ChemicalBook > CAS DataBase List > Methyl 2-(4-methylphenylsulfonamido)acetate

Methyl 2-(4-methylphenylsulfonamido)acetate

Product Name
Methyl 2-(4-methylphenylsulfonamido)acetate
CAS No.
2645-02-5
Chemical Name
Methyl 2-(4-methylphenylsulfonamido)acetate
Synonyms
T0514-7020;Alkalamide;TsNHCH2COOCH3;methyltosylglycinate;Roxadustat Impurity 26;isopropyl 2-acetyl-4-phenoxybenzoate;N-(Toluene-4-sulfonyl)glycine methyl ester;N-(Toluene-4-sulphonyl)glycine methyl ester;methyl 2-(4-methylphenylsulfonamido)acetate;Methyl N-[(4-methylphenyl)sulfonyl]glycinate
CBNumber
CB6855372
Molecular Formula
C10H13NO4S
Formula Weight
243.28
MOL File
2645-02-5.mol
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Methyl 2-(4-methylphenylsulfonamido)acetate Property

Melting point:
89-91°C
Boiling point:
372.5±52.0 °C(Predicted)
Density 
1.261
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
9.09±0.50(Predicted)
color 
White to Off-White
InChI
InChI=1S/C10H13NO4S/c1-8-3-5-9(6-4-8)16(13,14)11-7-10(12)15-2/h3-6,11H,7H2,1-2H3
InChIKey
GYQBPYXMRNEAKZ-UHFFFAOYSA-N
SMILES
C(OC)(=O)CNS(C1=CC=C(C)C=C1)(=O)=O
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Safety

HS Code 
2935909099
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
M339660
Product name
Methyl2-(4-methylphenylsulfonamido)acetate
Packaging
5g
Price
$55
Updated
2021/12/16
Oakwood
Product number
211823
Product name
Methyl2-(4-methylphenylsulfonamido)acetate
Purity
99%
Packaging
100g
Price
$90
Updated
2021/12/16
SynQuest Laboratories
Product number
8769-1-Y8
Product name
N-(Toluene-4-sulfonyl)glycine methyl ester
Packaging
25g
Price
$125
Updated
2021/12/16
SynQuest Laboratories
Product number
8769-1-Y8
Product name
N-(Toluene-4-sulfonyl)glycine methyl ester
Packaging
100g
Price
$244
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0979518
Product name
(TOLUENE-4-SULFONYLAMINO)-ACETIC ACID METHYL ESTER
Purity
95.00%
Packaging
5MG
Price
$495.73
Updated
2021/12/16
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Methyl 2-(4-methylphenylsulfonamido)acetate Chemical Properties,Usage,Production

Synthesis

5680-79-5

98-59-9

2645-02-5

The general experimental procedure was as follows: glycine methyl ester hydrochloride (10 mmol) and sodium carbonate (2.1 g, 20 mmol) were dissolved in anhydrous dichloromethane (50 mL) and cooled in an ice bath. Subsequently, p-toluenesulfonyl chloride (1.9 g, 10 mmol) was added. The reaction mixture was stirred at room temperature overnight. After the reaction was completed, more dichloromethane was added and the organic layer was washed sequentially with 0.1 M hydrochloric acid, saturated sodium bicarbonate solution and brine. The organic phase was dried with anhydrous sodium sulfate and concentrated in vacuum to give the crude product. The crude product was purified by silica gel column chromatography using hexane and ethyl acetate (1:1) as eluent. Methyl 2-(4-methylphenylsulfonylamino)acetate (compound G2) was finally obtained in 78% yield as a white solid.1H NMR (400 MHz, CDCl3): δ 7.74 (d, J = 8.3 Hz, 2H, ArH), 7.31 (d, J = 8.3 Hz, 2H, ArH), 5.04 (t, J = 5.1 Hz, 1H, - NH-), 3.78 (d, J = 5.1 Hz, 2H, -CH2-), 3.64 (s, 3H, -OCH3), 2.42 (s, 3H, -CH3) ppm. 13C NMR (100 MHz, CDCl3): δ 169.4, 144.0, 136.3, 129.9, 127.4, 52.7, 44.2, 21.7 ppm. 21.7 ppm.Calculated elemental values [C10H13NO4S]: C, 49.37; H, 5.39; N, 5.76; S, 13.18.Measured values: C, 50.63; H, 5.09; N, 5.36; S, 12.87.

References

[1] Organic Letters, 2005, vol. 7, # 25, p. 5717 - 5719
[2] ChemMedChem, 2011, vol. 6, # 8, p. 1459 - 1470
[3] Journal of Medicinal Chemistry, 2013, vol. 56, # 18, p. 7190 - 7200
[4] Tetrahedron, 2008, vol. 64, # 52, p. 11884 - 11895
[5] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 9, p. 982 - 986

Methyl 2-(4-methylphenylsulfonamido)acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Methyl 2-(4-methylphenylsulfonamido)acetate manufacturers

Zhengzhou Anbu Chem Co.,Ltd
Product
Methyl 2-(4-methylphenylsulfonamido)acetate 2645-02-5
Price
US $0.00/KG
Min. Order
0.1KG
Purity
99%
Supply Ability
1000KGS
Release date
2023-06-13
Career Henan Chemical Co
Product
Methyl 2-(4-methylphenylsulfonamido)acetate 2645-02-5
Price
US $100.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
Customized
Release date
2018-07-26

2645-02-5, Methyl 2-(4-methylphenylsulfonamido)acetate Related Search:

Cellulose acetate Methyl benzoylformate Tosyl cyanide Methyl p-toluenesulfonate Tosyl chloride Ammonium acetate Sodium acetate Vinyl acetate Ethyl acetate p-Toluenesulfonamide Benzyl acetate Butyl acetate TOLBUTAMIDE Methyl acetate Magnesium acetate Methyl Propargyl p-toluenesulfonate 3-Butynyl p-toluenesulfonate

  • methyl 2-(4-methylphenylsulfonamido)acetate
  • Methyl 2-[(4-Methylbenzene)sulfonaMido]acetate
  • Methyl N-[(4-methylphenyl)sulphonyl]glycinate, N-Tosylglycine methyl ester, Methyl [(4-methylphenyl)sulphonamido]acetate
  • N-(Toluene-4-sulphonyl)glycine methyl ester
  • methyl 2-[(4-methylphenyl)sulfonylamino]acetate
  • methyltosylglycinate
  • T0514-7020
  • TsNHCH2COOCH3
  • Methyl N-[(4-methylphenyl)sulfonyl]glycinate
  • N-(Toluene-4-sulfonyl)glycine methyl ester
  • Glycine, N-[(4-methylphenyl)sulfonyl]-, methyl ester
  • Methyl 2-(4-methylphenylsulfonamido)acetate USP/EP/BP
  • Roxadustat Impurity 26
  • N-[(4-Methylphenyl)sulfonyl]glycine methyl ester
  • isopropyl 2-acetyl-4-phenoxybenzoate
  • Alkalamide
  • 2645-02-5