ChemicalBook > CAS DataBase List > Dehydrocostus lactone

Dehydrocostus lactone

Product Name: Dehydrocostus lactone
CAS No.: 477-43-0
Chemical Name: Dehydrocostus lactone
Synonyms: EPILIGULYL OXIDE;DEHYDROCOSTUNOLIDE;ehydrocostuslactone;DEHYDROCOSTUSLACTONE;dehydrocostiolactone;Costus lactone, dehydro-;Dehydrocostus lactone-RM;DEHYDROCOSTUS LACTONE hplc;Dehydrocostus lactone, >=98%;Dehydrocostuslactone Standard
CBNumber: CB7106297
Molecular Formula: C15H18O2
Formula Weight: 230.3
MOL File: 477-43-0.mol

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Dehydrocostus lactone Property

Melting point:: 57.0 to 61.0 °C
Boiling point:: 140-143 °C(Press: 0.5 Torr)
Density: 1.09
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
form: Solid
color: White to Off-White
Odor: nutty
optical activity: [α]/D -14.0±3.0°, c = 1 in chloroform
λmax: 206nm(MeOH)(lit.)
InChI: InChI=1S/C15H18O2/c1-8-4-7-12-10(3)15(16)17-14(12)13-9(2)5-6-11(8)13/h11-14H,1-7H2/t11-,12-,13-,14-/m0/s1
InChIKey: NETSQGRTUNRXEO-XUXIUFHCSA-N
SMILES: O1C(=O)C(=C)[C@]2([H])CCC(=C)[C@@]3([H])[C@@]([H])([C@@]12[H])C(=C)CC3
LogP: 1.480 (est)
CAS DataBase Reference: 477-43-0(CAS DataBase Reference)

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Safety

Safety Statements: 24/25
HS Code: 29322090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 42575
Product name: Dehydrocostus lactone
Purity: analytical standard
Packaging: 10mg
Price: $108
Updated: 2025/07/31

TCI Chemical

Product number: D5366
Product name: Dehydrocostus Lactone
Purity: >98.0%(GC)
Packaging: 10mg
Price: $73
Updated: 2025/07/31

TCI Chemical

Product number: D5366
Product name: Dehydrocostus Lactone
Purity: >98.0%(GC)
Packaging: 50mg
Price: $225
Updated: 2025/07/31

Cayman Chemical

Product number: 18485
Product name: Dehydrocostus lactone
Purity: ≥95%
Packaging: 5mg
Price: $54
Updated: 2024/03/01

Cayman Chemical

Product number: 18485
Product name: Dehydrocostus lactone
Purity: ≥95%
Packaging: 10mg
Price: $78
Updated: 2024/03/01

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Dehydrocostus lactone Chemical Properties,Usage,Production

Description

Dehydrocostus lactone is a natural sesquiterpene first isolated from costus root, which is used in traditional medicine. Dehydrocostus lactone has diverse anti-cancer properties in cells and animal models, causing cell cycle arrest, inducing apoptosis, diminishing multidrug resistance, and suppressing angiogenesis in cancer cells. It also has anti-inflammatory actions in cells, including the inhibition of signaling through STAT1 and STAT3.

Description

A guaianolide sesquiterpene lactone extracted from costus oil. Dehydrocostuslactone is one of the components of lactone-mix, with costunolide and alantolactone, used to detect Compositae-sensitive patients.

Chemical Properties

Soluble in ethyl acetate, acetone, DMSO and other solvents, insoluble in water. Derived from Chuanmuxiang [Vladimiria souliei(Franch.)Ling], family Asteraceae.

Uses

Dehydrocostus lactone is the oil extracted from Saussurea lappa is used in perfumery and in the Orient for all kinds of diseases.

Uses

Dehydrocostus Lactone is a compound known to be a growth regulator in plants. Known to affect cell viability and cell cycle distribution it may be useful in the application towards drug-resistant tumors.

Definition

ChEBI: An organic heterotricyclic compound and guaianolide sesquiterpene lactone that is acrylic acid which is substituted at position 2 by a 4-hydroxy-3,8-bis(methylene)decahydoazulen-5-yl group and in which the hydroxy group and the carboxy group have undergone formal condensation to afford the corresponding gamma-lactone.

Contact allergens

A guaianolide sesquiterpene lactone extracted from costus oil. It is one of the components of Lactone mix, with costunolide and alantolactone, used to detect Compositae-sensitive patients.

References

[1] MADAN MOHAN PANDEY Ajay K S R Subha Rastogi. Saussurea costus: Botanical, chemical and pharmacological review of an ayurvedic medicinal plant[J]. Journal of ethnopharmacology, 2007, 110 3: Pages 379-390. DOI: 10.1016/j.jep.2006.12.033
[2] CHIH-YA WANG. Dehydrocostuslactone suppresses angiogenesis in vitro and in vivo through inhibition of Akt/GSK-3β and mTOR signaling pathways.[J]. PLoS ONE, 2012: e31195. DOI: 10.1371/journal.pone.0031195
[3] BIRGIT LOHBERGER. Sesquiterpene lactones downregulate G2/M cell cycle regulator proteins and affect the invasive potential of human soft tissue sarcoma cells.[J]. PLoS ONE, 2013: e66300. DOI: 10.1371/journal.pone.0066300
[4] XUEJING LIN Changqing S Zhangxiao Peng. Potential anti-cancer activities and mechanisms of costunolide and dehydrocostuslactone.[J]. International Journal of Molecular Sciences, 2015, 16 5: 10888-10906. DOI: 10.3390/ijms160510888
[5] ELENA BUTTURINI. Two naturally occurring terpenes, dehydrocostuslactone and costunolide, decrease intracellular GSH content and inhibit STAT3 activation.[J]. PLoS ONE, 2011: e20174. DOI: 10.1371/journal.pone.0020174
[6] CLAUDIA SCARPONI. Inhibition of inflammatory and proliferative responses of human keratinocytes exposed to the sesquiterpene lactones dehydrocostuslactone and costunolide.[J]. ACS Applied Bio Materials, 2014: e107904. DOI: 10.1371/journal.pone.0107904

Dehydrocostus lactone Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Dehydrocostus lactone manufacturers

Hebei Chuanghai Biotechnology Co,.LTD

Product: Dehydrocostus Lactone 477-43-0
Price: US $11.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-08-21

Shaanxi Dideu Medichem Co. Ltd

Product: Dehydrocostus lactone 477-43-0
Price: US $30.00-20.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200000KG
Release date: 2024-08-06

Shaanxi Haibo Biotechnology Co., Ltd

Product: Dehydrocostus lactone 477-43-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 2000ton
Release date: 2023-08-21

477-43-0, Dehydrocostus lactoneRelated Search:

Tris(hydroxymethyl)aminomethane Methylene Blue 4,4'-Diphenylmethane diisocyanate Dehydrocostuslactone CYANIDIN CHLORIDE Tricine Furan D-(+)-Glucono-1,5-lactone Spironolactone Costunolide TRIOXSALEN Costuslactone Methylene Chloride Dehydrocostus lactone DEHYDROCOSTUSLACTONE(RG) Dehydrocostuslactone std. Dihydrodehydrocostus lactone

EPILIGULYL OXIDE

DEHYDROCOSTUSLACTONE

DEHYDROCOSTUS LACTONE hplc

(3aS,6aR,9aR,9bS)-Decahydro-3,6,9-tris(methylene)azuleno[4,5-b]furan-2(3H)-one

DEHYDROCOSTUNOLIDE

Azuleno[4,5-b]furan-2(3H)-one,decahydro-3,6,9-

Costus lactone, dehydro-

tris(methylene)-,(3aS,6aR,9aR,9bS)-

(3aS)-3,6,9-Tris(methylene)-2,3,3a,4,5,6,6aβ,7,8,9,9aβ,9bα-dodecahydroazuleno[4,5-b]furan-2-one

(3aS,6aβ,9aβ,9bα)-Dodecahydro-3,6,9-tris(methylene)azuleno[4,5-b]furan-2-one

3aβ,4,5,6,6aβ,7,8,9,9aβ,9bα-Decahydro-3,6,9-trismethyleneazuleno[4,5-b]furan-2(3H)-one

(3aS,6aR,9aR,9bS)-3,6,9-trimethylene-3a,4,5,6a,7,8,9a,9b-octahydroazuleno[4,5-b]furan-2-one

(3aS,6aR,9aR,9bS)-3,6,9-trimethylidene-3a,4,5,6a,7,8,9a,9b-octahydroazuleno[4,5-b]furan-2-one

Dehydrocostus Lactone 477-43-0

[3aS-(3aalpha,6aalpha,9aalpha,9bbeta)]-Decahydro-3,6,9-tris(methylene)-azuleno[4,5-b]furan-2(3H)-one

Dehydro-costus lactone (6CI,7CI)

Guaia-4(15),10(14),11(13)-trien-12-oic acid, 6alpha-hydroxy-, gamma-lactone

Dehydrocostus lactone, >=98%

Dehydrocostuslactone, 98%, from Common Vladimiria Root

Dehydrocostus Lactone ((-)-Dehydrocostus lactone

Dehydrocostuslactone Standard

Azuleno[4,5-b]furan-2(3H)-one, decahydro-3,6,9-tris(methylene)-, (3aS,6aR,9aR,9bS)-

ehydrocostuslactone

(3aS,6aR,9aR,9bS)-3,6,9-Trimethylenedecahydroazuleno[4,5-b]furan-2(9bH)-one

(3aS,6aR,9aR,9bS)-3,6,9-Trimethylenedecahydroazuleno[4,5-b]furan-2(3H)-one

dehydrocostiolactone

Dehydrocostus lactone-RM

Dehydrocostus lactone, Cell proliferation inhibitor

477-43-0

447-43-0

C15H18O2

Sesquiterpenoids

Inhibitors

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

Heterocycles