Lorigerlimab

Product Name: Lorigerlimab
CAS No.: 2416595-46-3
Chemical Name: Lorigerlimab
Synonyms: Lorigerlimab;Research Grade Lorigerlimab;Research Grade Lorigerlimab (DHD17208)
CBNumber: CB710617086
Formula Weight: 0
MOL File: Mol file

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Hazard and Precautionary Statements (GHS)

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Lorigerlimab Chemical Properties,Usage,Production

Uses

Lorigerlimab (MGD019) is a bispecific IgG4 dual-affinity re-targeting antibody (DART). Lorigerlimab can block PD-1 and CTLA-4, and improves T-cell responses. Lorigerlimab can be used for research of metastatic castration-resistant prostate cancer (mCRPC)[1][2][3].

in vivo

Lorigerlimab (75 mg/kg, i.v.) shows CTLA-4 blockade in in cynomolgus monkeys^[2].
Lorigerlimab (10-100 mg/kg, i.v., 4 weeks) is well tolerated in cynomolgus monkeys, and shows a half-life about 7 days^[2].

Animal Model:	Cynomolgus monkeys ^[4]
Dosage:	75 mg/kg
Administration:	i.v.
Result:	Increased the Ki67+ T cell fraction, and showed T cell expansion in the spleen.

References

[1] Jason J. Luke, et al. Lorigerlimab, a bispecific PD-1×CTLA-4 DART molecule in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC): A phase 1 expansion (exp) cohort. Journal of Clinical Oncology 2023 41:6_suppl, 155-155.
[2] Berezhnoy A, et al. Development and Preliminary Clinical Activity of PD-1-Guided CTLA-4 Blocking Bispecific DART Molecule. Cell Rep Med. 2020 Dec 22;1(9):100163. DOI:10.1016/j.xcrm.2020.100163
[3] Trojaniello C, Luke JJ, Ascierto PA. Therapeutic Advancements Across Clinical Stages in Melanoma, With a Focus on Targeted Immunotherapy. Front Oncol. 2021 Jun 10;11:670726. DOI:10.3389/fonc.2021.670726

Lorigerlimab Preparation Products And Raw materials

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Preparation Products

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Lorigerlimab Suppliers

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Lorigerlimab

Research Grade Lorigerlimab (DHD17208)

Research Grade Lorigerlimab

2416595-46-3