Meclofenamic acid
- Product Name
- Meclofenamic acid
- CAS No.
- 644-62-2
- Chemical Name
- Meclofenamic acid
- Synonyms
- Arquel;INF 4668;Meclofen;NSC 95309;Meclorfenamic;meclofenamicaci;Meclofenamic acid;Meclophenamic acid;C14804500 MeclofenamiCacid;Meclofenamic acid USP/EP/BP
- CBNumber
- CB7875562
- Molecular Formula
- C14H11Cl2NO2
- Formula Weight
- 296.15
- MOL File
- 644-62-2.mol
Meclofenamic acid Property
- Melting point:
- 257-259°C
- Boiling point:
- 399.4±42.0 °C(Predicted)
- Density
- 1.3567 (rough estimate)
- refractive index
- 1.6070 (estimate)
- storage temp.
- Refrigerator
- solubility
- Chloroform (Slightly), Methanol (Slightly, Heated)
- form
- Solid
- pka
- pKa 4.0 (Uncertain)
- color
- Off-White to Light Orange
- EPA Substance Registry System
- Benzoic acid, 2-[(2,6-dichloro-3-methylphenyl)amino]- (644-62-2)
N-Bromosuccinimide Price
- Product number
- M202750
- Product name
- MeclofenamicAcid
- Packaging
- 5mg
- Price
- $185
- Updated
- 2021/12/16
- Product number
- M202750
- Product name
- MeclofenamicAcid
- Packaging
- 25mg
- Price
- $850
- Updated
- 2021/12/16
- Product number
- HCH0037298
- Product name
- MECLOFENAMIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $756.25
- Updated
- 2021/12/16
- Product number
- HCH0037298
- Product name
- MECLOFENAMIC ACID
- Purity
- 95.00%
- Packaging
- 50MG
- Price
- $1732.5
- Updated
- 2021/12/16
- Product number
- CSN24828
- Product name
- Meclofenamicacid
- Packaging
- 25mg
- Price
- $882
- Updated
- 2021/12/16
Meclofenamic acid Chemical Properties,Usage,Production
Chemical Properties
White Crystalline Solid
Originator
Meclomen,Warner Lambert,US,1980
Uses
Meclofenamic acid is used for the same conditions as flufenamic acid.
Uses
Anti-inflammatory; antipyretic
Definition
ChEBI: An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,6-dichloro-3-methylphenyl group. A non-steroidal anti-inflammatory drug, it is used as the sodium salt for the treatment of dysmenorrhoe (painful periods), osteoarthritis and rheumatoid arthritis.
Manufacturing Process
A mixture consisting of 22.7 g potassium o-bromobenzoate, 16.6 g 2,6- dichloro-3-methylaniline, 12 ml N-ethylmorpholine, 60 ml diethylene glycol dimethyl ether, and 1.0 g anhydrous cupric bromide is heated in a nitrogen atmosphere at 145°C to 155°C for 2 hours. The reaction mixture is diluted with 60 ml diethylene glycol dimethyl ether and acidified with 25 ml concentrated hydrochloric acid. The acidic mixture is diluted with 100 ml of water and the liquid phase decanted from the insoluble oil. The insoluble oil is stirred with methanol and the crystalline N-(2,6-dichloro-3-methylphenyl) anthranilic acid which separates is collected and washed with methanol. The product, after recrystallization from acetone-water mixture, melts at 248°C to 250°C.
brand name
Meclomen (Parke-Davis, Portugal, USA), Meclodol (Parke Davis, Italy), Stadium (Menarini, Belgium).
Therapeutic Function
Antiinflammatory
Clinical Use
Meclofenamat is a nonsteroidal anti-inflammatory drug used for the treatment of mild to moderate pain, musculoskeletal, and joint disorders like rheumatoid arthritis and osteoarthritis as well as dysmenorrhoea. Meclofenamate inhibits COX-1 and COX-2 and modifies ion channels.
Side effects
Meclofenamic acid is available as its sodium salt hydrate. This drug is indicated for the relief of acute and chronic rheumatoid arthritis and osteoarthritis. Gastrointestinal distress, including diarrhea, nausea, vomiting, and abdominal pain, is the most commonly reported adverse effect.
Synthesis
Meclofenamic acid, N-(2,6-dichloro-m-tolyl)anthranylic acid (3.2.20), is synthesized analogous to flufenamic acid, by the reaction of potassium salt of 2-bromobenzoic acid with 2,6-dichloro-3-methylaniline in the presence of copper (II) bromide in a mixture of N-ethylmorpholine and diglyme [82,83].
Toxics Screening Level
The ITSL for meclofenamic acid has been changed from 0.04 μg/m3 to 0.1 μg/m3 based on an annual averaging time.
Meclofenamic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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