ChemicalBook > CAS DataBase List > TROXACITABINE

TROXACITABINE

Product Name: TROXACITABINE
CAS No.: 145918-75-8
Chemical Name: TROXACITABINE
Synonyms: CS-150;L-Oddc;SPD 758;Bch 4556;(-)-Occc;Troxatyl;(-)-Bch 204;TROXACITABINE;α-L-Dioxolane-C;Lamivudine Impurity I
CBNumber: CB71011675
Molecular Formula: C8H11N3O4
Formula Weight: 213.19
MOL File: 145918-75-8.mol

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TROXACITABINE Property

Melting point:: 176-177°
alpha: D25 -38.33° (c = 0.43 in MeOH).
Boiling point:: 422.5±55.0 °C(Predicted)
Density: 1.71±0.1 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 14.83±0.10(Predicted)
color: White to Off-White
Stability:: Hygroscopic
InChI: InChI=1S/C8H11N3O4/c9-5-1-2-11(8(13)10-5)6-4-14-7(3-12)15-6/h1-2,6-7,12H,3-4H2,(H2,9,10,13)/t6-,7-/m0/s1
InChIKey: RXRGZNYSEHTMHC-BQBZGAKWSA-N
SMILES: C1(=O)N([C@@H]2CO[C@H](CO)O2)C=CC(N)=N1

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: T805580
Product name: Troxacitabine
Packaging: 0.5mg
Price: $335
Updated: 2021/12/16

TRC

Product number: T805580
Product name: Troxacitabine
Packaging: 2.5mg
Price: $1490
Updated: 2021/12/16

Usbiological

Product number: 296507
Product name: Troxacitabine
Packaging: 10mg
Price: $3787
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0005342
Product name: TROXACITABINE
Purity: 95.00%
Packaging: 1G
Price: $8805.3
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0005342
Product name: TROXACITABINE
Purity: 95.00%
Packaging: 10MG
Price: $1067.22
Updated: 2021/12/16

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TROXACITABINE Chemical Properties,Usage,Production

Uses

Troxacitabine is a nucleoside analogue with potential anticancer activity. Troxacitabine have been studied in patients with refractory lymphoproliferative diseases.

Definition

ChEBI: Troxacitabine is a nucleobase-containing molecular entity and a carbohydrate derivative.

in vivo

Troxacitabine is highly active against the Panc-01 model, with TGI levels of 88.5% and 84.3% at the 10 and 25 mg/kg doses, respectively. The mean final tumor weights for animals given troxacitabine are also significantly smaller compared with vehicle controls. Troxacitabine has less activity against the MiaPaCa model^[3]. Troxacitabine is very effective in human RCC tumor xenograft models, including CAM-i, A498, RXF-393, and SN12C carcinomas. Very good responses are ob served in animals bearing CAM-i, A498, and RXF-393 RCC tumors given i.p. doses of 10, 25, and 50 mg/kg twice a day for 5 days^[2].

TROXACITABINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from TROXACITABINE manufacturers

Hangzhou Huarong Pharm Co., Ltd.

Product: 4-amino-1-((2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl)pyrimidin-2(1H)-one 145918-75-8
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 99%
Supply Ability: 10KG
Release date: 2021-09-17

Career Henan Chemical Co

Product: TROXACITABINE 145918-75-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95--99%
Supply Ability: 1ton
Release date: 2020-01-03

145918-75-8, TROXACITABINERelated Search:

4-amino-1-((2R,3R,5S)-2-(hydroxymethyl)-3-oxido-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one Cytosine lamivudine sulfoxide Salicylic acid Lamivudine Aids004768 Lamivudine EP Impurity A lignocaine N-oxide 4-(HYDROXYMETHYL)BENZONITRILE (2R,5R)-5-Hydroxy-1,3-oxathiolane-2-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester Lamivudine Impurity 9 Lamivudine impurity 6 (1r,2s,5r)-2-Isopropyl-5-Methylcyclohexyl-5-Hydroxy-1,3oxathiolane-2-Carboxylate Gemcitabine Antazoline Uracil ent-LaMivudine Lamivudine EP Impurity B

TROXACITABINE

TROXACITABINE,2(1H)-PYRIMIDINONE, 4-AMINO-1-(2-(HYDROXYMETHYL)-1,3-DIOXOLAN-4-YL)-, (2S-CIS)-

4-Amino-1-[(2S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]pyrimidin-2-one

(-)-Bch 204

CS-150

Lamivudine Impurity I (Troxacitabine)

4-amino-1-[(2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]-1,2-dihydropyrimidin-2-one

(-)-Occc

2(1H)-Pyrimidinone, 4-amino-1-((2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl)-

2(1H)-Pyrimidinone, 4-amino-1-(-2-(hydroxymethyl)-1,3-dioxolan-4-yl)-, (2S-cis)-

Bch 4556

L-Oddc

Troxatyl

Troxacitabine (SGX-145)

SPD 758

α-L-Dioxolane-C

Lamivudine Impurity I

4-amino-1-((2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl)pyrimidin-2(1H)-one

Lamivudine EP Impurity I

Lamivudine EP Impurity I (Troxacitabine)

Troxacitabine(BCH4556)

4-amino-1-((2RS,4RS)-2-(hydroxymethyl)-1,3-dioxolan-4-yl)pyrimidin-2(1H)-one

4-amino-1-(2-(hydroxymethyl)-1,3-dioxolan-4-yl)pyrimidin-2(1H)-one

145918-75-8