endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate

ChemicalBook > CAS DataBase List > endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate

endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate

Product Name: endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate
CAS No.: 22235-81-0
Chemical Name: endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate
Synonyms: YB-M2;Ipratropium Impurity E;N-Isopropylnoratropine;N-DesMethyl IpratropiuM;Ipratropium Bromide Impurity 13;Ipratropium Bromide EP Impurity E;NIsopropylnoratropine,N Isopropylnoratropine;Ipratropium Bromide Impurity 13(Ipratropium EP Impurity E);Ipratropium Bromide EP Impurity E (N-Isopropyl Noratropine);N-Isopropyl Noratropine (Ipratropium Bromide EP Impurity E)
CBNumber: CB6932642
Molecular Formula: C19H27NO3
Formula Weight: 317.42258
MOL File: 22235-81-0.mol

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endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate Property

Melting point:: 112-114°C
Boiling point:: 448.8±45.0 °C(Predicted)
Density: 1.15±0.1 g/cm3(Predicted)
storage temp.: Refrigerator
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 14.12±0.10(Predicted)
color: White to Pale Orange

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18611
Product name: N-Isopropylnoratropine
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 18611
Product name: N-Isopropylnoratropine
Purity: ≥98%
Packaging: 5mg
Price: $193
Updated: 2024/03/01

Cayman Chemical

Product number: 18611
Product name: N-Isopropylnoratropine
Purity: ≥98%
Packaging: 10mg
Price: $257
Updated: 2024/03/01

TRC

Product number: I872680
Product name: N-IsopropylNoratropine
Packaging: 50mg
Price: $580
Updated: 2021/12/16

ApexBio Technology

Product number: C4093
Product name: N-Isopropylnoratropine
Packaging: 10mg
Price: $291
Updated: 2021/12/16

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endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate Chemical Properties,Usage,Production

Chemical Properties

Off-White to Pale Orange Solid

Uses

N-Isopropyl Noratropine is a Noratropine derivative, an intermediate in the production of Ipratropium.

Biological Activity

n-isopropylnoratropine is a noratropine derivative and an intermediate in the production of ipratropium, an atropine-like bronchodilator drug via an anticholinergic pathway. n-isopropylnoratropine is used to examine the stability of ipratropium [1].muscarinic acetylcholine receptors are acetylcholine receptors that form g protein-receptor complexes in the cell membranes of certain neurons and other cells.n-isopropylnoratropine is an intermediate in the production of ipratropium and used to examine the stability of ipratropium. ipratropium exhibits broncholytic action by reducing the influence of cholinergic on the bronchial musculature. ipratropium blocks muscarinic acetylcholine receptors and therefore promotes the degradation of cgmp. ipratropium bromide (ib) is an anticholinergic bronchodilatory agent to treat chronic obstructive pulmonary disease. in anesthetized dogs, ipratropium with 0.01 and 0.1 mg/ml constricted the airways to 22 +/- 2% and 20 +/- 3% of control, respectively, whereas larger concentrations caused bronchodilation [2]. in moderate asthmatic patients, ipratropium bromide (ib) induced a significant shift of dose-response curve to inhalation of substance p (sp), suggesting that bronchoconstriction induced by sp could be attributed to a weak cholinergic activation [3].

References

[1]. kasawar gb, farooqui m. development and validation of a stability indicating rp-hplc method for the simultaneous determination of related substances of albuterol sulfate and ipratropium bromide in nasal solution. j pharm biomed anal. 2010 may 1;52(1):19-29.
[2]. groeben h, brown rh. ipratropium decreases airway size in dogs by preferential m2 muscarinic receptor blockade in vivo. anesthesiology. 1996 oct;85(4):867-73.
[3]. crimi n, palermo f, oliveri r, et al. influence of antihistamine (astemizole) and anticholinergic drugs (ipratropium bromide) on bronchoconstriction induced by substance p. ann allergy. 1990 aug;65(2):115-20.

endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate 22235-81-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%+
Supply Ability: 1T+
Release date: 2024-03-08

22235-81-0, endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetateRelated Search:

(endo,anti)-(±)-3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-isopropyl-8-methyl-8-azoniabicyclo[3.2.1]octane bromide DL-TROPIC ACID Tropic acid Ipratropium bromide 2-Oxo-(2H)-furo(2,3-h)-1-benzopyran A-(HYDROXYMETHYL)BENZENACETIC ACID METHYL ESTER Benzenepropanoic acid, b-oxo-a-phenyl-, methyl ester IpratropiuM BroMide IMpurity F (Mixture of DiastereoMers) endo-8-isopropyl-8-azabicyclo[3.2.1]octan-3-ol Atropine Impurity 4 Tropinone Atropine littorine (S)-Tropic acid Pseudotropine (1R,2R,4S,5S,7s,9S)-7-(((S)-3-hydroxy-2-phenylpropanoyl)oxy)-9-methyl-9-propyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-ium Atropine-d5 Atropine sulfate

endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate

N-Isopropylnoratropine

rac-(R*)-α-(Hydroxymethyl)benzeneacetic acid (1R,5S)-8-isopropyl-8-azabicyclo[3.2.1]octane-3α-yl ester

N-DesMethyl IpratropiuM

α-(HydroxyMethyl)benzeneacetic Acid (3-Endo)-8-(1-Methylethyl)-8-azabicyclo[3.2.1]- oct-3-yl Ester

α-(HydroxyMethyl)benzeneacetic Acid endo-8-(1-Methylethyl)-8- azabicyclo[3.2.1]oct-3-yl Ester

Ipratropium Bromide Impurity 13(Ipratropium EP Impurity E)

Ipratropium Impurity E

Ipratropium Bromide EP Impurity E

Benzeneacetic acid, α-(hydroxymethyl)-, (3-endo)-8-(1-methylethyl)-8-azabicyclo[3.2.1]oct-3-yl ester

Ipratropium Bromide Impurity 13（Ipratropium Bromide EP Impurity E）

endo-(1)-8-Aza-8-isopropylbicyclo(3.2.1)oct-3-yl (hydroxymethyl)phenylacetate

Ipratropium Bromide EP Impurity E (N-Isopropyl Noratropine)

N-Isopropyl Noratropine (Ipratropium Bromide EP Impurity E)

endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate

YB-M2

NIsopropylnoratropine,N Isopropylnoratropine

(1R,3r,5S)-8-Isopropyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropanoate (Ipratropium Impurity)

Ipratropium Bromide Impurity 13

(1R,3r,5S)-8-isopropyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropanoate

22235-81-0

2235-81-0

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