2-ACETYL-ISONICOTINONITRILE

Product Name: 2-ACETYL-ISONICOTINONITRILE
CAS No.: 37398-49-5
Chemical Name: 2-ACETYL-ISONICOTINONITRILE
Synonyms: 2-Acetyl-4-cyanopyridine;2-ACETYL-ISONICOTINONITRILE;2-acetyl-4-Pyridinecarbonitrile;4-Pyridinecarbonitrile, 2-acetyl-;4-Pyridinecarbonitrile, 2-acetyl- (9CI)
CBNumber: CB6846745
Molecular Formula: C8H6N2O
Formula Weight: 146.15
MOL File: 37398-49-5.mol

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2-ACETYL-ISONICOTINONITRILE Property

Boiling point:: 263.5±25.0 °C(Predicted)
Density: 1.19±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: -1.17±0.10(Predicted)
Appearance: Off-white to light yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: 3968BB
Product name: 2-Acetylisonicotinonitrile
Packaging: 100mg
Price: $589
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0093861
Product name: 2-ACETYL-ISONICOTINONITRILE
Purity: 95.00%
Packaging: 2G
Price: $1674.75
Updated: 2021/12/16

AK Scientific

Product number: 3968BB
Product name: 2-Acetylisonicotinonitrile
Packaging: 2.5g
Price: $2733
Updated: 2021/12/16

AK Scientific

Product number: 3968BB
Product name: 2-Acetylisonicotinonitrile
Packaging: 5g
Price: $3978
Updated: 2021/12/16

Chemenu

Product number: CM125243
Product name: 2-acetylisonicotinonitrile
Purity: 96%
Packaging: 5g
Price: $916
Updated: 2021/12/16

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2-ACETYL-ISONICOTINONITRILE Chemical Properties,Usage,Production

Synthesis

100-48-1

541-50-4

37398-49-5

Step 1: In a reaction flask containing a mixed solution of dichloromethane (1300 mL) and water (1100 mL) with 4-cyanopyridine (52 g, 0.5 mol), ammonium persulfate ((NH4)2S2O8) (170 g, 0.75 mol), silver nitrate (6.8 g, 0.04 mol), and aqueous sulfuric acid (40 mL, prepared from 98 mL of concentrated sulfuric acid (prepared with 400 mL of water). Subsequently, a solution of 3-oxobutanoic acid (110 g, 1.25 mol) in dichloromethane (100 mL) was added slowly and dropwise while keeping the reaction mixture at reflux. After refluxing the reaction for 2 h, the reaction mixture was alkalized with sodium carbonate powder to pH 8-9. The reaction mixture was filtered and the filtrate was extracted with dichloromethane (500 mL x 3). The organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was recrystallized by ethanol to give 2-acetylisonicotinonitrile (52.0 g, 71.9% yield).

References

[1] Patent: WO2013/150416, 2013, A1. Location in patent: Page/Page column 117

2-ACETYL-ISONICOTINONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-ACETYL-ISONICOTINONITRILE Suppliers

China 37 Europe 1 India 1 Switzerland 1 United Kingdom 1 United States 6 Global 47

Jinan Trio PharmaTech Co., Ltd.

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37398-49-5, 2-ACETYL-ISONICOTINONITRILERelated Search:

4-Cyanopyridine 2-Acetyl-4-methylpyridine 2-ACETYL-6-METHYL-ISONICOTINONITRILE 2,6-Diacetyl-4-pyridinecarbonitrile 2-ACETYL-ISONICOTINONITRILE

2-ACETYL-ISONICOTINONITRILE

4-Pyridinecarbonitrile, 2-acetyl- (9CI)

2-acetyl-4-Pyridinecarbonitrile

2-Acetyl-4-cyanopyridine

4-Pyridinecarbonitrile, 2-acetyl-

37398-49-5

ACETYLGROUP

Pyridines