5-Chloroquinoxaline

5-Chloroquinoxaline Property

Melting point:

60-62 °C

Boiling point:

276.9±20.0 °C(Predicted)

Density 

1.349±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

-0.29±0.30(Predicted)

Appearance

Light yellow to yellow Solid

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H320Causes eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

5-Chloroquinoxaline Chemical Properties,Usage,Production

Synthesis

GENERAL METHODS: 3-Chlorophenyl-1,2-diamine (2.0 mmol) was mixed with the compound (CAS:131543-46-9, 2.0 mmol) and sulfated polyborate (10 wt%) was added. The reaction mixture was placed in an oil bath at 100 °C to stir the reaction and the progress of the reaction was monitored by thin layer chromatography (TLC). After completion of the reaction, the mixture was cooled to room temperature and the reaction was quenched with water. The organic phase was separated by extraction of the mixture with ethyl acetate (EtOAc). The crude product can be purified by recrystallization from ethanol or using silica gel column chromatography with silica as stationary phase and ethyl acetate: petroleum ether as mobile phase. The resulting 5-chloroquinoxaline, a known compound, was identified by determination of its melting point and 1H NMR and 13C NMR spectra, which were confirmed by comparing the spectral data with literature values.

References

[1] Journal of Chemical Sciences, 2017, vol. 129, # 2, p. 141 - 148
[2] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982, p. 357 - 364
[3] Organic Magnetic Resonance, 1980, vol. 14, # 4, p. 300 - 304