f. solca, a. baum, e. langkopf, g. dahmann, k. h. heider, f. himmelsbach and j. c. van meel, j pharmacol exp ther 2004, 311, 502-509.
BIBX 1382 DIHYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
BIBX 1382 DIHYDROCHLORIDE Suppliers
View Lastest Price from BIBX 1382 DIHYDROCHLORIDE manufacturers
- Product
- BIBX 1382 dihydrochloride,N8-(3-Chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl)-pyrimido[5,4-d]pyrimidine-2,8-diaminedihydrochloride 196612-93-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2019-12-30