endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate

ChemicalBook > CAS DataBase List > endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate

endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate

Product Name: endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate
CAS No.: 22235-81-0
Chemical Name: endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate
Synonyms: YB-M2;Ipratropium Impurity E;N-Isopropylnoratropine;N-DesMethyl IpratropiuM;Ipratropium Bromide Impurity 13;Ipratropium Bromide EP Impurity E;NIsopropylnoratropine,N Isopropylnoratropine;Ipratropium Bromide Impurity 13(Ipratropium EP Impurity E);Ipratropium Bromide EP Impurity E (N-Isopropyl Noratropine);N-Isopropyl Noratropine (Ipratropium Bromide EP Impurity E)
CBNumber: CB6932642
Molecular Formula: C19H27NO3
Formula Weight: 317.42258
MOL File: 22235-81-0.mol

Less

endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate Property

Melting point:: 112-114°C
Boiling point:: 448.8±45.0 °C(Predicted)
Density: 1.15±0.1 g/cm3(Predicted)
storage temp.: Refrigerator
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 14.12±0.10(Predicted)
color: White to Pale Orange

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 18611
Product name: N-Isopropylnoratropine
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 18611
Product name: N-Isopropylnoratropine
Purity: ≥98%
Packaging: 5mg
Price: $193
Updated: 2024/03/01

Cayman Chemical

Product number: 18611
Product name: N-Isopropylnoratropine
Purity: ≥98%
Packaging: 10mg
Price: $257
Updated: 2024/03/01

TRC

Product number: I872680
Product name: N-IsopropylNoratropine
Packaging: 50mg
Price: $580
Updated: 2021/12/16

ApexBio Technology

Product number: C4093
Product name: N-Isopropylnoratropine
Packaging: 10mg
Price: $291
Updated: 2021/12/16

Less

endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate Chemical Properties,Usage,Production

Chemical Properties

Off-White to Pale Orange Solid

Uses

N-Isopropyl Noratropine is a Noratropine derivative, an intermediate in the production of Ipratropium.

Biological Activity

n-isopropylnoratropine is a noratropine derivative and an intermediate in the production of ipratropium, an atropine-like bronchodilator drug via an anticholinergic pathway. n-isopropylnoratropine is used to examine the stability of ipratropium [1].muscarinic acetylcholine receptors are acetylcholine receptors that form g protein-receptor complexes in the cell membranes of certain neurons and other cells.n-isopropylnoratropine is an intermediate in the production of ipratropium and used to examine the stability of ipratropium. ipratropium exhibits broncholytic action by reducing the influence of cholinergic on the bronchial musculature. ipratropium blocks muscarinic acetylcholine receptors and therefore promotes the degradation of cgmp. ipratropium bromide (ib) is an anticholinergic bronchodilatory agent to treat chronic obstructive pulmonary disease. in anesthetized dogs, ipratropium with 0.01 and 0.1 mg/ml constricted the airways to 22 +/- 2% and 20 +/- 3% of control, respectively, whereas larger concentrations caused bronchodilation [2]. in moderate asthmatic patients, ipratropium bromide (ib) induced a significant shift of dose-response curve to inhalation of substance p (sp), suggesting that bronchoconstriction induced by sp could be attributed to a weak cholinergic activation [3].

References

[1]. kasawar gb, farooqui m. development and validation of a stability indicating rp-hplc method for the simultaneous determination of related substances of albuterol sulfate and ipratropium bromide in nasal solution. j pharm biomed anal. 2010 may 1;52(1):19-29.
[2]. groeben h, brown rh. ipratropium decreases airway size in dogs by preferential m2 muscarinic receptor blockade in vivo. anesthesiology. 1996 oct;85(4):867-73.
[3]. crimi n, palermo f, oliveri r, et al. influence of antihistamine (astemizole) and anticholinergic drugs (ipratropium bromide) on bronchoconstriction induced by substance p. ann allergy. 1990 aug;65(2):115-20.

endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate Preparation Products And Raw materials

Raw materials

Preparation Products

Less

endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate Suppliers

Canada 1 China 48 India 3 United States 8 Global 60

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94657
Advantage: 76

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Shanghai TaoSu Biochemical Technology Co., Ltd.

Tel: 021-33632979
Fax: 021-34692979
Email: info@tsbiochem.com
Country: China
ProdList: 8065
Advantage: 58

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18070
Advantage: 56

Nanjing XiZe Biotechnology CO., Ltd.

Tel: 025-66023220 0086-15250997978
Fax: 025-58362220
Email: 1511893459@qq.com
Country: China
ProdList: 7892
Advantage: 55

Shenzhen SUNGENING Bio-Medical Co., Ltd.

Tel: 0755-28967200 13631290199
Fax: 0755-28967200
Email: wxf@sungening.com
Country: China
ProdList: 9578
Advantage: 60

Sichuan jiayinglai technology CO.,LTD

Tel: 028-88457210 18123311397
Fax: QQ3213375147
Email: anna@enlaibio.com
Country: China
ProdList: 2294
Advantage: 55

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57423
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30237
Advantage: 58

Guangzhou Dreampharm Biotechnology Co., Ltd.

Tel: 020-36607679 17825480238
Fax: QQ 3008233717
Email: 3008233746@qq.com
Country: China
ProdList: 9919
Advantage: 12

SIMAGCHEM CORP

Tel: +86-13806087780
Email: sale@simagchem.com
Country: China
ProdList: 17365
Advantage: 58

Jinan blalong chemical co. LTD

Tel: 2710913286@.com
Email: 1513643261@qq.com
Country: China
ProdList: 14246
Advantage: 58

Shanghai Yanze Chemical Co., Ltd.

Tel: 021-13773155751 19975051755
Email: 260924549@qq.com
Country: China
ProdList: 8913
Advantage: 58

Shenzhen ruikai de biotechnology co., ltd.

Tel: 0755-61348847 17820674378
Fax: 0755-21016893
Email: 2682116078@qq.com
Country: China
ProdList: 7843
Advantage: 58

Nanjing wangzhixing Pharmaceutical Technology Co., Ltd

Tel: 15850510341
Fax: 025-85722793
Email: shiqingran@wzxchem.com
Country: China
ProdList: 3788
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: 029-81024372 15029046529
Fax: 029-88380327
Email: 1027@dideu.com
Country: China
ProdList: 10009
Advantage: 58

SHENZHEN PHYSTANDARD BIO-TECH CO.,LTD

Tel: 0755-0755-0755-83725350 13380397412
Fax: 0755-28094224
Email: 3001280422@qq.com
Country: China
ProdList: 10005
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44806
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Shanghai Sunway Pharmaceutical Technology Co.,Ltd.

Tel: 021-51816796-820 13611835272
Fax: 021-5161 3951
Email: sales2@sunwaypharm.com
Country: China
ProdList: 44458
Advantage: 58

Jiangsu Wansipu Technology Co., Ltd.

Tel: 17826022701
Email: 1485609990@qq.com
Country: China
ProdList: 952
Advantage: 58

Foshan Treasure Biotechnology Co., Ltd

Tel: 0757-85921206 18520245316
Email: 2329783215@qq.com
Country: China
ProdList: 12661
Advantage: 58

Changzhou Xianglong Pharmaceutical Technology Co., LTD

Tel: 0519-88910898 18661161657
Email: yaoxiangqiu2021@163.com
Country: China
ProdList: 9996
Advantage: 58

QUALITY CONTROL SOLUTIONS LTD.

Tel: 0755-66853366; 13670046396
Email: ORDERS@QCSRM.COM
Country: China
ProdList: 24342
Advantage: 58

Molcoo Chemicals Inc.

Tel: 18576690171 17386083646
Email: 3001006472@qq.com
Country: China
ProdList: 11837
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24644
Advantage: 58

Cato Research Chemicals Inc.

Tel: 020-81960175-877 18933936954
Email: tianwen.zhan@cato-chem.com
Country: China
ProdList: 7735
Advantage: 58

Shanghai YuZn Pharm. Technology Co.,Ltd.

Tel: 15921286451; 15921286451
Email: 2010681527@qq.com
Country: China
ProdList: 5115
Advantage: 58

LGC Science (Shanghai) Ltd.

Tel: 17717235263
Email: cindy.yang@lgcgroup.com
Country: China
ProdList: 15583
Advantage: 58

Sichuan HongRi Pharma-Tech Co., Ltd

Tel: 18054780191
Fax: 0838-2822568
Email: 551604319@qq.com
Country: China
ProdList: 2037
Advantage: 58

Nanjing Huanuo Biomedical Technology Co., Ltd

Tel: 18913906212
Email: 2885426135@qq.com
Country: China
ProdList: 7160
Advantage: 58

Shanghai Haohong Scientific Co., Ltd.

Tel: 400-400-8210725
Email: malulu@leyan.com
Country: China
ProdList: 39988
Advantage: 58

Tan-Mo Technology Co., Ltd.

Tel: 19850211281
Email: qiann@gbw-china.com
Country: China
ProdList: 1980
Advantage: 58

Shanghai Zerui Biotechnology Co., Ltd.

Tel: 021-54580889 18321124657
Fax: 021-54580889
Email: 731997554@qq.com
Country: China
ProdList: 10608
Advantage: 58

Hubei De'ao Chemical Research Pharmaceutical Technology Co., Ltd

Tel: 18502726233; 18502726233
Email: 3641133981@qq.com
Country: China
ProdList: 9713
Advantage: 58

Henan Vcommend Consultrading Co., Ltd.

Tel: 13393721940; 13393721940
Email: sales@vcommend.com
Country: China
ProdList: 10005
Advantage: 58

Guangzhou Zhenlin Pharmaceutical Technology Co., Ltd

Tel: 18102736234 18102736234
Email: 2208093734@qq.com
Country: China
ProdList: 7664
Advantage: 58

ShenZhen H&D Pharmaceutical Technology Co., LTD

Tel: 18126517264
Email: 2850476883@qq.com
Country: China
ProdList: 7858
Advantage: 58

Nantong Hanfang Biotechnology Co. , Ltd.

Tel: 18616537568
Email: hanfangpharma@126.com
Country: China
ProdList: 29981
Advantage: 58

Hubei Moco Chemical Co., Ltd.

Tel: 18627753421 18627756402
Fax: QQ：3001051413
Email: 3001009495@qq.com
Country: China
ProdList: 19063
Advantage: 58

Nanjing kangquan Bio-pharmaceutical Technology Co. , Ltd.

Tel: 19052800922
Email: m19052800922@163.com
Country: China
ProdList: 106
Advantage: 58

Cato Research Chemicals Inc.

Tel: 13342851930
Email: 3008394369@qq.com
Country: China
ProdList: 15726
Advantage: 58

Hubei Ruinuo Pharmaceutical Technology Co., Ltd

Tel: 13165688766
Fax: 0714-5316360
Email: 3008058375@qq.com
Country: China
ProdList: 3001
Advantage: 58

XIAMEN AMITY INDUSTRY AND TRADE CO., LTD.

Tel: +8618950047208
Email: ellena@amitychem.com
Country: China
ProdList: 39566
Advantage: 58

Guangzhou CATO Research Chemicals Inc.

Tel: +86-020-81960175-617 +8615602392859
Email: Intermediate@cato-chem.com
Country: China
ProdList: 8322
Advantage: 58

Moxin Chemicals

Tel: +8617320513646
Email: mike@molcoo.com
Country: China
ProdList: 9501
Advantage: 58

China National Standard Pharmaceutical Corporation Limited

Tel: +8615391658522
Email: overseasales@yongstandards.com
Country: China
ProdList: 11922
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

Less

View Lastest Price from endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate 22235-81-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%+
Supply Ability: 1T+
Release date: 2024-03-08

22235-81-0, endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetateRelated Search:

(endo,anti)-(±)-3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-isopropyl-8-methyl-8-azoniabicyclo[3.2.1]octane bromide DL-TROPIC ACID Tropic acid Ipratropium bromide 2-Oxo-(2H)-furo(2,3-h)-1-benzopyran A-(HYDROXYMETHYL)BENZENACETIC ACID METHYL ESTER Benzenepropanoic acid, b-oxo-a-phenyl-, methyl ester IpratropiuM BroMide IMpurity F (Mixture of DiastereoMers) endo-8-isopropyl-8-azabicyclo[3.2.1]octan-3-ol Atropine Impurity 4 Tropinone Atropine littorine (S)-Tropic acid Pseudotropine (1R,2R,4S,5S,7s,9S)-7-(((S)-3-hydroxy-2-phenylpropanoyl)oxy)-9-methyl-9-propyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-ium Atropine-d5 Atropine sulfate

endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate

N-Isopropylnoratropine

rac-(R*)-α-(Hydroxymethyl)benzeneacetic acid (1R,5S)-8-isopropyl-8-azabicyclo[3.2.1]octane-3α-yl ester

N-DesMethyl IpratropiuM

α-(HydroxyMethyl)benzeneacetic Acid (3-Endo)-8-(1-Methylethyl)-8-azabicyclo[3.2.1]- oct-3-yl Ester

α-(HydroxyMethyl)benzeneacetic Acid endo-8-(1-Methylethyl)-8- azabicyclo[3.2.1]oct-3-yl Ester

Ipratropium Bromide Impurity 13(Ipratropium EP Impurity E)

Ipratropium Impurity E

Ipratropium Bromide EP Impurity E

Benzeneacetic acid, α-(hydroxymethyl)-, (3-endo)-8-(1-methylethyl)-8-azabicyclo[3.2.1]oct-3-yl ester

Ipratropium Bromide Impurity 13（Ipratropium Bromide EP Impurity E）

endo-(1)-8-Aza-8-isopropylbicyclo(3.2.1)oct-3-yl (hydroxymethyl)phenylacetate

Ipratropium Bromide EP Impurity E (N-Isopropyl Noratropine)

N-Isopropyl Noratropine (Ipratropium Bromide EP Impurity E)

endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate

YB-M2

NIsopropylnoratropine,N Isopropylnoratropine

(1R,3r,5S)-8-Isopropyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropanoate (Ipratropium Impurity)

Ipratropium Bromide Impurity 13

(1R,3r,5S)-8-isopropyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropanoate

22235-81-0

2235-81-0

Aroamtics, Pharmaceuticals, Intermediates & Fine Chemicals

Aroamtics

Intermediates & Fine Chemicals

Pharmaceuticals