7-BROMO-1H-PYRIDO[2,3-B][1,4]OXAZIN-2(3H)-ONE

Product Name: 7-BROMO-1H-PYRIDO[2,3-B][1,4]OXAZIN-2(3H)-ONE
CAS No.: 105544-36-3
Chemical Name: 7-BROMO-1H-PYRIDO[2,3-B][1,4]OXAZIN-2(3H)-ONE
Synonyms: 7-BROMO-1H-PYRIDO[2,3-B][1,4]OXAZIN-2-ONE;7-BROMO-1H-PYRIDO[2,3-B][1,4]OXAZIN-2(3H)-ONE;:1H-Pyrido[2,3-b][1,4]oxazin-2(3H)-one,7-broMo;7-broMo-1H,2H,3H-pyrido[2,3-b][1,4]oxazin-2-one;6-bromo-1,2-dihydropyrido[2,3-b][1,4]oxazin-3-one;7-Bromo-1H-pyrrolo [2,3-B] [1,4] oxazine-2 (3H) - one
CBNumber: CB4839961
Molecular Formula: C7H5BrN2O2
Formula Weight: 229.03
MOL File: 105544-36-3.mol

More

Less

7-BROMO-1H-PYRIDO[2,3-B][1,4]OXAZIN-2(3H)-ONE Property

Melting point:: 247-251 °C(Solv: ethanol (64-17-5))
Boiling point:: 398.8±42.0 °C(Predicted)
Density: 1.772±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 10.67±0.20(Predicted)
form: solid
InChI: InChI=1S/C7H5BrN2O2/c8-4-1-5-7(9-2-4)12-3-6(11)10-5/h1-2H,3H2,(H,10,11)
InChIKey: UTPFXZJAASMEDW-UHFFFAOYSA-N
SMILES: O1CC(=O)NC2=CC(Br)=CN=C12

More

Less

Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3
HazardClass: IRRITANT

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: ADE001263
Product name: 7-Bromo-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one
Purity: Aldrich
Packaging: 1g
Price: $792
Updated: 2024/03/01

TRC

Product number: B155450
Product name: 7-Bromo-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one
Packaging: 50mg
Price: $90
Updated: 2021/12/16

AK Scientific

Product number: X8763
Product name: 7-Bromo-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one
Packaging: 100mg
Price: $115
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB154346
Product name: 7-Bromo-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one
Packaging: 250mg
Price: $125
Updated: 2021/12/16

ChemScene

Product number: CS-W019103
Product name: 7-Bromo-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one
Packaging: 250mg
Price: $57
Updated: 2021/12/16

More

Less

7-BROMO-1H-PYRIDO[2,3-B][1,4]OXAZIN-2(3H)-ONE Chemical Properties,Usage,Production

Uses

7-Bromo-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one is an important chemical reagent that can be used to prepare heteroaryl compounds. The synthetic product can effectively inhibit necrosis and thus finds application in the treatment of diseases and conditions related to the necrosis pathway, including, for example, inflammation, tumors, metabolic diseases, and neurodegenerative diseases such as cerebral ischemia and stroke.

Synthesis

7-Bromo-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one is prepared by reacting 6-bromo-1H-pyrrolo[3,2-b]pyridine with pyridine and cyclohexyl carbonochloridate in anhydrous THF solution. The specific reaction process is as follows: To a solution of 6-bromo-1H-pyrrolo[3,2-b]pyridine (97 mg, 0.5 mmol) in anhydrous THF (5 mL) was added slowly pyridine (120 mg, 1.5 mmol) followed by cyclohexyl carbonochloridate (162 mg, 1 mmol) in THF (2 mL). The mixture was stirred at room temperature for 3 h. The reaction was quenched by the addition of saturated NaCl solution (20 mL). The aqueous phase was extracted with EtOAc (3×) and the combined organic layers were combined, dried and concentrated. The residue was purified by silica gel column chromatography (petroleum ether/ethyl acetate = 5/1) to give 7-Bromo-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one as a colorless oily liquid (120 mg, 75%).1H NMR (400 MHz, DMSO-d6) d 8.58 (s, 2H), 7.84 (d, J = 2.4 Hz, 1H), 8.77 (d, J = 3.6 Hz, 1H), 5.13-5.00 (m, 1H), 2.13-1.97 (m, 2H), 1.91-1.75 (m, 2H), 1.72- 1.33 (m, 6H).

7-BROMO-1H-PYRIDO[2,3-B][1,4]OXAZIN-2(3H)-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

7-BROMO-1H-PYRIDO[2,3-B][1,4]OXAZIN-2(3H)-ONE Suppliers

China 101 Germany 1 India 1 United Kingdom 2 United States 9 Global 114

Shanghai Helai Biotech Co. Ltd.

Tel: 15721400568
Email: helaibiotech@163.com
Country: China
ProdList: 155
Advantage: 58

Medsyn Biotechnology Co., Ltd

Tel: 028-82250492; 15121117545
Fax: QQ 3627337140
Email: viola.liu@medsynbio.cn
Country: China
ProdList: 99
Advantage: 58

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11655
Advantage: 64

Shanghai Longsheng chemical Co.,Ltd.

Tel: 021-58099652-8005 13585536065
Fax: 021-58099609
Email: bin.wu@shlschem.com
Country: China
ProdList: 9810
Advantage: 59

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 19186
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42958
Advantage: 64

Pharmsynth Pharmaceutical (Chengdu) Technology Co.,LTD

Tel: 15528092102
Fax: On Line QQ 2415375924
Email: Pharmsynth@hotmail.com
Country: China
ProdList: 116
Advantage: 60

Shanghai Synthfine Chemical Co.,Ltd

Tel: 15921303235
Fax: QQ489466966
Email: sales@synthfine.com
Country: China
ProdList: 1001
Advantage: 58

NovoChemy Ltd.

Tel: 021-31261262/ 49 (0)17662837245
Fax: (0)21-33250524
Email: sales@novochemy.com
Country: Germany
ProdList: 6328
Advantage: 58

More

Less

View Lastest Price from 7-BROMO-1H-PYRIDO[2,3-B][1,4]OXAZIN-2(3H)-ONE manufacturers

Huida Pharmaceutical Technology (Shanghai) Co., Ltd.

Product: 7-BROMO-1H-PYRIDO[2,3-B][1,4]OXAZIN-2(3H)-ONE 105544-36-3
Price: US $0.00-0.00/kg
Min. Order: 0.10000000149011612kg
Purity: 98%
Supply Ability: 100kg
Release date: 2023-03-02

Career Henan Chemical Co

Product: 7-BROMO-1H-PYRIDO[2,3-B][1,4]OXAZIN-2(3H)-ONE 105544-36-3
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-08

105544-36-3, 7-BROMO-1H-PYRIDO[2,3-B][1,4]OXAZIN-2(3H)-ONERelated Search:

7-BROMO-1H-INDOLE-3-CARBOXYLIC ACID METHYL ESTER 7-Bromo-1H-indazol-3-amine 7-BroMo-6-azaindole-3-carbaldehyde 7-BROMO-1H-INDOL-3-METHYLAMINE METHYL 7-BROMO-1H-INDAZOLE-3-CARBOXYLATE 3-HYDROXY-7-BROMO 1H-INDAZOLE Methyl 7-bromo-1H-indole-2-carboxylate 7-BROMO-1H-INDAZOLE-3-CARBOXYLIC ACID 2-amino-5-bromopyridin-3-ol 7-BROMO-1H-PYRIDO[2,3-B][1,4]OXAZIN-2(3H)-ONE 5-Bromo-2-ethoxypyridine 5-Bromo-2-methoxypyridine 2-Hydroxy-5-bromopyridine 1H-Pyrido[2,3-b][1,4]oxazin-2(3H)-one(9CI) 5-BROMO-2-METHOXY-3-CYANOPYRIDINE 2-(2-aminoethoxy)pyridine 7-bromo-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one 6-BROMO-2H-PYRIDO[3,2-B][1,4]OXAZIN-3(4H)-ONE

7-BROMO-1H-PYRIDO[2,3-B][1,4]OXAZIN-2(3H)-ONE

7-BROMO-1H-PYRIDO[2,3-B][1,4]OXAZIN-2-ONE

7-broMo-1H,2H,3H-pyrido[2,3-b][1,4]oxazin-2-one

:1H-Pyrido[2,3-b][1,4]oxazin-2(3H)-one,7-broMo

6-bromo-1,2-dihydropyrido[2,3-b][1,4]oxazin-3-one

7-Bromo-1H-pyrrolo [2,3-B] [1,4] oxazine-2 (3H) - one

105544-36-3

C7H5BrN2O2

105544363