MECLOFENAMATE SODIUM

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MECLOFENAMATE SODIUM

Product Name: MECLOFENAMATE SODIUM
CAS No.: 6385-02-0
Chemical Name: MECLOFENAMATE SODIUM
Synonyms: ci583;C02996;Movens;meclomen;Meclonax;Meclofenamate;SODIUM MECLOFENAMATE;sodiummeclophenamate;MECLOFENAMATE SODIUM;MECLOFENAMATESODIUM,USP
CBNumber: CB7102365
Molecular Formula: C14H10Cl2NO2.Na
Formula Weight: 318.13
MOL File: 6385-02-0.mol

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MECLOFENAMATE SODIUM Property

Melting point:: 287-291 °C
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: White solid.
color: White to Off-White
Water Solubility: Soluble in water at 50mg/ml. Also soluble in DMF, DMSO or ethanol
Merck: 14,5779
Stability:: Hygroscopic

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Safety

WGK Germany: 3
RTECS: CB2975500
HS Code: 2922498050

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M4531
Product name: Meclofenamic acid sodium salt
Packaging: 1g
Price: $56.6
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1377803
Product name: Meclofenamate Sodium
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 500mg
Price: $467
Updated: 2024/03/01

TCI Chemical

Product number: M1269
Product name: Sodium Meclofenamate
Packaging: 1G
Price: $63
Updated: 2024/03/01

TCI Chemical

Product number: M1269
Product name: Sodium Meclofenamate Hydrate
Purity: >98.0%(HPLC)(N)
Packaging: 10g
Price: $372
Updated: 2024/03/01

Alfa Aesar

Product number: J60484
Product name: Meclofenamic acid sodium salt, 99+%
Packaging: 1g
Price: $43.65
Updated: 2024/03/01

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MECLOFENAMATE SODIUM Chemical Properties,Usage,Production

Description

Meclofenamate is a time-dependent, non-specific competitive inhibitor of COX-1 and -2. The IC₅₀ values for inhibition of human recombinant COX-1 and -2 are 1.5 and 9.7 μM, respectively for instantaneous inhibition. However, the IC₅₀ is much lower if pre-incubated with the enzyme.

Originator

Meclomen,Warner Lambert,US,1980

Uses

antiinflammatory, antipyretic

Uses

Meclofenamate Sodium is an NSAID used in the treatment of chronic pain.

Indications

Meclofenamate sodium (Meclomen) is prescribed for rheumatoid arthritis and osteoarthritis. The fenamates show no clear superiority in antiinflammatory activity and may produce more adverse effects than other NSAIDs.

Definition

ChEBI: An organic sodium salt derived from meclofenamic acid. Its monohydrate is used for the treatment of dysmenorrhoea (painful periods), osteoarthritis and rheumatoid arthritis.

Manufacturing Process

A mixture consisting of 22.7 g potassium o-bromobenzoate, 16.6 g 2,6- dichloro-3-methylaniline, 12 ml N-ethylmorpholine, 60 ml diethylene glycol dimethyl ether, and 1.0 g anhydrous cupric bromide is heated in a nitrogen atmosphere at 145°C to 155°C for 2 hours. The reaction mixture is diluted with 60 ml diethylene glycol dimethyl ether and acidified with 25 ml concentrated hydrochloric acid. The acidic mixture is diluted with 100 ml of water and the liquid phase decanted from the insoluble oil. The insoluble oil is stirred with methanol and the crystalline N-(2,6-dichloro-3-methylphenyl) anthranilic acid which separates is collected and washed with methanol. The product, after recrystallization from acetone-water mixture, melts at 248°C to 250°C.

brand name

Meclomen (Parke-Davis).

Therapeutic Function

Antiinflammatory

General Description

Meclofenamate sodium (Meclomen) is available for use inthe treatment of acute and chronic RA, OA, and primarydysmenorrhea. It is metabolized in a similar manner tomefenamic acid discussed above, thus a similar restriction isalso applied to meclofenamate. The most significant side effectsare GI, including diarrhea.

Pharmacokinetics

Meclofenamate sodium is rapidly and almost completely absorbed following oral administration, reaching peak plasma levels within 2 hours. It is highly bound to plasma proteins (99%) and has a plasma half-life of 2 to 4 hours. Metabolism involves oxidation of the methyl group, aromatic hydroxylation, monodehalogenation, and conjugation. Urinary excretion accounts for approximately 75% of the administered dose. The major metabolite is the product of 3′-methyl oxidation and has been shown to possess anti-inflammatory activity.

Clinical Use

Meclofenamate sodium is indicated for the relief of mild to moderate pain, the acute and chronic treatment of rheumatoid arthritis and osteoarthritis, the treatment of primary dysmenorrhea, and the treatment of idiopathic, heavy menstrual blood loss.

MECLOFENAMATE SODIUM Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from MECLOFENAMATE SODIUM manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: SodiuM MeclofenaMate Monohydrate 6385-02-0
Price: US $1.00-1.00/KG
Min. Order: 1g
Purity: 99%
Supply Ability: 50tons
Release date: 2020-04-29

Dideu Industries Group Limited

Product: MECLOFENAMATE SODIUM 6385-02-0
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-06-15

6385-02-0, MECLOFENAMATE SODIUMRelated Search:

MCPA SODIUM CLOFENAMIC ACID SODIUM ANTHRANILATE Meclofenamic acid MECLOFENAMATE SODIUM N-Phenylanthranilic acid 2,6-DICHLORODIPHENYLAMINE 2-Chloro-5-methylaniline 2,6-Dichloro-3-methylaniline 2-Chloro-m-toluidine. N-(2-CHLOROPHENYL)ANTHRANILIC ACID N-(3-METHYLPHENYL)ANTHRANILIC ACID 2-[(2-Chlorophenyl)amino]-benzaldehyde 2-[(2,6-dichlorophenyl)amino]benzoicacid (2-CHLORO-PHENYL)-PHENYL-AMINE (2-(2,6-DICHLOROANILINO)PHENYL) METHANOL 2-(2,6-Dichloroanilino) benzaldehyde MECLOFENAMATE SODIUM USP(CRM STANDARD)

MECLOFENAMIC ACID SODIUM SALT MONOHYDRATE

Sodium Meclofenamate Monohydrate

C02996

sodium 2-(2,6-dichloro-3-methylanilino)benzoate hydrate

SODIUM MECLOFENAMATE

meclofenamic acid sodium

MECLOFENAMIC ACID SODIUM SALT 99%

Meclofenamate

MECLOFENAMATESODIUM,USP

sodium meclofenamate (anhydrous)

sodium2-((2,6-dichloro-3-methylphenyl)amino)benzoate

sodiummeclophenamate

MECLOFENAMATE SODIUM

MECLOFENAMATE SODIUM HYDRATE

MECLOFENAMATE SODIUM SALT

MECLOFENAMIC ACID SODIUM SALT

2-[(2,6-DICHLORO-3-METHYLPHENYL)AMINO]-BENZOIC ACID, MONOSODIUM SALT

2-[(2,6-DICHLORO-3-METHYLPHENYL)AMINO]BENZOIC ACID SODIUM SALT

sodium,2-(2,6-dichloro-3-methylanilino)benzoate

2-((2,6-dichloro-3-methylphenyl)amino)-benzoicacimonosodiumsalt

ci583

meclomen

n-(2,6-dichloro-m-tolyl)-anthranilicacimonosodiumsalt

Benzoic acid, 2-[(2,6-dichloro-3-Methylphenyl)aMino]-, sodiuM salt

Meclofenamate Sodium (500 mg)

2-[(2,6-Dichloro-3-methylphenyl)amino]benzoic Acid Sodium Salt Meclofenamic Acid Sodium Salt

SodiuM MeclofenaMate&nbsp

Benzoic acid, 2-[(2,6-dichloro-3-methylphenyl)amino]-, sodium salt (1:1)

2-[(2,6-dichloro-3-methylphenyl)amino]-benzoic acid, sodium salt (1:1)

Sodium Meclofenamate Hydrate

SodiumMeclofenamateMonohydrate&gt

Meclonax

Movens

2-[(2,6-Dichloro-3-methylphenyl)amino]benzoic acid sodium salt monohydrate

MECLOFENAMATE SODIUM USP/EP/BP

Meclofenamate Sodium (Meclofenamic acid sodium)

Meclofenamate Sodium (1377803)

Endogenous Metabolite,Meclofenamate,Inhibitor,Meclofenamic acid sodium,inhibit,Meclofenamic acid,Gap Junction Protein

Sodium Meclofenamate Monohydrate, ≥ 98.0%

6385-02-0

6358-02-0

C14H10Cl2NO2NaH2O

C14H10Cl2NNaO2xH2O

C14H11Cl2NNaO2

C14H10Cl2NNaO2H2O

Lipoxygenase (5-) and cyclooxygenase

L to O

Enzyme Inhibitors

Enzyme Inhibitors by Enzyme

Enzymes, Inhibitors, and Substrates

BioChemical

Biochemicals and Reagents

MECLOMEN