Zenocutuzumab

Product Name: Zenocutuzumab
CAS No.: 1969309-56-5
Chemical Name: Zenocutuzumab
Synonyms: Zenocutuzumab;Research Grade Zenocutuzumab;Research Grade Zenocutuzumab (DHC09609)
CBNumber: CB98081059
Formula Weight: 0
MOL File: Mol file

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Zenocutuzumab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Zenocutuzumab Chemical Properties,Usage,Production

Uses

Zenocutuzumab (MCLA-128) is a bispecific humanized IgG1 antibody containing two different Fab arms, targeting extracellular domains of HER2 and HER3[1].

in vivo

Zenocutuzumab (2.5-25 mg/kg; i.p.; once weekly; for 28 days) causes a statistically significant reduction of growth, including tumor regression^[1].

Animal Model:	6 to 12-week-old female NSG? (LUAD-0061AS3), BALB/c nude (OV-10–0050) or athymic nude (ST2891, ST3204 and CTG-0953) mice injected with NRG1 fusion-positive patient-derived xenograft (PDX) tumors^[1].
Dosage:	2.5 mg/kg, 8 mg/kg, or 25 mg/kg
Administration:	i.p.; once weekly; for 28 days
Result:	Blocked growth of lung and ovarian cancer PDX models.

References

[1] Alison M Schram, et al. Zenocutuzumab, a HER2xHER3 Bispecific Antibody, Is Effective Therapy for Tumors Driven by NRG1 Gene Rearrangements. Cancer Discov. 2022 May 2;12(5):1233-1247. DOI:10.1158/2159-8290.CD-21-1119

Zenocutuzumab Preparation Products And Raw materials

Raw materials

Preparation Products

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Zenocutuzumab Suppliers

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Zenocutuzumab

Research Grade Zenocutuzumab (DHC09609)

Research Grade Zenocutuzumab

1969309-56-5