5-[(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)METHYL]-2-METHYL-4-PYRIMIDINAMINE DIHYDROCHLORIDE

Product Name: 5-[(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)METHYL]-2-METHYL-4-PYRIMIDINAMINE DIHYDROCHLORIDE
CAS No.: 189744-46-5
Chemical Name: 5-[(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)METHYL]-2-METHYL-4-PYRIMIDINAMINE DIHYDROCHLORIDE
Synonyms: RO 10-5824;Ro 10-5824 dihydrochloride;2-methyl-5-[(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)methyl]pyrimidin-4-amine;4-Pyrimidinamine, 5-[(3,6-dihydro-4-phenyl-1(2H)-pyridinyl)methyl]-2-methyl-;5-[(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)METHYL]-2-METHYL-4-PYRIMIDINAMINE DIHYDROCHLORIDE
CBNumber: CB6848552
Molecular Formula: C17H20N4
Formula Weight: 280.37
MOL File: 189744-46-5.mol

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5-[(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)METHYL]-2-METHYL-4-PYRIMIDINAMINE DIHYDROCHLORIDE Property

Boiling point:: 456.7±45.0 °C(Predicted)
Density: 1.186±0.06 g/cm3(Predicted)
storage temp.: Desiccate at RT
pka: 6.49±0.40(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 2329
Product name: Ro10-5824dihydrochloride
Purity: ≥99%(HPLC)
Packaging: 10
Price: $154
Updated: 2021/12/16

Tocris

Product number: 2329
Product name: Ro10-5824dihydrochloride
Purity: ≥99%(HPLC)
Packaging: 50
Price: $628
Updated: 2021/12/16

TRC

Product number: R637503
Product name: Ro10-5824
Packaging: 25mg
Price: $210
Updated: 2021/12/16

Usbiological

Product number: 256473
Product name: Ro 10-5824 dihydrochloride
Packaging: 10mg
Price: $403
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0372993
Product name: 5-[(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)METHYL]-2-METHYL-4-PYRIMIDINAMINE DIHYDROCHLORIDE
Purity: 95.00%
Packaging: 5MG
Price: $498.69
Updated: 2021/12/16

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5-[(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)METHYL]-2-METHYL-4-PYRIMIDINAMINE DIHYDROCHLORIDE Chemical Properties,Usage,Production

Uses

The dopamine receptors play important role in cognition, memory, learning, and motor control (1). These receptors have been implicated as a therapeutic target for many psychiatric and neurological disorders. Ro 10-5824 Dihydrochloride is a selective dopamine D4?receptor partial agonist (2).

Definition

ChEBI: 2-methyl-5-[(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)methyl]-4-pyrimidinamine is an aminopyrimidine.

Biological Activity

Selective dopamine D 4 receptor partial agonist (EC 50 = 205 nM) that binds with high affinity (K i = 5.2 nM). Displays 250-fold selectivity over D 3 receptors and > 1000-fold selectivity over D 2 , D 1 and D 5 receptors.

5-[(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)METHYL]-2-METHYL-4-PYRIMIDINAMINE DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-[(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)METHYL]-2-METHYL-4-PYRIMIDINAMINE DIHYDROCHLORIDE Suppliers

China 21 Germany 1 Japan 1 United Kingdom 1 United States 4 Global 28

3B Pharmachem (Wuhan) International Co.,Ltd.

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189744-46-5, 5-[(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)METHYL]-2-METHYL-4-PYRIMIDINAMINE DIHYDROCHLORIDERelated Search:

4-Amino-5-aminomethyl-2-methylpyrimidine 5-[(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)METHYL]-2-METHYL-4-PYRIMIDINAMINE DIHYDROCHLORIDE 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride

RO 10-5824

5-[(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)METHYL]-2-METHYL-4-PYRIMIDINAMINE DIHYDROCHLORIDE

Ro 10-5824 dihydrochloride

2-methyl-5-[(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)methyl]pyrimidin-4-amine

4-Pyrimidinamine, 5-[(3,6-dihydro-4-phenyl-1(2H)-pyridinyl)methyl]-2-methyl-

189744-46-5

C17H20N42HCl