ChemicalBook > CAS DataBase List > SUGAMMADEX
SUGAMMADEX
- Product Name
- SUGAMMADEX
- CAS No.
- 343306-71-8
- Chemical Name
- SUGAMMADEX
- Synonyms
- SugaMMadex SodiuM;Bridion;Sugammagex;Org 25969;SUGAMMADEX;Shu Glucose;shugen glucose;Unii-361lpm2T56;Sugammadex [inn];Suggmadex Sodium
- CBNumber
- CB71011756
- Molecular Formula
- C72H112O48S8
- Formula Weight
- 2002.15
- MOL File
- 343306-71-8.mol
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SUGAMMADEX Property
- Melting point:
- >208°C (dec.)
- Density
- 1.559±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Aqueous Acid (Slightly), Water (Slightly, Sonicated)
- pka
- 3.42±0.10(Predicted)
- form
- Solid
- color
- White to Pale Beige
- Stability:
- Hygroscopic
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N-Bromosuccinimide Price
TRC
- Product number
- C246000
- Product name
- 6A,6B,6C,6D,6E,6F,6G,6H-octakis-S-(2-carboxyethyl)-6A,6B,6C,6D,6E,6F,6G,6H-octathio-γ-Cyclodextrin
- Packaging
- 50mg
- Price
- $200
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- API0027459
- Product name
- SUGAMMADEX
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $4551.66
- Updated
- 2021/12/16
Arctom
- Product number
- AS007960
- Product name
- Sugammadex
- Packaging
- 25mg
- Price
- $292
- Updated
- 2021/12/16
Ambeed
- Product number
- A100281
- Product name
- Sugammadex
- Purity
- 98%
- Packaging
- 1g
- Price
- $795
- Updated
- 2021/12/16
Ambeed
- Product number
- A100281
- Product name
- Sugammadex
- Purity
- 98%
- Packaging
- 1mg
- Price
- $19
- Updated
- 2021/12/16
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SUGAMMADEX Chemical Properties,Usage,Production
Description
Sugammadex is a selective relaxant binding agent indicated for reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide during surgery in adults. Rocuronium bromide and vecuronium bromide are neuromuscular blocking medications that cause temporary paralysis and are especially useful for general anesthesia, ventilation, or tracheal intubation that patients may require for surgery. Sugammadex provides a new treatment option to reverse the effects of those medications and possibly help patients recover sooner post-surgery. Sugammadex (brand name Bridion) is marketed by Merck Sharp and Dohme, and was approved by the United States FDA on December 15, 2015.
Uses
6A,6B,6C,6D,6E,6F,6G,6H-octakis-S-(2-carboxyethyl)-6A,6B,6C,6D,6E,6F,6G,6H-octathio-γ-Cyclodextrin, also known as Sugammadex, is used to reverse postoperative residual neuromuscular blockade.
Uses
Reversal agent for neuromuscular blocking drugs.
Definition
ChEBI: An octasaccharide derivative that is gamma-cyclodextrin in which all eight primary hydroxy groups are replaced by 2-(carboxyethyl)sulfanyl groups. Used (as the octasodium salt) for reversal of neuromuscular blockade induced by rocuronium and vecuronium in adults undergoing surgery.
Synthesis
Bromination of |?-cyclodexdrin 127 with the Vilsmeier-Haack reagent prepared by reaction of bromine with triphenylphospine in DMF gave the per-6-bromo-|?-cyclodextrin 128 in 95-98% yield. Nucleophilic displacement of the bromines of 128 with methyl 3-mercaptopropionate (129) and cesium carbon-ate at 50??C in DMF gave 6-perdeoxy-6-per(2-methoxycarbonylethyl) thio-|?-cyclodextrin 130 as a white powder. Saponification of the esters of 130 was accomplished by reaction with aqueous sodium hydroxide solution to provide sugammadex (XVII) as a glassy solid in 52% yield for the 2 steps.
SUGAMMADEX Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from SUGAMMADEX manufacturers
WUHAN FORTUNA CHEMICAL CO., LTD
- Product
- Sugammadex 343306-71-8
- Price
- US $0.00/Kg/Bag
- Min. Order
- 1KG
- Purity
- 99%min HPLC
- Supply Ability
- 100kgs
- Release date
- 2021-08-26
Hebei Mingeng Biotechnology Co., Ltd
- Product
- Sugammadex 343306-71-8
- Price
- US $120.00/kg
- Min. Order
- 10kg
- Purity
- 99%
- Supply Ability
- 500kg/month
- Release date
- 2022-05-05
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- sugammadex 343306-71-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11
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