oxyphenisatine di(acetate)
- Product Name
- oxyphenisatine di(acetate)
- CAS No.
- 115-33-3
- Chemical Name
- oxyphenisatine di(acetate)
- Synonyms
- OXYPHENISATIN ACETATE;Isacen;Oxyphenisatin diacetate;(2-oxoindoline-3，3-diyl)bis(4，1-phenylene) dipropionate;sbfd;Levema;Isocrin;Fenisan;Isaphen;Laxocol
- CBNumber
- CB6900715
- Molecular Formula
- C24H19NO5
- Formula Weight
- 401.41
- MOL File
- 115-33-3.mol
oxyphenisatine di(acetate) Property
- Melting point:
- 244℃
- Boiling point:
- 566.5±50.0 °C(Predicted)
- Density
- 1.282±0.06 g/cm3(Predicted)
- storage temp.
- -20°C Freezer
- solubility
- Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 13.55±0.40(Predicted)
- color
- White to Off-White
Safety
- Toxicity
- LD50 oral in rat: 1900mg/kg
N-Bromosuccinimide Price
- Product number
- O868555
- Product name
- OxyphenisatinDiacetate(>90%)
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- O868555
- Product name
- OxyphenisatinDiacetate(>90%)
- Packaging
- 2.5g
- Price
- $205
- Updated
- 2021/12/16
- Product number
- CHM0297035
- Product name
- OXYPHENISATIN ACETATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.07
- Updated
- 2021/12/16
- Product number
- G727
- Product name
- Oxyphenisatinacetate
- Packaging
- 10mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- CM132933
- Product name
- (2-oxoindoline-3,3-diyl)bis(4,1-phenylene)diacetate
- Purity
- 95%+
- Packaging
- 5g
- Price
- $501
- Updated
- 2021/12/16
oxyphenisatine di(acetate) Chemical Properties,Usage,Production
Originator
Lavema,Winthrop,US,1959
Uses
Oxyphenisatin Diacetate is the pro-drug of Oxyphenisatin (O876965). Results confirm that Oxyphenisatin Diacetate inhibits the growth of breast cancer cell lines MCF7, T47D, HS578T, and MDA-MB-468.
Uses
Laxative.
Definition
ChEBI: Oxyphenisatine acetate is a member of phenols and a benzoate ester.
Manufacturing Process
235 gravimetrical parts of acetic acid anhydride (90%) are poured over 106 gravimetrical parts of diphenolisatin (Berichte der Deutschen Chemischen Gesselschsft, 18, 1885, p. 2641) and the mixture is heated on the water-bath while stirring. The solid starting material temporarily dissolves almost entirely and shortly afterwards the reaction product turns into a crystalline paste. In order to complete the reaction the heating on the water-bath is continued for a short time and then the whole is left to get cold. The reaction product may, for instance, be separated in the following manner: To the cold reaction mixture is gradually added about the same volumetrical quantity of alcohol; in this manner the excess of acetic acid anhydride is destroyed and the paste becomes thinner. Then the fluid is drawn off and the product washed with alcohol. For complete cleansing another extraction is made with warm alcohol and the product crystallized, for instance, from 10 parts of acetic acid. The product represents a light, fine crystalline powder, which is difficultly soluble or even insoluble in the usual organic solvents. Its melting point lies at 242°C.
brand name
Isocrin (Parke-Davis); Lavema (Sterling Winthrop);Acelax;Acetalax;Alophen pills;Ameiax;Api-slender;Artzone;Belloform;Biivectan;Bisflatan;Boxogetten;Brocatine;Buta pirone;Buteril;Butofen;Butolfen;Bydolax;Chlofel;Chur-lax;Ciracen;Cirotex;Cirotyl;Contax;Critex;Curolax;Darmoletten;Deililax;Dialose plus;Diasatin;Ditinil;Ditmedol;Eulaxin;Evac-u-lax;Ex-lax pills;Febutolo;Fibutrox;Fim-a-mint;Fin-a-mint gum;Fisiolax;Flib 518;Inlax;Ipebutona;Isaaxan;Isaphenyn;Izaman;Laveman;Laxan-vomoxin;Laxaseptol;Laxem;Laxnormal;Laxocoleva;Laxon;Laxos;Laxyl;Med-laxan;Menabil complex;Muxol;Naleran;Neocervulax;Neo-favmadol;Neo-soldana;Nourilax;Nurilaksi;Obstilax;Otone;Oxybutazone;Phlogase;Phlogistol;Phlogont;Potsilo;Promassoletten;Prusol;Rheumapax;Rivolax;Schokilax;Syndian;Tanderil-alka;Tete-lax;Validil.
Therapeutic Function
Laxative
World Health Organization (WHO)
Oxyphenisatine acetate was widely used as a laxative after its cathartic activity was first described in 1925. In 1969 its use was first associated with cases of acute and chronic liver disease. This association is considered by some, but not all, national drug regulatory authorities to warrant the withdrawal from the market of preparations containing oxyphenisatine and its derivatives.
oxyphenisatine di(acetate) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from oxyphenisatine di(acetate) manufacturers
- Product
- oxyphenisatine di(acetate) 115-33-3
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 0.999
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-03