ChemicalBook > CAS DataBase List > PACAP 1-27

PACAP 1-27

Product Name
PACAP 1-27
CAS No.
127317-03-7
Chemical Name
PACAP 1-27
Synonyms
ovine;M-PACAP;PACAP-27;PACAP 1-27;PACAP-27 (human;PACAP (1-27) AMIDE;Human PACAP-(1-27);PACAP (1-27) (human;PACAP 27 AMIDE, OVINE;neurohypophysical hormone
CBNumber
CB7101106
Molecular Formula
C142H224N40O39S
Formula Weight
3147.61
MOL File
127317-03-7.mol
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PACAP 1-27 Property

Density 
1.45±0.1 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
5% acetic acid: 1mg/mL
form 
solid
color 
white
Water Solubility 
Soluble to 1 mg/ml in water
Sequence
His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-NH2
InChI
InChI=1/C142H224N40O39S/c1-16-75(10)113(179-108(191)66-156-120(201)102(63-109(192)193)173-135(216)104(67-183)176-119(200)88(146)62-84-65-153-70-157-84)139(220)174-101(58-80-28-18-17-19-29-80)133(214)182-114(79(14)186)140(221)175-103(64-110(194)195)132(213)178-106(69-185)136(217)172-100(61-83-39-45-87(189)46-40-83)131(212)177-105(68-184)134(215)164-93(34-27-54-155-142(151)152)126(207)170-98(59-81-35-41-85(187)42-36-81)129(210)163-92(33-26-53-154-141(149)150)124(205)161-89(30-20-23-50-143)122(203)165-94(47-48-107(147)190)127(208)166-95(49-55-222-15)121(202)159-78(13)118(199)180-111(73(6)7)137(218)167-91(32-22-25-52-145)123(204)162-90(31-21-24-51-144)125(206)171-99(60-82-37-43-86(188)44-38-82)130(211)169-97(57-72(4)5)128(209)160-76(11)116(197)158-77(12)117(198)181-112(74(8)9)138(219)168-96(115(148)196)56-71(2)3/h17-19,28-29,35-46,65,70-79,88-106,111-114,183-189H,16,20-27,30-34,47-64,66-69,143-146H2,1-15H3,(H2,147,190)(H2,148,196)(H,153,157)(H,156,201)(H,158,197)(H,159,202)(H,160,209)(H,161,205)(H,162,204)(H,163,210)(H,164,215)(H,165,203)(H,166,208)(H,167,218)(H,168,219)(H,169,211)(H,170,207)(H,171,206)(H,172,217)(H,173,216)(H,174,220)(H,175,221)(H,176,200)(H,177,212)(H,178,213)(H,179,191)(H,180,199)(H,181,198)(H,182,214)(H,192,193)(H,194,195)(H4,149,150,154)(H4,151,152,155)/t75-,76-,77-,78-,79+,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,111-,112-,113-,114-/s3
InChIKey
RZGBUJXSKLDAFE-XVTUQGJWNA-N
SMILES
[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]([C@H](O)C)NC(=O)[C@@H](NC(=O)[C@H]([C@@H](C)CC)NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC1N=CNC=1)CC1=CC=CC=C1)CC1C=CC(O)=CC=1)(C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](C(=O)N)CC(C)C)CC1C=CC(O)=CC=1)CC1=CC=C(O)C=C1 |&1:0,4,15,21,25,31,39,40,46,50,51,62,70,76,102,113,122,131,139,144,151,160,169,173,181,186,191,198,r|
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
05-23-2151
Product name
PACAP 27 Amide, Ovine - CAS 127317-03-7 - Calbiochem
Purity
Increases cAMP levels in a dose-dependent manner (EC?? = 4.7 nM).
Packaging
.5mg
Price
$418
Updated
2025/07/31
Sigma-Aldrich
Product number
05-23-2151
Product name
PACAP 27 Amide, Ovine
Purity
Increases cAMP levels in a dose-dependent manner (EC?? = 4.7 nM).
Packaging
0.5MG
Price
$405
Updated
2024/03/01
Tocris
Product number
1183
Product name
PACAP1-27
Packaging
100U
Price
$161
Updated
2021/12/16
Usbiological
Product number
P1775-01F
Product name
PACAP-27
Packaging
1mg
Price
$350
Updated
2021/12/16
TRC
Product number
P132050
Product name
PACAP1-27
Packaging
0.5mg
Price
$545
Updated
2021/12/16
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PACAP 1-27 Chemical Properties,Usage,Production

Chemical Properties

This product is made from the posterior lobe of the pituitary gland of pigs, cows, sheep and other animals by dehydration, drying and fine grinding. It contains oxytocin (oxytocin, oxytocin, about 20 units) and a small amount of vasopressin (vasopressin, 0.5 units), both of which are very similar in structure, and both are natriuretic peptides containing disulfide bonds. The powder is a pale yellow or pale gray non-crystalline powder with a peculiar odor and is practically insoluble in water. It has the effect of excitation of the uterus and promotion of milk discharge, and the vasodilatation of blood vessels when the dose of contraction is large, but the vasoconstriction of blood vessels when the dose of ascending hormone is large, as well as the diuretic effect.

Uses

Pituitary Adenylate Cyclase-Activating Polypeptide 1-27 (PACAP 1-27) is a neuropeptide that stimulates adenylyl cyclase.

Biological Functions

PACAP 1-27 is an endogenous neuropeptide and is the C-terminally truncated form of PACAP 38. PACAP 27 has considerable homology with vasoactive intestinal peptide (VIP) but is >100 fold more potent than VIP as an agonist of the PAC1 receptor. PACAP 27 functions in the control of anterior pituitary hormone secretion, vasodilation, adrenaline secretion, insulin secretion and immunosuppression.

Biological Activity

PACAP 1-27, also known as PACAP 27 Amide, is an endogenous neuropeptide showing considerable homology with vasoactive intestinal peptide (VIP). Potently stimulates adenylyl cyclase.

in vivo

The inhibitory effect of pituitary adenylate cyclase activating polypeptide (PACAP (1-27), human, ovine, rat) on the increase in total pulmonary resistance (RL) causes either by allergen or histamine in anaesthetized, ventilated guinea-pigs is studied. PACAP (1-27), human, ovine, rat given via i.v. infusion (0.045-4.5 nmol/kg/min) dose-dependently reduces the increase in RL caused by inhaled ovalbumin and histamine. At the highest dose, PACAP (1-27), human, ovine, rat prevented the increase in RL caused by ovalbumin and histamine completely. Infusion of PACAP (1-27), human, ovine, rat and the β2-adrenoceptor agonist, salbutamol (0.045-4.5 nmol/kg/min) inhibit the increase in RL similarly, but salbutamol increases the heart rate more than PACAP (1-27), human, ovine, rat[3].

storage

Store at -20°C

PACAP 1-27 Preparation Products And Raw materials

Raw materials

Oxytocin Nisin Α-protein

Preparation Products

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PACAP 1-27 Suppliers

China 115 Europe 1 France 1 Germany 4 Japan 1 Switzerland 2 United Kingdom 2 United States 16 Global 142
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View Lastest Price from PACAP 1-27 manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
PACAP 1-27 127317-03-7
Price
US $2.00-5.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-06-17
Shanghai Getian Industrial Co., LTD
Product
PACAP 1-27 127317-03-7
Price
US $23.00-17.00/box
Min. Order
1box
Purity
99%
Supply Ability
100000box
Release date
2024-05-07
Zhuozhou Wenxi import and Export Co., Ltd
Product
127317-03-7 127317-03-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

127317-03-7, PACAP 1-27Related Search:

PACAP 6-38 PACAP38 PITUITARY ADENYLATE CYCLASE ACTIVATING DL-THYROXINE HLH Pregnant mare serum gonadotropin Follicle stimulating hormone Follicle-stimulating hormone TSH Corticotropin Testosterone Parathyroid CORTISONE Hydrocortisone Inositol Calcitonin Vasopressin H-HIS-SER-ASP-GLY-ILE-PHE-THR-ASP-SER-TYR-SER-ARG-TYR-ARG-LYS-GLN-MET-ALA-VAL-LYS-LYS-TYR-LEU-ALA-ALA-VAL-LEU-GLY-LYS-ARG-TYR-LYS-GLN-ARG-VAL-LYS-ASN-LYS-LYS(BIOTIN)-NH2

  • HSDGIFTDSYSRYRKQMAVKKYLAAVL-NH2
  • HIS-SER-ASP-GLY-ILE-PHE-THR-ASP-SER-TYR-SER-ARG-TYR-ARG-LYS-GLN-MET-ALA-VAL-LYS-LYS-TYR-LEU-ALA-ALA-VAL-LEU-NH2
  • H-HIS-SER-ASP-GLY-ILE-PHE-THR-ASP-SER-TYR-SER-ARG-TYR-ARG-LYS-GLN-MET-ALA-VAL-LYS-LYS-TYR-LEU-ALA-ALA-VAL-LEU-NH2
  • [ARG14,20,21, LEU16] PACAP (1-27), HUMAN, OVINE, RAT
  • [ARG14,20,21, LEU16] PITUITARY ADENYLATE CYCLASE ACTIVATING PEPTIDE (1-27), HUMAN, OVINE, RAT
  • ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE-27 OVINE
  • ADENYLATE CYCLASE ACTIVATING PEPTIDE-27
  • pituitary adenylate cyclase activating*polypeptid
  • pituitary adenylate cyclase activating polypeptide-27 ovine
  • powdered posterior pitultary
  • HIS-SER-ASP-GLY-ILE-PHE-THR-ASP-SER-TYR-SER-ARG-TYR-ARG-ARG-GLN-LEU-ALA-VAL-ARG-ARG-TYR-LEU-ALA-ALA-VAL-LEU-NH2
  • HIS-SER-ASP-GLY-ILE-PHE-THR-ASP-SER-TYR-SER-ARG-TYR-ARG-LYS-GLN-MET-ALA-VAL-LYS-LYS-TYR-LEU-ALA-ALA-VAL-LEU-GLY-LYS-ARG-TYR-LYS-GLN-ARG-VAL-LYS-ASN-LYS-NH2: HSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNK-NH2
  • PACAP-38 (1-27) aMide (huMan, Mouse, ovine, porcine, rat), Pituitary Adenylate Cyclase Activating Polypeptide-27 (huMan, Mouse, ovine, porcine, rat)
  • PITUITARY ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE 27 AMIDE, OVINE
  • PITUITARY ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE-27 (HUMAN, MOUSE, OVINE, PORCINE, RAT)
  • PITUITARY ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE
  • PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE 1-27
  • PITUITARY ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE (1-27) AMIDE (HUMAN, OVINE, RAT)
  • PITUARY ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE 27 (HUMAN, 1-27 AMIDE) OVINE, RAT
  • PITUITARY ADENYLATE CYCLASE-ACTIVATING PEPTIDE (1-27)
  • PITUITARY ADENYLATE CYCLASE ACTIVATING PEPTIDE (1-27), HUMAN, OVINE, RAT
  • PACAP-27
  • PACAP-38 (1-27) AMIDE (HUMAN, MOUSE, OVINE, PORCINE, RAT)
  • PACAP 27 AMIDE, OVINE
  • PACAP27 (HUMAN, 1-27 AMIDE) (OVINE, RAT)
  • PACAP-27 (HUMAN, MOUSE, OVINE, PORCINE, RAT)
  • PACAP-27 (HUMAN, OVINE, RAT)
  • PACAP 1-27
  • PACAP (1-27) AMIDE
  • PACAP (1-27), AMIDE, HUMAN, OVINE, RAT
  • PACAP (1-27), HUMAN, OVINE, RAT
  • PACAP (1-27) (HUMAN, SHEEP, RAT)
  • PACAP-PITUITARY ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE (HUMAN, OVINE, RAT)
  • M-PACAP
  • PACAP 27 Amide, Ovine - CAS 127317-03-7 - Calbiochem
  • L-Leucinamide, L-histidyl-L-seryl-L-α-aspartylglycyl-L-isoleucyl-L-phenylalanyl-L-threonyl-L-α-aspartyl-L-seryl-L-tyrosyl-L-seryl-L-arginyl-L-tyrosyl-L-arginyl-L-lysyl-L-glutaminyl-L-methionyl-L-alanyl-L-valyl-L-lysyl-L-lysyl-L-tyrosyl-L-leucyl-L-alanyl-L-alanyl-L-valyl-
  • Pituitary adenylatecyclase-activating peptide-27 (human) (9CI)
  • H-HIS-SER-ASP-GLY-ILE-PHE-THR-ASP-SER-TYR-SER-ARG-TYR-ARG-LYS-GLN-MET-ALA-VAL-LYS-LYS-TYR-LEU-ALA-ALA-VAL-LEU-NH2 USP/EP/BP
  • ovine
  • PACAP-27 (human
  • porcine rat) trifluoroacetate salt
  • Human PACAP-(1-27)
  • neurohypophysical hormone
  • PACAP (1-27) (human
  • Pacpa-27 (human, mouse, ovine, porcine, rat)
  • PACAP (1-27), amide, human, ovine, rat - 0.5 mg
  • PACAP27 (Human, 1-27 Amide) (0.5 mg vial)
  • Pituitary adenylate cyclase-activating peptide：PACAP(1-27), human, ovine, rat
  • 127317-03-7
  • C43H66O12N12S2
  • C142H224N40O39S
  • Cyclic Nucleotide Metabolism
  • G Proteins and Cyclic Nucleotides
  • Cell Biology
  • Cell Signaling and Neuroscience
  • BioChemical
  • Adenylyl Cyclase Activators
  • Peptide