ChemicalBook > CAS DataBase List > 5-[(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)METHYL]-2-METHYL-4-PYRIMIDINAMINE DIHYDROCHLORIDE

5-[(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)METHYL]-2-METHYL-4-PYRIMIDINAMINE DIHYDROCHLORIDE

Product Name
5-[(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)METHYL]-2-METHYL-4-PYRIMIDINAMINE DIHYDROCHLORIDE
CAS No.
189744-46-5
Chemical Name
5-[(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)METHYL]-2-METHYL-4-PYRIMIDINAMINE DIHYDROCHLORIDE
Synonyms
RO 10-5824;Ro 10-5824 dihydrochloride;2-methyl-5-[(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)methyl]pyrimidin-4-amine;4-Pyrimidinamine, 5-[(3,6-dihydro-4-phenyl-1(2H)-pyridinyl)methyl]-2-methyl-;5-[(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)METHYL]-2-METHYL-4-PYRIMIDINAMINE DIHYDROCHLORIDE
CBNumber
CB6848552
Molecular Formula
C17H20N4
Formula Weight
280.37
MOL File
189744-46-5.mol
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5-[(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)METHYL]-2-METHYL-4-PYRIMIDINAMINE DIHYDROCHLORIDE Property

Boiling point:
456.7±45.0 °C(Predicted)
Density 
1.186±0.06 g/cm3(Predicted)
storage temp. 
Desiccate at RT
pka
6.49±0.40(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
2329
Product name
Ro10-5824dihydrochloride
Purity
≥99%(HPLC)
Packaging
10
Price
$154
Updated
2021/12/16
Tocris
Product number
2329
Product name
Ro10-5824dihydrochloride
Purity
≥99%(HPLC)
Packaging
50
Price
$628
Updated
2021/12/16
TRC
Product number
R637503
Product name
Ro10-5824
Packaging
25mg
Price
$210
Updated
2021/12/16
Usbiological
Product number
256473
Product name
Ro 10-5824 dihydrochloride
Packaging
10mg
Price
$403
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0372993
Product name
5-[(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)METHYL]-2-METHYL-4-PYRIMIDINAMINE DIHYDROCHLORIDE
Purity
95.00%
Packaging
5MG
Price
$498.69
Updated
2021/12/16
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5-[(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)METHYL]-2-METHYL-4-PYRIMIDINAMINE DIHYDROCHLORIDE Chemical Properties,Usage,Production

Uses

The dopamine receptors play important role in cognition, memory, learning, and motor control (1). These receptors have been implicated as a therapeutic target for many psychiatric and neurological disorders. Ro 10-5824 Dihydrochloride is a selective dopamine D4?receptor partial agonist (2).

Definition

ChEBI: 2-methyl-5-[(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)methyl]-4-pyrimidinamine is an aminopyrimidine.

Biological Activity

Selective dopamine D 4 receptor partial agonist (EC 50 = 205 nM) that binds with high affinity (K i = 5.2 nM). Displays 250-fold selectivity over D 3 receptors and > 1000-fold selectivity over D 2 , D 1 and D 5 receptors.

5-[(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)METHYL]-2-METHYL-4-PYRIMIDINAMINE DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-[(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)METHYL]-2-METHYL-4-PYRIMIDINAMINE DIHYDROCHLORIDE Suppliers

3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037
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86-21-50328109
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3bsc@sina.com
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China
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EMMX Biotechnology LLC
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888-539-0666
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info@emmx.com
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United States
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Shanghai Rechem science Co., Ltd.
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TargetMol Chemicals Inc.
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InvivoChem
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Energy Chemical
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InvivoChem
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189744-46-5, 5-[(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)METHYL]-2-METHYL-4-PYRIMIDINAMINE DIHYDROCHLORIDERelated Search:


  • RO 10-5824
  • 5-[(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)METHYL]-2-METHYL-4-PYRIMIDINAMINE DIHYDROCHLORIDE
  • Ro 10-5824 dihydrochloride
  • 2-methyl-5-[(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)methyl]pyrimidin-4-amine
  • 4-Pyrimidinamine, 5-[(3,6-dihydro-4-phenyl-1(2H)-pyridinyl)methyl]-2-methyl-
  • 189744-46-5
  • C17H20N42HCl