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ACETYLENEDICARBOXAMIDE

Product Name
ACETYLENEDICARBOXAMIDE
CAS No.
543-21-5
Chemical Name
ACETYLENEDICARBOXAMIDE
Synonyms
Renamycin;Lenamycin;Aquamycin;4-Dioxane-2;2-BUTYNEDIAMIDE;but-2-ynediaMide;ACETYLENEDICARBOXAMIDE;1,2-Ethynedicarboxamide;Acetylendicarbonsaeureamid;acetylenedicarboxylicaciddiamide
CBNumber
CB7103786
Molecular Formula
C4H4N2O2
Formula Weight
112.09
MOL File
543-21-5.mol
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ACETYLENEDICARBOXAMIDE Property

Melting point:
179 °C
Boiling point:
209.98°C (rough estimate)
Density 
1.4421 (rough estimate)
refractive index 
1.4610 (estimate)
storage temp. 
Store at -20°C
solubility 
DMF: 10 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2) (1:7): 0.12 mg/ml
form 
Fine Crystalline Powder
pka
13.01±0.50(Predicted)
color 
Cream to beige
EPA Substance Registry System
2-Butynediamide (543-21-5)
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Safety

Hazard Codes 
T
Risk Statements 
25-21
Safety Statements 
45-36/37-28A
HS Code 
29241900
Toxicity
LD50 i.v. in mice: 11 mg/kg (Suzuki)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
23637
Product name
Cellocidin
Purity
≥95%
Packaging
5mg
Price
$97
Updated
2024/03/01
Cayman Chemical
Product number
23637
Product name
Cellocidin
Purity
≥95%
Packaging
10mg
Price
$156
Updated
2024/03/01
Cayman Chemical
Product number
23637
Product name
Cellocidin
Purity
≥95%
Packaging
25mg
Price
$340
Updated
2024/03/01
Cayman Chemical
Product number
23637
Product name
Cellocidin
Purity
≥95%
Packaging
50mg
Price
$631
Updated
2024/03/01
TRC
Product number
C255953
Product name
Cellocidin
Packaging
5mg
Price
$305
Updated
2021/12/16
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ACETYLENEDICARBOXAMIDE Chemical Properties,Usage,Production

Description

Cellocidin is an antibiotic originally isolated from S. chibaensis. It is active against various bacterial strains including M. tuberculosis and against the trypanosomes T. brucei and T. rhodesiense (IC50s = 150 and 30 ng/ml, respectively). It inhibits proliferation of LCL1 and LCL2 cells transformed by Epstein-Barr virus (EBV), activates the c-Myc and NF-κB pathways in BC3 and LCL1 cells, and induces necrotic cell death in B cells infected with gammaherpes virus. Cellocidin (100-200 ppm) is protective against bacterial leaf blight in rice plants and inhibits α-ketoglutarate oxidation in X. oryzae, the bacterium that causes leaf blight, when used at a concentration of 1 ppm, suggesting that it inhibits the citric acid cycle. Formulations containing cellocidin have been used as agricultural pesticides.

Chemical Properties

CREAM TO BEIGE FINE CRYSTALLINE POWDER

Uses

Cellocidin is a small neutral alkyne produced by a number of Streptomyces species, first discovered by Suzuki and colleagues in 1958. Cellocidin has a broad antibacterial, antifungal and antitumor profile due to its ability to react with endogenous thiols like cysteine and glutathione. Cellocidin occurs as a weak active in many bioassays using actinomycete crude extracts and is thus a useful standard for chemical and bioassay dereplication.

Definition

ChEBI: A dicarboxylic acid diamide resulting from the formal condensation of both of the carboxy groups of butynedioic acid with ammonia. An antibacterial agent produced by Streptomyces chibaensis.

Purification Methods

Acetylenedicarboxamide crystallises from MeOH and H2O [m 190-192o(dec) as hemihydrate]. When prepared from the ester + NH3 it has m 213o(dec). Also a melting point of 290-292o(dec) has been reported. [Saggimo J Org Chem 22 1171 1857, Kharash et al. J Org Chem 10 392 1945, Blomquist & Winslow J Org Chem 10 156 1945, Beilstein 2 I 317, 2 III 1995, 2 IV 2295.]

ACETYLENEDICARBOXAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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ACETYLENEDICARBOXAMIDE Suppliers

Belgium 1 China 29 Germany 1 Japan 1 United Kingdom 3 United States 7 Global 42
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
Advantage
58
BOC Sciences
Tel
16314854226; +16314854226
Email
inquiry@bocsci.com
Country
United States
ProdList
19741
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
52925
Advantage
58
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6962
Advantage
56
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
Pfaltz & Bauer, Inc.
Tel
--
Fax
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Email
sales@pfaltzandbauer.com
Country
United States
ProdList
6828
Advantage
72

543-21-5, ACETYLENEDICARBOXAMIDERelated Search:

Diphenylacetylene Acetylenedicarboxylic acid PROPARGYLAMINE PROPYNOIC ACID AMIDE ACETYLENEDICARBOXAMIDE

  • Acetylendicarbonsaeureamid
  • Acetylenedicarboxylic acid diamide
  • acetylenedicarboxylicaciddiamide
  • Aquamycin
  • Lenamycin
  • Renamycin
  • 2-BUTYNEDIAMIDE
  • ACETYLENEDICARBOXAMIDE
  • ACETYLENEDICARBOXAMIDE (PRACT), 95%
  • 1,2-Ethynedicarboxamide
  • Acetylenedicarboxamide,95%,pract.
  • Acetylenedicarboxamide2-Butynediamide
  • but-2-ynediaMide
  • AquaMycin, ButynesiaMide, LenaMycin
  • 4-Dioxane-2
  • 543-21-5