2-(2-aminoethoxy)pyridine

Product Name: 2-(2-aminoethoxy)pyridine
CAS No.: 29450-07-5
Chemical Name: 2-(2-aminoethoxy)pyridine
Synonyms: NSC 91884;2-(Pyridin-2-yloxy);2-(2-aminoethoxy)pyridine;2-(2-Pyridyloxy)ethanaMine;2-(2-pyridyloxy)ethylamine;2-(2-Pyridinyloxy)ethanamine;2-(pyridin-2-yloxy)ethanaMine;2-(Pyridin-2-yloxy)-ethylamine;Ethanamine, 2-(2-pyridinyloxy)-;2-(pyridin-2-yloxy)ethan-1-amine
CBNumber: CB6879088
Molecular Formula: C7H10N2O
Formula Weight: 138.17
MOL File: 29450-07-5.mol

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2-(2-aminoethoxy)pyridine Property

Melting point:: 216-222 °C
Boiling point:: 238 °C
Density: 1.089±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 8.22±0.10(Predicted)

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: B525700
Product name: 2-(Pyridin-2-yloxy)ethanamine
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Apolloscientific

Product number: OR929033
Product name: 2-(Pyridin-2-yloxy)ethanamine
Purity: 98%
Packaging: 1g
Price: $155
Updated: 2021/12/16

Apolloscientific

Product number: OR929033
Product name: 2-(Pyridin-2-yloxy)ethanamine
Purity: 98%
Packaging: 5g
Price: $495
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0388612
Product name: 2-(PYRIDIN-2-YLOXY)ETHANAMINE
Purity: 95.00%
Packaging: 5MG
Price: $495.22
Updated: 2021/12/16

AK Scientific

Product number: W5199
Product name: 2-(Pyridin-2-yloxy)ethanamine
Packaging: 5g
Price: $584
Updated: 2021/12/16

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2-(2-aminoethoxy)pyridine Chemical Properties,Usage,Production

Synthesis

109-09-1

141-43-5

29450-07-5

Sodium hydride (60% dispersed in mineral oil, 6.63 g, 166 mmol) was slowly added to a solution of 2-aminoethanol (10.0 mL, 166 mmol) in dioxane (150 mL) at room temperature and under nitrogen atmosphere. After stirring for 10 minutes, 2-chloropyridine (15.6 mL, 166 mmol) was added and the reaction mixture was subsequently heated to reflux. After maintaining reflux stirring for 14 hours, it was cooled to room temperature and the reaction mixture was diluted with water (100 mL) and dichloromethane (200 mL). The aqueous layer was separated and extracted with dichloromethane (2 x 100 mL). The organic phases were combined, washed with brine (200 mL), dried over magnesium sulfate, filtered and concentrated to give an orange colored oil. Purification by rapid column chromatography on silica gel using a 50% (80:18:2 CHCl3/MeOH/concentrated NH4OH) solution of dichloromethane as eluent gave 2-(2-pyridinyloxy)ethylamine as a yellow oil (17.9 g, 78%).1H NMR (CDCl3) δ 8.09-8.15 (m, 1H), 7.53-7.56 (m , 1H), 6.80-6.85 (m, 1H), 6.70-6.75 (m, 1H), 4.27-4.31 (m, 2H), 3.06-3.10 (m, 2H); MS (ES): m/z 139 (M + H). 2-(Pyridin-2-yloxy)ethylamine (500 mg, 3.62 mmol) was added to a solution of 2-thioacetyl-isoindole-1,3-dione (743 mg, 3.62 mmol) in CHCl3 (18 mL) at 0 °C. After stirring for 15 min, the reaction solution was concentrated, redissolved in ethyl acetate (25 mL), filtered and concentrated again. Purification by silica gel fast column chromatography (SiO2, 1:1 EtOAc/hexane) afforded N-(2-(pyridin-2-yloxy)ethyl)thioacetamide (350 mg, 49%) as a beige/pink solid.1H NMR (CDCl3) δ 8.79 (br s, 1H), 8.10-8.08 (m, 1H), 7.58-7.65 (m , 1H), 6.92-7.00 (m, 1H), 6.76-6.82 (m, 1H), 4.57-4.65 (m, 2H), 3.98-4.05 (m, 2H), 2.56 (s, 3H). A solution of N-(2-(pyridin-2-yloxy)ethyl)thioacetamide (50 mg, 0.25 mmol) and methyl methyl trifluoromethanesulfonate (0.028 mL, 0.25 mmol) was mixed in a solution of dichloromethane (1.5 mL), stirred at room temperature for 10 min and concentrated to dryness. To the residue was added a solution of pyridine (3 mL) of biphenyl-4-carboxylic acid (R)-(6-amino-2(R)-hydroxyindan-1-yl)amide (95 mg, 0.275 mmol), and after stirring for 18 hours at room temperature, the pyridine was removed in vacuo. Purification by silica gel fast column chromatography (SiO2, 1:1 EtOAc/hexane to 80:18:2 CHCl3/MeOH/concentrated NH4OH) afforded 2-(2-pyridinyloxy)ethanamine (21 mg, 17%) as a white solid.1H NMR (CDCl3) δ 7.88-7.95 (m, 2H), 7.65-7.74 (m, 2H ), 7.60-7.70 (m, 2H), 7.40-7.53 (m, 3H), 7.24-7.26 (m, 2H), 7.02-7.99 (m, 1H), 6.62-6.70 (m, 1H), 5.35-5.42 (m, 1H), 4.55-4.62 (m, 1H), 3.78-3.90 (m, 4H) 3.30-3.43 (m, 1H), 2.92-3.08 (m, 1H), 2.02 (s, 3H); MS (ES): m/z 507 (M + H).

References

[1] Tetrahedron, 1988, vol. 44, # 1, p. 91 - 100
[2] Patent: WO2004/94363, 2004, A1. Location in patent: Page 45-46
[3] Patent: US2004/53928, 2004, A1
[4] Patent: WO2015/71657, 2015, A1. Location in patent: Page/Page column 34; 41; 42
[5] Patent: US2004/192698, 2004, A1. Location in patent: Page/Page column 13

2-(2-aminoethoxy)pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(2-aminoethoxy)pyridine Suppliers

China 43 India 1 United Kingdom 1 United States 5 Global 50

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29450-07-5, 2-(2-aminoethoxy)pyridineRelated Search:

7-BROMO-1H-PYRIDO[2,3-B][1,4]OXAZIN-2(3H)-ONE quinisocaine 2-(2-aminoethoxy)pyridine DIMETHISOQUIN HYDROCHLORIDE (2 G) 7-CHLORO-2H-PYRIDO[2,3-B]-1,4-OXAZIN-3(4H)-ONE 1H-Pyrido[2,3-b][1,4]oxazin-2(3H)-one(9CI) 2,6-bis[2-(dimethylamino)ethoxy]pyridine 6-(2-Diethylaminoethoxy)-N-(o-methoxyphenyl)nicotinamide hydrochloride N-(2-([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]OXY)ETHYL)-3-(4-METHOXYANILINO)-N-METHYL-2-PHENYLACRYLAMIDE N-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-N-(2-([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]AMINO)ETHYL)-N-(2-([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]OXY)ETHYL)AMINE 4,6-DIMETHYL-2-(2-MORPHOLINOETHOXY)-3-PYRIDINYL 2-METHYLPHENYL SULFONE HYDROQUINIDINE 4-METHYL-2-QUINOLYL ETHER 4-Phenyl-2-((2,2-dimethylamino)ethoxy)quinoline hydrochloride N-(2-([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]OXY)ETHYL)-2-PHENYLACETAMIDE Rocastine 3-CHLORO-2-[2-(3,5-DIMETHYL-1H-PYRAZOL-1-YL)ETHOXY]-5-(TRIFLUOROMETHYL)PYRIDINE N-(2-([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]OXY)ETHYL)-N-METHYL-2-PHENYLACETAMIDE 2-((4,6-DIMETHYL-3-[(2-METHYLPHENYL)SULFONYL]-2-PYRIDINYL)OXY)-N,N-DIMETHYL-1-ETHANAMINE

2-(2-aminoethoxy)pyridine

2-(2-Pyridinyloxy)ethanamine

2-(2-pyridyloxy)ethylamine

2-(pyridin-2-yloxy)ethanaMine

2-(2-Pyridyloxy)ethanaMine

2-(Pyridin-2-yloxy)-ethylamine

NSC 91884

2-(Pyridin-2-yloxy)

Ethanamine, 2-(2-pyridinyloxy)-

2-(pyridin-2-yloxy)ethan-1-amine

29450-07-5