ChemicalBook > CAS DataBase List > Cefazedone sodium salt
Cefazedone sodium salt
- Product Name
- Cefazedone sodium salt
- CAS No.
- 63521-15-3
- Chemical Name
- Cefazedone sodium salt
- Synonyms
- Nsc304118;Refosporin sodium salt;Cefazedone, sodium salt;Cefazedone sodium salt USP/EP/BP;Sodium (6R,7R)-7-[[(3,5-dichloro-4-oxo-1(4H)-pyridyl)acetyl]amino]-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;sodium (6R-trans)-7-[[(3,5-dichloro-4-oxo-1(4H)-pyridyl)acetyl]amino]-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;(6R,7R)-7-[[2-(3,5-Dichloro-4-oxopyridin-1(4H)-yl)acetyl]amino]-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(3,5-dichloro-4-oxo-1(4H)-pyridinyl)acetyl]amino]-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-, monosodium salt, (6R-trans)-
- CBNumber
- CB6878809
- Molecular Formula
- C18H14Cl2N5NaO5S3
- Formula Weight
- 570.42503
- MOL File
- 63521-15-3.mol
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Safety
- Toxicity
- LD50 in mice, rats, rabbits, dogs (mg/kg): 6800, 4225, 3200, 3000 i.v. (von Eberstein)
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N-Bromosuccinimide Price
American Custom Chemicals Corporation
- Product number
- APN0000622
- Product name
- CEFAZEDONE SODIUM SALT
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1218.53
- Updated
- 2021/12/16
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Cefazedone sodium salt Chemical Properties,Usage,Production
Originator
Cefazedone Sodium,Arocor Holdings Inc.
Manufacturing Process
A solution of 1 eq. of the tert-butyl ester of 7-aminocephalosporanic acid and
1 eq. of dicyclohexylcarbodiimide in 100 ml of methylene chloride/DMF (1:1)
is cooled to 0°C. The mixture is combined with 1 eq. of 3,5-dichloro-4-
pyridone-1-acetic acid; after 5 min the ice bath is removed and the mixture
agitated for another 30 min at 25°C. The thus-formed urea is filtered off and
the filtrate filtered over silica gel (eluent: ethyl acetate/1% methanol). The
solvent is concentrated by evaporation, and the thus-obtained tert-butyl ester
of 7-(3,5-dichloro-1,4-dihydro-4-oxo-1-pyridylacetamido)cephalosporanic acid
is crystallized from ether.
1 eq. of the tert-butyl ester is dissolved in 30 ml of trifluoroacetic acid. After
30 minutes, the solution is evaporated and the thus-produced 7-(3,5-dichloro-
1,4-dihydro-4-oxo-1-pyridylacetamido)cephalosporanic acid crystallized from
ether.
1 eq. of the obtained 7-(3,5-dichloro-1,4-dihydro-4-oxo-1-pyridylacetamido)
cephalosporanic acid is dissolved in 60 ml of saturated aqueous sodium
bicarbonate solution at a pH of below 7 and combined with 1 eq. of 5-methyl-
1,3,4-thiadiazole-2-thiol in 20 ml of acetone. The reaction solution is agitated
for 2 hours at 80°C and at a pH of 6.3 under a nitrogen atmosphere. The
acetone is thereupon removed, the solution is washed with ether and acidified
to pH 2. The thus-obtained 3-(1-methyltetrazolyl-5-mercaptomethyl)-7-(3,5-
dichloro-1,4-dihydro-4-oxo-1-pyridylacetamido)-3-cephem-4-carboxylic acid is
filtered off and dried. IR spectrum confirmed the structure of cefazedone.
In practice it is usually used as sodium salt.
Therapeutic Function
Antibiotic
Cefazedone sodium salt Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Cefazedone sodium salt manufacturers
Hebei Henghe Import and Export Trading Co. LTD
- Product
- Cefazedone sodium 63521-15-3
- Price
- US $260.00/KG
- Min. Order
- 10KG
- Purity
- 99%
- Supply Ability
- 10
- Release date
- 2020-12-09
Hebei Runbin Biotechnology Co. LTD
- Product
- Cefazedone sodium salt 63521-15-3
- Price
- US $235.00/KG
- Min. Order
- 1KG
- Purity
- 99%min
- Supply Ability
- 8000 Kilogram/Kilograms per Month
- Release date
- 2020-08-25
Shaanxi Dideu Medichem Co. Ltd
- Product
- Cefazedone sodium salt 63521-15-3
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 500 MT
- Release date
- 2020-05-25
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