Ammonium dithiocarbamate
- Product Name
- Ammonium dithiocarbamate
- CAS No.
- 513-74-6
- Chemical Name
- Ammonium dithiocarbamate
- Synonyms
- AMMoniuM carbaModithioate;Nsc202959;Arotinolol impurity 3;Aoniu carbaodithioate;Ripretinib Impurity 27;Ammonium sulfocarbamate;ammonium dithiocarbamate;Dithiocarbamic acid ammonium;Carbamodithioic acid ammonium;Dithiocarbamic acid ammonium salt
- CBNumber
- CB6855125
- Molecular Formula
- CH6N2S2
- Formula Weight
- 110.2
- MOL File
- 513-74-6.mol
Ammonium dithiocarbamate Property
- Melting point:
- 99° (dec)
- Density
- d420 1.451
- refractive index
- 1.5300 (estimate)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Methanol (Slightly), Water (Slightly)
- form
- yellow orthorhombic crystals
- color
- Yellow
- Water Solubility
- soluble H2O [MER06]
- Stability:
- Air sensitive, Hygroscopic
- InChI
- InChI=1S/CH3NS2.H3N/c2-1(3)4;/h(H3,2,3,4);1H3
- InChIKey
- DCYNAHFAQKMWDW-UHFFFAOYSA-N
- SMILES
- C(=S)(S)N.N
- EPA Substance Registry System
- Ammonium dithiocarbamate (513-74-6)
Safety
- Hazardous Substances Data
- 513-74-6(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A633905
- Product name
- AmmoniumDithiocarbamate
- Packaging
- 1g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FA151678
- Product name
- Ammoniumdithiocarbamate
- Packaging
- 100g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- FA151678
- Product name
- Ammoniumdithiocarbamate
- Packaging
- 250g
- Price
- $125
- Updated
- 2021/12/16
- Product number
- FA151678
- Product name
- Ammoniumdithiocarbamate
- Packaging
- 500g
- Price
- $200
- Updated
- 2021/12/16
- Product number
- 4391BB
- Product name
- Ammoniumdithiocarbamate
- Packaging
- 500g
- Price
- $320
- Updated
- 2021/12/16
Ammonium dithiocarbamate Chemical Properties,Usage,Production
Chemical Properties
Yellow crystals. Soluble in water.
Uses
Ammonium Dithiocarbamate is an intermediate in synthesizing [6R-[6α,7β(Z)]]-7-[[(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[[4-(2-carboxyethyl)-2-thiazolyl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid (A630540), an isomer of the antibiotic Cefodizime (C242865) which is a third generation cephalosporin with a broad spectrum of antibacterial activity.
Uses
Instead of H2S or (NH4)2S for pptg metals in chemical analysis; synthesis of heterocyclic compounds.
Preparation
Ammonium dithiocarbamate is prepared most easily from ammonia and carbon disulfide in alcohol or an ester solvent.
Synthesis
75-15-0
513-74-6
GENERAL STEPS: Ammonia (1 equiv.) was passed into a solution of carbon disulfide (16.7 g, 0.22 mol) in tetrahydrofuran (THF, 100 mL) according to the literature methodology, and the reaction temperature was controlled to be below 45 °C. After 1 h of reaction, the mixture was cooled to room temperature to terminate the reaction. Excess ammonia was removed by passing nitrogen for 30 min or rotary evaporation. The precipitate was collected by filtration to afford ammonium dithiocarbamate (23.1 g, 96% yield) as a white solid. Methyl iodide (17.8 g, 0.125 mol) was added to a solution of ammonium dithiocarbamate (5.5 g, 0.05 mol) in acetone (100 mL) at room temperature and the reaction was stirred for 24 hours. The solid was collected by filtration, washed with cold acetone (20 mL) and dried under vacuum to give a white solid of S,S'-dimethyliminodithiocarbamate ammonium iodide (18.9 g, 96% yield). The S,S'-dimethyliminodithiocarbonate ammonium iodide (7.9 g, 0.02 mol) was treated with saturated sodium bicarbonate (NaHCO3) aqueous solution (100 mL × 2), and the organic product was extracted with dichloromethane (50 mL). The organic layer was dried with anhydrous sodium sulfate (Na2SO4) and concentrated in vacuum to give a clear colorless liquid product (2.3 g, 95% yield). The product was confirmed by 1H NMR (400 MHz, CDCl3) δ 8.88 (s, 1H), 2.42 (s, 6H); 13C NMR (101 MHz, CDCl3) δ 172.10, 14.50; HRMS (ESI+) m/z calculated value of C3H8N+ 122.0098, measured value 122.0096.
References
[1] Tetrahedron Letters, 2015, vol. 56, # 44, p. 6097 - 6099
[2] Journal of Medicinal Chemistry, 2010, vol. 53, # 1, p. 77 - 105
[3] Patent: TWI609015, 2017, B. Location in patent: Paragraph 0187; 0188
[4] Zeitschrift fur Anorganische und Allgemeine Chemie, 2010, vol. 636, # 2, p. 356 - 362
[5] Journal fuer Praktische Chemie (Leipzig), 1868, vol. <1>103, p. 178
Ammonium dithiocarbamate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ammonium dithiocarbamate manufacturers
- Product
- Ammonium dithiocarbamate 513-74-6
- Price
- US $1.00-4.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200000KG
- Release date
- 2025-05-14
- Product
- Ammonium dithiocarbamate 513-74-6
- Price
- US $0.00/G/KG
- Min. Order
- 1G/KG
- Purity
- 99%
- Supply Ability
- 100MT
- Release date
- 2025-04-22
- Product
- Ammonium dithiocarbamate 513-74-6
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98.00%
- Supply Ability
- 20tons
- Release date
- 2023-09-12