cephaeline
- Product Name
- cephaeline
- CAS No.
- 483-17-0
- Chemical Name
- cephaeline
- Synonyms
- Cefalin;Cepheline;Aids002677;cephaeline;Alangine B;Aids-002677;Cephaelinel;(-)-Cephaelin;Desmethylemetine;Dihydropsychotrine
- CBNumber
- CB6904960
- Molecular Formula
- C28H38N2O4
- Formula Weight
- 466.61
- MOL File
- 483-17-0.mol
cephaeline Property
- Melting point:
- 115-1160C
- alpha
- D20 -43.4° (c = 2 in chloroform)
- Boiling point:
- 569.42°C (rough estimate)
- Density
- 1.21±0.1 g/cm3 (20 ºC 760 Torr)
- refractive index
- 1.5800 (estimate)
- storage temp.
- -20°C Freezer
- solubility
- Acetonitrile: slightly soluble; Chloroform: slightly soluble; Ethanol: slightly soluble; Methanol: slightly soluble
- form
- A crystalline solid
- pka
- 9.90±0.40(Predicted)
- color
- Light yellow to yellow
- Stability:
- Hygroscopic
Safety
- RIDADR
- 1544
- HazardClass
- 6.1(b)
- PackingGroup
- III
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H300Fatal if swallowed
H330Fatal if inhaled
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P284Wear respiratory protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P310Immediately call a POISON CENTER or doctor/physician.
P320Specific treatment is urgent (see … on this label).
P321Specific treatment (see … on this label).
P330Rinse mouth.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 20916
- Product name
- Cephaeline
- Purity
- ≥95%
- Packaging
- 500μg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 20916
- Product name
- Cephaeline
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $176
- Updated
- 2024/03/01
- Product number
- C256700
- Product name
- Cephaeline
- Packaging
- 2.5mg
- Price
- $270
- Updated
- 2021/12/16
- Product number
- PXT0005261
- Product name
- CEPHAELINE
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $1732.5
- Updated
- 2021/12/16
- Product number
- FC19891
- Product name
- Cephaeline
- Packaging
- 25mg
- Price
- $3125
- Updated
- 2021/12/16
cephaeline Chemical Properties,Usage,Production
Chemical Properties
Crystalline Solid
Uses
Cephaeline occurs in the ground roots ofipecac along with emetine. The Brazilian variety usually contains about 0.5%cephaeline. It is used as an emetic and anti amebic reagent.
Uses
Has been used as an emetic and expectorant
Definition
ChEBI: A pyridoisoquinoline comprising emetam having a hydroxy group at the 6'-position and methoxy substituents at the 7'-, 10- and 11-positions.
Health Hazard
The toxicity of cephaeline is lower than thatof emetine. The toxic effects are cumula tive. Ingestion of high doses may producehypotension, muscle weakness, and gastroin testinal problems, including nausea, vomiting, and diarrhea.
in vivo
Cephaeline (2 mg/kg, i.p.,daily for 3 days) suppresses ZIKV load and decreases the NS1 protein and ZIKV RNA in serum of ZIKV infected Ifnar1?/? mice[2].
Cephaeline (5 mg/kg, i.p.,daily for 7 days) effectively suppressed EBOV infection in EBOV mouse models[3].
Cephaeline (5, 10 mg/kg, i.p., a single dose for 12 days) plays an anti-lung cancer role by inducing ferroptosis in tumor xenograft mouse model[4].
| Animal Model: | Ifnar1?/? mice infected with ZIKV (8-9 week old, male and female)[2] |
| Dosage: | 2 mg/kg |
| Administration: | i.p.,daily for 3 days |
| Result: | Significantly lowered the serum viral load of ZIKV infected Ifnar1?/? mice and decreased the NS1 protein and ZIKV RNA in serum and liver of mice, respectively. |
| Animal Model: | EBOV mouse model[3] |
| Dosage: | 5 mg/kg |
| Administration: | i.p., daily for 7 days |
| Result: | Achieved 67% survival in EBOV infection to death in EBOV mouse model. |
| Animal Model: | Tumor xenograft mouse model injected with the lung cancer H460 cell line[4] |
| Dosage: | 5, 10 mg/kg |
| Administration: | i.p., a single dose for 12 days |
| Result: | Showed significant antitumour effects in tumor xenograft mouse model. |
IC 50
EBOV
cephaeline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from cephaeline manufacturers
- Product
- cephaeline 483-17-0
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 20 tons
- Release date
- 2019-12-27