ChemicalBook > CAS DataBase List > 8-Aminoquinoline

8-Aminoquinoline

Product Name
8-Aminoquinoline
CAS No.
578-66-5
Chemical Name
8-Aminoquinoline
Synonyms
QUINOLIN-8-AMINE;8-QUINOLINAMINE;Quinolin-8-ylaMine;nc066;wr6920;AS-232;8-Amino;AKOS 91147;AKOS AUF01700;8-AminoquinoL
CBNumber
CB6853868
Molecular Formula
C9H8N2
Formula Weight
144.17
MOL File
578-66-5.mol
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8-Aminoquinoline Property

Melting point:
60-65 °C (lit.)
Boiling point:
174 °C/26 mmHg (lit.)
Density 
1.1148 (estimate)
refractive index 
1.7080 (estimate)
Flash point:
174°C/26mm
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
pK1: 3.99(+1) (20°C,μ=0.01)
form 
Crystalline Powder
color 
Green to beige-brown
Water Solubility 
slightly soluble
Sensitive 
Air Sensitive
BRN 
114474
CAS DataBase Reference
578-66-5(CAS DataBase Reference)
NIST Chemistry Reference
8-Quinolinamine(578-66-5)
EPA Substance Registry System
8-Quinolinamine (578-66-5)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
68-36/37/38-20/21/22-36/38
Safety Statements 
36/37/39-26-22-36
RIDADR 
UN2811
WGK Germany 
3
RTECS 
VA9627000
Hazard Note 
Harmful/Irritant/Air Sensitive
TSCA 
Yes
HazardClass 
IRRITANT
HS Code 
29334990
Toxicity
mmo-sat 50 mg/plate MUREAV 39,285,77
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
260789
Product name
8-Aminoquinoline
Purity
98%
Packaging
5g
Price
$65.9
Updated
2024/03/01
Sigma-Aldrich
Product number
260789
Product name
8-Aminoquinoline
Purity
98%
Packaging
25g
Price
$215
Updated
2024/03/01
TCI Chemical
Product number
A0419
Product name
8-Aminoquinoline
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$62
Updated
2024/03/01
TCI Chemical
Product number
A0419
Product name
8-Aminoquinoline
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$198
Updated
2024/03/01
Alfa Aesar
Product number
A16752
Product name
8-Aminoquinoline, 98+%
Packaging
1g
Price
$18.65
Updated
2024/03/01
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8-Aminoquinoline Chemical Properties,Usage,Production

Chemical Properties

green to beige-brown crystalline powder

Uses

8-Aminoquinoline is used as pesticide and pharmaceutical intermediate. It has been used in the preparation of base-stabilized terminal borylene complex of osmium. It is also used in the spectrophotometric determination of bivalent palladium.

Preparation

Synthesis of 8-aminoquinoline: Under an ice bath, sulfuric acid (2.0 mL) was added onto quinoline (5 mmol, 1.0 equiv) then 65% nitric acid (3.0 equiv) were added dropwise and stirred for 4h at rt. The mixture was poured into the ice water and neutralized with NaOH; and then extracted with dichloromethane. After dried over Na2SO4 and evaporated in vacuo, used next step without purification.
Mixture of nitroquinolines and 5% Pd/C was solved in ethanol and suspension was saturated with hydrogen gas under atmospheric pressure at 40°C until the starting material was consumed. 2 h later, the mixture was filtered and evaporated. The crude product was purified by silica gel column chromatography, eluting with EtOAc in hexanes to yield the desired 8-aminoquinoline is isolated as a brown solid in a yield of 32%.
Obtained as a brown solid (231 mg, 32%); 1H NMR (500 MHz, CDCl3) δ 8.71 – 8.60 (m, 1H), 7.93 (d, J = 8.2 Hz, 1H), 7.29 – 7.16 (m, 2H), 7.02 (d, J = 8.1 Hz, 1H), 6.80 (d, J = 7.4 Hz, 1H), 4.89 (s, 2H).

General Description

8-Aminoquinoline fluoresce moderately to weakly in low dielectric media but not in strongly hydrogen-bonding or acidic aqueous media. The reaction of 8-aminoquinoline with chromium (III), manganese (II), iron (II) and (III), cobalt (II), nickel (II), copper (II), zinc (II), cadmium (II) and platinum (II) salts has been studied.

Safety Profile

Human mutation data reported.When heated to decomposition it emits toxic fumes ofNOx.

Purification Methods

8-Aminoquinoline crystallises from EtOH, ligroin, octane or H2O, and complexes with metals. [Beilstein 22 III/IV 4708, 22/10 V 316.]

8-Aminoquinoline Preparation Products And Raw materials

Raw materials

Preparation Products

8-Quinolineboronic acid o-Phenanthroline
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8-Aminoquinoline Suppliers

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View Lastest Price from 8-Aminoquinoline manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
8-Aminoquinoline 578-66-5
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-12-04
Hebei Mojin Biotechnology Co.,Ltd
Product
8-Aminoquinoline 578-66-5
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
50000KG/month
Release date
2024-09-02
Hebei Mojin Biotechnology Co.,Ltd
Product
8-Aminoquinoline 578-66-5
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
50000KG/month
Release date
2024-08-12

578-66-5, 8-AminoquinolineRelated Search:

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