sec-Butylamine Property

Melting point:

-104 °C

Boiling point:

63 °C(lit.)

Density 

0.724 g/mL at 25 °C(lit.)

vapor pressure 

22.13kPa at 20℃

FEMA 

4240 | SEC-BUTYLAMINE

refractive index 

n20/D 1.3928(lit.)

Flash point:

−3 °F

storage temp. 

Flammables area

solubility 

112g/l

pka

10.56(at 25℃)

form 

Liquid

color 

Clear colorless to light yellow

Specific Gravity

0.723 (20/4℃)

Odor

Ammonia-like.

explosive limit

1.8-9.0%(V)

Odor Threshold

0.17ppm

Odor Type

fishy

Water Solubility 

MISCIBLE

Sensitive 

Air Sensitive

Merck 

14,1544

JECFA Number

1584

BRN 

1361345

Stability:

Stable, but light sensitive. Incompatible with strong oxidizing agents, strong acids. Highly flammable.

LogP

0.7-0.74

CAS DataBase Reference

13952-84-6(CAS DataBase Reference)

NIST Chemistry Reference

2-Butanamine(13952-84-6)

EPA Substance Registry System

sec-Butylamine (13952-84-6)

Safety

Hazard Codes 

F,C,N

Risk Statements 

11-20/22-35-50

Safety Statements 

9-16-26-28-36/37/39-45-61-28A

RIDADR 

UN 2733 3/PG 2

OEL

STEL: 5.0 ppm; 15.0 mg/m3

WGK Germany 

2

RTECS 

EO3325000

TSCA 

Yes

HazardClass 

3

PackingGroup 

II

HS Code 

29211980

Hazardous Substances Data

13952-84-6(Hazardous Substances Data)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H314Causes severe skin burns and eye damage

H400Very toxic to aquatic life

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

sec-Butylamine Chemical Properties,Usage,Production

Description

Sec-butylamine is an amine of butane. It can be used as a fungicide. It can be used as a fumigant for control of gangrene, skin spot and silver scurf diseases of potato tubers, citrus fruit decay. However, it is highly toxic to aquatic organisms.

Chemical Properties

Butyl amines are highly flammable, colorless liquids (n-turns yellow on standing) with ammoniacal or fishlike odors. n-isomer:

Chemical Properties

Colorless to yellow liquid; fishy ammonia aroma.

Chemical Properties

colourless liquid with an amine odour

Uses

Fungicide.

Uses

(+/-)-2-Aminobutane is an important raw material and intermediate used in organic synthesis, pharmaceuticals and agrochemicals.

Production Methods

2-Butylamine is manufactured by the condensation of methyl ethyl ketone with ammonia–hydrogen in the presence of Ni catalyst. It has been used as a fungistat.

Definition

ChEBI: A primary aliphatic amine that is butane in which one hydrogen at position 2 is replaced by an amino group. A fumigant fungicide with a high potential for bioaccumulation, it is not approved for fungicidal use in the European Union.

Aroma threshold values

High strength odor; fishy type; recommend smelling in a 0.10% solution or less.

Hazard

Flammable, dangerous fire risk.

Health Hazard

Recommended Personal Protective Equipment: Chemical safety goggles; rubber gloves and apron; respiratory protective equipment; non-sparking shoes; Symptoms Following Exposure: Inhalation causes irritation of burns of the respiratory system; exposure to concentrated vapors can cause asphyxiation. Ingestion causes burns of mouth and stomach. Contact with eyes causes lachrymation, conjunctivitis, burns, corneal edema. Contact with skin causes irritation or burns, dermatitis; General Treatment for Exposure: INHALATION: remove patient from exposure; keep him quiet; contact physician. INGESTION: give large amount of water; induce vomiting; consult a physician. EYES: flush thoroughly with water for 15 min.; call physician immediately. SKIN: remove all contaminated clothing; flood affected area with large quantities of water; consult a physician; Toxicity by Inhalation (Threshold Limit Value): Data not available; Short-Term Exposure Limits: Data not available; Toxicity by Ingestion: Grade 3; oral LD₅₀ = 380 mg/kg (rat); Late Toxicity: Data not available; Vapor (Gas) Irritant Characteristics: Vapors are moderately irritating such that personnel will not usually tolerate moderate or high concentrations; Liquid or Solid Irritant Characteristics: Severe skin irritant. Causes second- and third-degree burns on short contact and is very injurious to the eyes; Odor Threshold: Data not available.

Chemical Reactivity

Reactivity with Water: No reaction; Reactivity with Common Materials: May corrode some metals in presence of water; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Flush with water; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

Safety Profile

A poison by ingestion. A powerful irritant. Moderately toxic by skin contact. Dangerous fire hazard when exposed to heat or flame. To fight fire, use alcohol foam, water spray or mist, dry chemical. Incompatible with oxidizing materials. When heated to decomposition it emits toxic fumes of NOx. A fungicide.

Potential Exposure

Alert: (n-isomer): Possible risk of forming tumors, suspected of causing genetic defects, suspected reprotoxic hazard, Primary irritant (w/o allergic reaction), (sec-isomer): Drug. n-Butylamine is used in pharmaceuticals; dyestuffs, rubber, chemicals, emulsifying agents; photography, desizing agents for textiles; pesticides, and synthetic agents. sec-Butylamine is used as a fungistate. tert-Butylamine is used as a chemical intermediate in the production of tert-Butylaminoethyl methacrylate (a lube oil additive); as an intermediate in the production of rubber and in rust preventatives and emulsion deterrents in petroleum products. It is used in the manufacture of several drugs

Shipping

UN1125 n-Butylamine, Hazard Class: 3; Labels: 3—Flammable liquid, 8—Corrosive material. UN2014 Isobutylamine, Hazard Class: 3; Labels: 3—Flammable liquid, 8—Corrosive material

Incompatibilities

May form explosive mixture with air. May accumulate static electrical charges, and may causeignition of its vapors. n-Butylamine is a weak base; reacts with strong oxidizers and acids, causing fire and explosion hazard. Incompatible with organic anhydrides; isocyanates, vinyl acetate; acrylates, substituted allyls; alkylene oxides; epichlorohydrin, ketones, aldehydes, alcohols, glycols, phenols, cresols, caprolactum solution. Attacks some metals in presence of moisture. The tert-isomer will attack some forms of plastics

Waste Disposal

Use a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner andscrubber. All federal, state, and local environmental regulations must be observed.

References

Smilanick, J. L., and J. W. Eckert. "Growth, sporulation, and virulence of isolates of Penicillium digitatum resistant to the fungicide sec-butylamine. " Phytopathology 76.8(1986).
Graham, D. C., et al. "Use of 2-aminobutane as a fumigant for control of gangrene, skin spot and silver scurf diseases of potato tubers." Potato Research 16.2(1973):109-125.
Gutter, Y. "Combined treatment with thiabendazole and 2-aminobutane for control of citrus fruit decay." Crop Protection 4.3(1985):346-350.