Gancotamab

Product Name: Gancotamab
CAS No.: 1509928-00-0
Chemical Name: Gancotamab
Synonyms: Gancotamab;Gancotamab (anti-HER2);Research Grade Gancotamab;Research Grade Gancotamab (DHC09606)
CBNumber: CB78081116
Formula Weight: 0
MOL File: Mol file

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Hazard and Precautionary Statements (GHS)

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Gancotamab Chemical Properties,Usage,Production

Uses

Gancotamab (MM-302) is a HER2-targeted antibody-liposomal Doxorubicin conjugate with antitumor activity. Gancotamab encapsulates Doxorubicin to facilitate its delivery to HER2-overexpressing tumor cells[1].

in vivo

Gancotamab (MM-302; 3 mg/kg; i.v.; every 7 days; for 3 doses) shows tumor growth inhibition and increases the expression of the DNA damage marker p-p53^[1].

Animal Model:	Seven-week-old female NCR/nu mice injected with NCI-N87 cells^[1]
Dosage:	3 mg/kg
Administration:	i.v.; every 7 days; for 3 doses
Result:	Showed significantly antitumor activity.

IC 50

HER2

References

[1] Christopher W Espelin, et al. Dual HER2 Targeting with Trastuzumab and Liposomal-Encapsulated Doxorubicin (MM-302) Demonstrates Synergistic Antitumor Activity in Breast and Gastric Cancer. Cancer Res. 2016 Mar 15;76(6):1517-27. DOI:10.1158/0008-5472.CAN-15-1518

Gancotamab Preparation Products And Raw materials

Raw materials

Preparation Products

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Gancotamab Suppliers

China 15 Global 15

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1509928-00-0, GancotamabRelated Search:

Abrezekimab Immunoglobulin G1, anti-(human neuregulin receptor HER3) (human monoclonal U3-1287 heavy chain), disulfide with human monoclonal U3-1287 κ-chain, dimer Faricimab Ormutivimab Vilobelimab Berlimatoxumab Zenocutuzumab Flotetuzumab Obiltoxaximab Enoticumab

Gancotamab

Research Grade Gancotamab (DHC09606)

Research Grade Gancotamab

Gancotamab (anti-HER2)

1509928-00-0